Detalhe da pesquisa
1.
A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization.
Nat Chem Biol
; 18(1): 56-63, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34782742
2.
Kinetic characterization of human histone H3 lysine 36 methyltransferases, ASH1L and SETD2.
Biochim Biophys Acta
; 1850(9): 1842-8, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-26002201
3.
Trimethylation of histone H3 lysine 36 by human methyltransferase PRDM9 protein.
J Biol Chem
; 289(17): 12177-12188, 2014 Apr 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-24634223
4.
Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5.
Biochem J
; 449(1): 151-9, 2013 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22989411
5.
Discovery of a Potent, Selective, and Cell-Active SPIN1 Inhibitor.
J Med Chem
; 67(7): 5837-5853, 2024 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38533580
6.
Drug Discovery in Low Data Regimes: Leveraging a Computational Pipeline for the Discovery of Novel SARS-CoV-2 Nsp14-MTase Inhibitors.
bioRxiv
; 2024 Jan 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-37873443
7.
A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells.
Nat Chem Biol
; 7(8): 566-74, 2011 Jul 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-21743462
8.
SS148 and WZ16 inhibit the activities of nsp10-nsp16 complexes from all seven human pathogenic coronaviruses.
Biochim Biophys Acta Gen Subj
; 1867(4): 130319, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36764586
9.
Development of selective class I protein arginine methyltransferase inhibitors through fragment-based drug design approach.
Eur J Med Chem
; 260: 115713, 2023 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37597437
10.
The co-crystal structure of Cbl-b and a small-molecule inhibitor reveals the mechanism of Cbl-b inhibition.
Commun Biol
; 6(1): 1272, 2023 12 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38104184
11.
Structure-Based Discovery of Inhibitors of the SARS-CoV-2 Nsp14 N7-Methyltransferase.
J Med Chem
; 66(12): 7785-7803, 2023 06 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-37294077
12.
Crystal structure of SARS-CoV-2 nsp10-nsp16 in complex with small molecule inhibitors, SS148 and WZ16.
Protein Sci
; 31(9): e4395, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36040262
13.
Enzymatic nucleosome acetylation selectively affects activity of histone methyltransferases in vitro.
Biochim Biophys Acta Gene Regul Mech
; 1865(5): 194845, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35907431
14.
The Cryptosporidium parvum kinome.
BMC Genomics
; 12: 478, 2011 Sep 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-21962082
15.
The Structure-Based Design of SARS-CoV-2 nsp14 Methyltransferase Ligands Yields Nanomolar Inhibitors.
ACS Infect Dis
; 7(8): 2214-2220, 2021 08 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-34152728
16.
Development of LM98, a Small-Molecule TEAD Inhibitor Derived from Flufenamic Acid.
ChemMedChem
; 16(19): 2982-3002, 2021 10 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34164919
17.
Probing the SAM Binding Site of SARS-CoV-2 Nsp14 In Vitro Using SAM Competitive Inhibitors Guides Developing Selective Bisubstrate Inhibitors.
SLAS Discov
; 26(9): 1200-1211, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34192965
18.
Probing the SAM Binding Site of SARS-CoV-2 nsp14 in vitro Using SAM Competitive Inhibitors Guides Developing Selective bi-substrate Inhibitors.
bioRxiv
; 2021 Feb 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-33619486
19.
Discovery of the SMYD3 Inhibitor BAY-6035 Using Thermal Shift Assay (TSA)-Based High-Throughput Screening.
SLAS Discov
; 26(8): 947-960, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34154424
20.
A First-in-Class, Highly Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 6.
J Med Chem
; 64(7): 3697-3706, 2021 04 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33591753