Detalhe da pesquisa
1.
Predictive models for estimating cytotoxicity on the basis of chemical structures.
Bioorg Med Chem
; 28(10): 115422, 2020 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32234277
2.
High-throughput screening with nucleosome substrate identifies small-molecule inhibitors of the human histone lysine methyltransferase NSD2.
J Biol Chem
; 293(35): 13750-13765, 2018 08 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-29945974
3.
Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors.
Bioorg Med Chem
; 26(8): 1727-1739, 2018 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29555419
4.
Development of an assay pipeline for the discovery of novel small molecule inhibitors of human glutathione peroxidases GPX1 and GPX4.
Redox Biol
; 63: 102719, 2023 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37244126
5.
The ferroptosis inducing compounds RSL3 and ML162 are not direct inhibitors of GPX4 but of TXNRD1.
Redox Biol
; 62: 102703, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37087975
6.
Arsenic exposure and increased C-reactive protein are independently associated with lower erythrocyte glutathione peroxidase activity in Bangladeshi children.
Redox Biochem Chem
; 5-62023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37908807
7.
Development of therapies for rare genetic disorders of GPX4: roadmap and opportunities.
Orphanet J Rare Dis
; 16(1): 446, 2021 10 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-34688299
8.
Discovery and Optimization of 2H-1λ2-Pyridin-2-one Inhibitors of Mutant Isocitrate Dehydrogenase 1 for the Treatment of Cancer.
J Med Chem
; 64(8): 4913-4946, 2021 04 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33822623
9.
Keeping It Clean: The Cell Culture Quality Control Experience at the National Center for Advancing Translational Sciences.
SLAS Discov
; 25(5): 491-497, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32233736
10.
Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
SLAS Discov
; 25(1): 9-20, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31498718
11.
Pyrazole-Based Lactate Dehydrogenase Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties.
J Med Chem
; 63(19): 10984-11011, 2020 10 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32902275
12.
Resistance to Epigenetic-Targeted Therapy Engenders Tumor Cell Vulnerabilities Associated with Enhancer Remodeling.
Cancer Cell
; 34(6): 922-938.e7, 2018 12 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30537514
13.
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
ACS Cent Sci
; 4(12): 1727-1741, 2018 Dec 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-30648156
14.
A Drug of Such Damned Nature.1 Challenges and Opportunities in Translational Platinum Drug Research.
J Med Chem
; 60(11): 4517-4532, 2017 06 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28195724
15.
Assessing inhibitors of mutant isocitrate dehydrogenase using a suite of pre-clinical discovery assays.
Sci Rep
; 7(1): 12758, 2017 10 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28986582
16.
Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH).
J Med Chem
; 60(22): 9184-9204, 2017 11 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-29120638
17.
Correction to A Drug of Such Damned Nature. Challenges and Opportunities in Translational Platinum Drug Research.
J Med Chem
; 61(19): 8944, 2018 Oct 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30260639