Detalhe da pesquisa
1.
Caspase-8-driven apoptotic and pyroptotic crosstalk causes cell death and IL-1ß release in X-linked inhibitor of apoptosis (XIAP) deficiency.
EMBO J
; 42(5): e110468, 2023 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36647737
2.
A key mammalian cholesterol synthesis enzyme, squalene monooxygenase, is allosterically stabilized by its substrate.
Proc Natl Acad Sci U S A
; 117(13): 7150-7158, 2020 03 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-32170014
3.
Reduction of Squalene Epoxidase by Cholesterol Accumulation Accelerates Colorectal Cancer Progression and Metastasis.
Gastroenterology
; 160(4): 1194-1207.e28, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-32946903
4.
The Degron Architecture of Squalene Monooxygenase and How Specific Lipids Calibrate Levels of This Key Cholesterol Synthesis Enzyme.
Adv Exp Med Biol
; 21: 1-12, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-32979157
5.
Non-canonical ubiquitination of the cholesterol-regulated degron of squalene monooxygenase.
J Biol Chem
; 294(20): 8134-8147, 2019 05 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-30940729
6.
Valosin-containing protein mediates the ERAD of squalene monooxygenase and its cholesterol-responsive degron.
Biochem J
; 476(18): 2545-2560, 2019 09 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-31471528
7.
Mallostery: Filling a niche between quality and metabolic control.
J Biol Chem
; 293(38): 14951-14952, 2018 09 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-30242042
8.
A conserved degron containing an amphipathic helix regulates the cholesterol-mediated turnover of human squalene monooxygenase, a rate-limiting enzyme in cholesterol synthesis.
J Biol Chem
; 292(49): 19959-19973, 2017 12 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28972164
9.
The Regulatory Domain of Squalene Monooxygenase Contains a Re-entrant Loop and Senses Cholesterol via a Conformational Change.
J Biol Chem
; 290(46): 27533-44, 2015 Nov 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-26434806
10.
Lipid sensing tips the balance for a key cholesterol synthesis enzyme.
J Lipid Res
; 61(11): 1363, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32371565
11.
Correction: Mallostery: Filling a niche between quality and metabolic control.
J Biol Chem
; 293(42): 16176, 2018 10 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-30341216
12.
Development of NanoLuc-targeting protein degraders and a universal reporter system to benchmark tag-targeted degradation platforms.
Nat Commun
; 13(1): 2073, 2022 04 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35440107
13.
Epithelial-to-Mesenchymal Transition Supports Ovarian Carcinosarcoma Tumorigenesis and Confers Sensitivity to Microtubule Targeting with Eribulin.
Cancer Res
; 82(23): 4457-4473, 2022 12 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36206301
14.
Squalene monooxygenase: a journey to the heart of cholesterol synthesis.
Prog Lipid Res
; 79: 101033, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32360125
15.
Consulting prostate cancer cohort data uncovers transcriptional control: Regulation of the MARCH6 gene.
Biochim Biophys Acta Mol Cell Biol Lipids
; 1864(11): 1656-1668, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31422115
16.
The shape of human squalene epoxidase expands the arsenal against cancer.
Nat Commun
; 10(1): 888, 2019 02 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-30792392
17.
Cholesterol, cancer, and rebooting a treatment for athlete's foot.
Sci Transl Med
; 10(437)2018 04 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-29669852
18.
Cholesterol homeostasis: How do cells sense sterol excess?
Chem Phys Lipids
; 199: 170-178, 2016 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-26993747