Detalhe da pesquisa
1.
Trastuzumab-Induced Negative Chronotropic and Lusitropic Effects in Cynomolgus Monkeys.
J Cardiovasc Pharmacol
; 79(1): e41-e49, 2022 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34654786
2.
DS-8500a, an Orally Available G Protein-Coupled Receptor 119 Agonist, Upregulates Glucagon-Like Peptide-1 and Enhances Glucose-Dependent Insulin Secretion and Improves Glucose Homeostasis in Type 2 Diabetic Rats.
J Pharmacol Exp Ther
; 367(3): 509-517, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30217957
3.
Inotropic Effects of Nicorandil on Cardiac Contractility Assessed by Left Ventricular Pressure-Volume Relationship Analyses in Anesthetized Monkeys.
J Cardiovasc Pharmacol
; 71(2): 76-81, 2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29420355
4.
Enhanced Immunostimulating Activity of Lactobacilli-Mimicking Materials by Controlling Size.
Bioconjug Chem
; 26(8): 1775-81, 2015 Aug 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-26203868
5.
Synthesis and immunestimulating activity of lactobacilli-originated polysaccharide-polymeric microparticle conjugates.
Langmuir
; 31(4): 1489-95, 2015 Feb 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-25574583
6.
Synthesis and optimization of novel (3S,5R)-5-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)piperidine-3-carboxamides as orally active renin inhibitors.
Bioorg Med Chem
; 21(18): 5907-22, 2013 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23886807
7.
Lead optimization of 5-amino-6-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)-4-hydroxyhexanamides to reduce a cardiac safety issue: discovery of DS-8108b, an orally active renin inhibitor.
Bioorg Med Chem
; 21(11): 3175-96, 2013 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23598247
8.
Photoprotective effects of Bifidobacterium breve supplementation against skin damage induced by ultraviolet irradiation in hairless mice.
Photodermatol Photoimmunol Photomed
; 28(6): 312-9, 2012 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-23126293
9.
[In vivo integrated safety assessment of the cardiovascular system in drug development].
Nihon Yakurigaku Zasshi
; 157(1): 47-52, 2022.
Artigo
em Japonês
| MEDLINE | ID: mdl-34980813
10.
Time for a Fully Integrated Nonclinical-Clinical Risk Assessment to Streamline QT Prolongation Liability Determinations: A Pharma Industry Perspective.
Clin Pharmacol Ther
; 109(2): 310-318, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32866317
11.
Ultrasonographic measurement of the renal resistive index in the cynomolgus monkey (Macaca fascicularis) under conscious and ketamine-immobilized conditions.
Exp Anim
; 69(1): 119-126, 2020 Jan 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-31645524
12.
Comprehensive analysis of cardiac function, blood biomarkers and histopathology for milrinone-induced cardiotoxicity in cynomolgus monkeys.
J Pharmacol Toxicol Methods
; 103: 106870, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32353509
13.
Negative lusitropic property of nifekalant identified using ventricular pressure-volume loop analyses in anesthetized monkeys.
Exp Anim
; 68(1): 91-102, 2019 Feb 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-30333366
14.
Exposure-response analysis of drug-induced QT interval prolongation in telemetered monkeys for translational prediction to human.
J Pharmacol Toxicol Methods
; 99: 106606, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31255745
15.
Usefulness of simultaneous and sequential monitoring of glucose level and electrocardiogram in monkeys treated with gatifloxacin under conscious and nonrestricted conditions.
Exp Anim
; 67(2): 281-290, 2018 May 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29311442
16.
Promising approach for the preclinical assessment of cardiac risks using left ventricular pressure-volume loop analyses in anesthetized monkeys.
J Pharmacol Toxicol Methods
; 84: 1-10, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-27756610
17.
A novel approach for the detection of proteolytically activated transglutaminase 1 in epidermis using cleavage site-directed antibodies.
J Invest Dermatol
; 121(3): 457-64, 2003 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-12925200
18.
Comparison of sensitivity of surrogate markers of drug-induced torsades de pointes in canine hearts.
Eur J Pharmacol
; 502(1-2): 117-22, 2004 Oct 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-15464097
19.
In vivo experimental approach for the risk assessment of fluoroquinolone antibacterial agents-induced long QT syndrome.
Eur J Pharmacol
; 486(2): 189-200, 2004 Feb 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-14975708
20.
Topical application of Bifidobacterium-fermented soy milk extract containing genistein and daidzein improves rheological and physiological properties of skin.
J Cosmet Sci
; 55(5): 473-9, 2004.
Artigo
em Inglês
| MEDLINE | ID: mdl-15608997