Detalhe da pesquisa
1.
Crystal structures of Schistosoma mansoni histone deacetylase 8 reveal a novel binding site for allosteric inhibitors.
J Biol Chem
; 298(10): 102375, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35970392
2.
Artificial intelligence-driven identification of morin analogues acting as CaV1.2 channel blockers: Synthesis and biological evaluation.
Bioorg Chem
; 131: 106326, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36563413
3.
Development of 1-(2-aminophenyl)pyrrole-based amides acting as human topoisomerase I inhibitors.
Arch Pharm (Weinheim)
; 356(10): e2300270, 2023 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-37452410
4.
Pioneering first-in-class FAAH-HDAC inhibitors as potential multitarget neuroprotective agents.
Arch Pharm (Weinheim)
; 356(12): e2300410, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37750286
5.
Development of Quinazolinone Derivatives as Modulators of Virulence Factors of Pseudomonas aeruginosa Cystic Fibrosis Strains.
Molecules
; 28(18)2023 Sep 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37764311
6.
Novel Labdane Diterpenes-Based Synthetic Derivatives: Identification of a Bifunctional Vasodilator That Inhibits CaV1.2 and Stimulates KCa1.1 Channels.
Mar Drugs
; 20(8)2022 Aug 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-36005518
7.
A Therapeutic Perspective of HDAC8 in Different Diseases: An Overview of Selective Inhibitors.
Int J Mol Sci
; 23(17)2022 Sep 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36077415
8.
Covalent Reversible Inhibitors of Cysteine Proteases Containing the Nitrile Warhead: Recent Advancement in the Field of Viral and Parasitic Diseases.
Molecules
; 27(8)2022 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35458759
9.
Total Synthesis of the Natural Chalcone Lophirone E, Synthetic Studies toward Benzofuran and Indole-Based Analogues, and Investigation of Anti-Leishmanial Activity.
Molecules
; 27(2)2022 Jan 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35056779
10.
A novel class of oxazepine-based anti-cancer agents induces cell death in primary human CLL cells and efficiently reduces tumor growth in Eµ-TCL1 mice through the JNK/STAT4/p66Shc axis.
Pharmacol Res
; 174: 105965, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34732370
11.
Autophagy modulators for the treatment of oral and esophageal squamous cell carcinomas.
Med Res Rev
; 40(3): 1002-1060, 2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31742748
12.
(+)-(R)- and (-)-(S)-Perhexiline maleate: Enantioselective synthesis and functional studies on Schistosoma mansoni larval and adult stages.
Bioorg Chem
; 102: 104067, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32663671
13.
Computer-Driven Development of an in Silico Tool for Finding Selective Histone Deacetylase 1 Inhibitors.
Molecules
; 25(8)2020 Apr 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-32331470
14.
Cinnamides Target Leishmania amazonensis Arginase Selectively.
Molecules
; 25(22)2020 Nov 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33198198
15.
Bridged bicyclic 2,3-dioxabicyclo[3.3.1]nonanes as antiplasmodial agents: Synthesis, structure-activity relationships and studies on their biomimetic reaction with Fe(II).
Bioorg Chem
; 89: 103020, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31185392
16.
iPSC-derived neurons profiling reveals GABAergic circuit disruption and acetylated α-tubulin defect which improves after iHDAC6 treatment in Rett syndrome.
Exp Cell Res
; 368(2): 225-235, 2018 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29730163
17.
A Repurposing Approach for Uncovering the Anti-Tubercular Activity of FDA-Approved Drugs with Potential Multi-Targeting Profiles.
Molecules
; 24(23)2019 Nov 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-31795400
18.
Involvement of AMP-activated protein kinase in mediating pyrrolo-1,5-benzoxazepine-induced apoptosis in neuroblastoma cells.
Invest New Drugs
; 34(5): 663-76, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27334143
19.
The novel pyrrolo-1,5-benzoxazepine, PBOX-15, synergistically enhances the apoptotic efficacy of imatinib in gastrointestinal stromal tumours; suggested mechanism of action of PBOX-15.
Invest New Drugs
; 34(2): 159-67, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26885657
20.
Verbascoside Inhibits Promastigote Growth and Arginase Activity of Leishmania amazonensis.
J Nat Prod
; 79(5): 1459-63, 2016 05 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-27096224