Detalhe da pesquisa
1.
Perturbations in actin dynamics reconfigure protein complexes that modulate GCN2 activity and promote an eIF2 response.
J Cell Sci
; 129(24): 4521-4533, 2016 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27852836
2.
A membrane-bound eIF2 alpha kinase located in endosomes is regulated by heme and controls differentiation and ROS levels in Trypanosoma cruzi.
PLoS Pathog
; 11(2): e1004618, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25658109
3.
IMPACT is a GCN2 inhibitor that limits lifespan in Caenorhabditis elegans.
BMC Biol
; 14(1): 87, 2016 10 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27717342
4.
Keeping the eIF2 alpha kinase Gcn2 in check.
Biochim Biophys Acta
; 1843(9): 1948-68, 2014 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-24732012
5.
IMPACT is a developmentally regulated protein in neurons that opposes the eukaryotic initiation factor 2α kinase GCN2 in the modulation of neurite outgrowth.
J Biol Chem
; 288(15): 10860-9, 2013 Apr 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-23447528
6.
Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2.
Biochem Biophys Res Commun
; 443(2): 592-7, 2014 Jan 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-24333428
7.
GCN2 kinase plays an important role triggering the remission phase of experimental autoimmune encephalomyelitis (EAE) in mice.
Brain Behav Immun
; 37: 177-86, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24362236
8.
Eukaryotic initiation factor 5A dephosphorylation is required for translational arrest in stationary phase cells.
Biochem J
; 451(2): 257-67, 2013 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23368777
9.
The NIP7 protein is required for accurate pre-rRNA processing in human cells.
Nucleic Acids Res
; 39(2): 648-65, 2011 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-20798176
10.
Prion protein interaction with stress-inducible protein 1 enhances neuronal protein synthesis via mTOR.
Proc Natl Acad Sci U S A
; 107(29): 13147-52, 2010 Jul 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-20615969
11.
Gcn1 and actin binding to Yih1: implications for activation of the eIF2 kinase GCN2.
J Biol Chem
; 286(12): 10341-55, 2011 Mar 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-21239490
12.
Evidence that eukaryotic translation elongation factor 1A (eEF1A) binds the Gcn2 protein C terminus and inhibits Gcn2 activity.
J Biol Chem
; 286(42): 36568-79, 2011 Oct 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-21849502
13.
Yeast as a Model to Understand Actin-Mediated Cellular Functions in Mammals-Illustrated with Four Actin Cytoskeleton Proteins.
Cells
; 9(3)2020 03 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32164332
14.
Multiple RNAs from the mouse carboxypeptidase M locus: functional RNAs or transcription noise?
BMC Mol Biol
; 10: 7, 2009 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-19200403
15.
GCN2 activation and eIF2alpha phosphorylation in the maturation of mouse oocytes.
Biochem Biophys Res Commun
; 378(1): 41-4, 2009 Jan 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-18996085
16.
The GCN2 inhibitor IMPACT contributes to diet-induced obesity and body temperature control.
PLoS One
; 14(6): e0217287, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31166980
17.
Dietary sulfur amino acid restriction upregulates DICER to confer beneficial effects.
Mol Metab
; 29: 124-135, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31668384
18.
A Rapid Extraction Method for mammalian cell cultures, suitable for quantitative immunoblotting analysis of proteins, including phosphorylated GCN2 and eIF2α.
MethodsX
; 5: 75-82, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30619721
19.
Topical Dexamethasone Administration Impairs Protein Synthesis and Neuronal Regeneration in the Olfactory Epithelium.
Front Mol Neurosci
; 11: 50, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29559887
20.
Phosphorylation of the alpha subunit of translation initiation factor-2 by PKR mediates protein synthesis inhibition in the mouse brain during status epilepticus.
Biochem J
; 397(1): 187-94, 2006 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16492139