Detalhe da pesquisa
1.
Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases.
Nature
; 535(7610): 148-52, 2016 07 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27362227
2.
[Application of CRISPR/Cas9 mediated gene editing in trees].
Yi Chuan
; 42(7): 657-668, 2020 Jul 20.
Artigo
em Zh
| MEDLINE | ID: mdl-32694105
3.
The effect of banana (Musa acuminata) peels hot-water extract on the immunity and resistance of giant freshwater prawn, Macrobrachium rosenbergii via dietary administration for a long term: Activity and gene transcription.
Fish Shellfish Immunol
; 46(2): 378-86, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-26118934
4.
Synthesis, characterization and luminescent properties of europium complexes with 2,4,6-tris-(2-pyridyl)-s-triazine as highly efficient sensitizers.
Luminescence
; 30(8): 1360-6, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-25829339
5.
A green synthesized medicine residue carbon-based iron composite for the removal of chromium (VI) and cadmium (II): Performance, kinetics and mechanism.
Environ Sci Pollut Res Int
; 30(35): 84011-84022, 2023 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-37355513
6.
Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex.
Cancer Cell
; 5(1): 91-102, 2004 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-14749129
7.
Validating cancer drug targets.
Nature
; 441(7092): 451-6, 2006 May 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-16724057
8.
Identifying clinical risk factors correlate with suicide attempts in patients with first episode major depressive disorder.
J Affect Disord
; 295: 264-270, 2021 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34482058
9.
Assessing IRAK4 Functions in ABC DLBCL by IRAK4 Kinase Inhibition and Protein Degradation.
Cell Chem Biol
; 27(12): 1500-1509.e13, 2020 12 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-32888499
10.
Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of Cancer.
J Med Chem
; 63(22): 13578-13594, 2020 11 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-32910655
11.
Immune response of white shrimp, Litopenaeus vannamei, after a concurrent infection with white spot syndrome virus and infectious hypodermal and hematopoietic necrosis virus.
Fish Shellfish Immunol
; 26(4): 582-8, 2009 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-18948207
12.
Pollen Typhae Total Flavone Inhibits Endoplasmic Reticulum Stress-Induced Apoptosis in Human Aortic-Vascular Smooth Muscle Cells through Down-Regulating PERK-eIF2α-ATF4-CHOP Pathway.
Chin J Integr Med
; 25(8): 604-612, 2019 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-30707413
13.
6-Amino-3-methylpyrimidinones as Potent, Selective, and Orally Efficacious SHP2 Inhibitors.
J Med Chem
; 62(4): 1793-1802, 2019 02 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-30688459
14.
Optimization of Fused Bicyclic Allosteric SHP2 Inhibitors.
J Med Chem
; 62(4): 1781-1792, 2019 02 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-30688462
15.
Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor.
J Med Chem
; 59(17): 7773-82, 2016 09 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27347692
16.
Further studies on the interaction of nonpolyglutamatable aminopterin analogs with dihydrofolate reductase and the reduced folate carrier as determinants of in vitro antitumor activity.
Biochem Pharmacol
; 65(9): 1427-33, 2003 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-12732354
17.
Correction to Optimization of Fused Bicyclic Allosteric SHP2 Inhibitors.
J Med Chem
; 62(7): 3780, 2019 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30900881
18.
Correction to 6-Amino-3-methylpyrimidinones as Potent, Selective, and Orally Efficacious SHP2 Inhibitors.
J Med Chem
; 62(7): 3781, 2019 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30900883
19.
Synthesis of A83586C analogs with potent anticancer and beta-catenin/ TCF4/osteopontin inhibitory effects and insights into how A83586C modulates E2Fs and pRb.
Org Lett
; 11(3): 737-40, 2009 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-19175352
20.
[Antineutrophil cytoplasmic autoantibody positive vasculitis induced by propylthiouracil: a case report].
Zhonghua Er Ke Za Zhi
; 42(5): 379-82, 2004 May.
Artigo
em Zh
| MEDLINE | ID: mdl-15189700