Detalhe da pesquisa
1.
Live-cell fluorescence imaging of microgametogenesis in the human malaria parasite Plasmodium falciparum.
PLoS Pathog
; 18(2): e1010276, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35130301
2.
Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome.
Proc Natl Acad Sci U S A
; 118(39)2021 09 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-34548400
3.
Potent Plasmodium falciparum gametocytocidal compounds identified by exploring the kinase inhibitor chemical space for dual active antimalarials.
J Antimicrob Chemother
; 73(5): 1279-1290, 2018 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29420756
4.
Fast-Killing Tyrosine Amide ((S)-SW228703) with Blood- and Liver-Stage Antimalarial Activity Associated with the Cyclic Amine Resistance Locus (PfCARL).
ACS Infect Dis
; 9(3): 527-539, 2023 03 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36763526
5.
7-N-Substituted-3-oxadiazole Quinolones with Potent Antimalarial Activity Target the Cytochrome bc1 Complex.
ACS Infect Dis
; 9(3): 668-691, 2023 03 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36853190
6.
Optimization of 2,3-Dihydroquinazolinone-3-carboxamides as Antimalarials Targeting PfATP4.
J Med Chem
; 66(5): 3540-3565, 2023 03 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36812492
7.
Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy.
Science
; 376(6597): 1074-1079, 2022 06 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35653481
8.
Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183.
Nat Commun
; 13(1): 2158, 2022 04 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-35444200
9.
Novel Antimalarial Tetrazoles and Amides Active against the Hemoglobin Degradation Pathway in Plasmodium falciparum.
J Med Chem
; 64(5): 2739-2761, 2021 03 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33620219
10.
Repositioning and Characterization of 1-(Pyridin-4-yl)pyrrolidin-2-one Derivatives as Plasmodium Cytoplasmic Prolyl-tRNA Synthetase Inhibitors.
ACS Infect Dis
; 7(6): 1680-1689, 2021 06 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33929818
11.
Synthesis and Structure-Activity Relationship of Dual-Stage Antimalarial Pyrazolo[3,4-b]pyridines.
J Med Chem
; 63(20): 11902-11919, 2020 10 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-32945666
12.
Structure-Activity Relationship Studies and Plasmodium Life Cycle Profiling Identifies Pan-Active N-Aryl-3-trifluoromethyl Pyrido[1,2- a]benzimidazoles Which Are Efficacious in an in Vivo Mouse Model of Malaria.
J Med Chem
; 62(2): 1022-1035, 2019 01 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-30562027
13.
Antimalarial Pyrido[1,2-a]benzimidazoles: Lead Optimization, Parasite Life Cycle Stage Profile, Mechanistic Evaluation, Killing Kinetics, and in Vivo Oral Efficacy in a Mouse Model.
J Med Chem
; 60(4): 1432-1448, 2017 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-28094524
14.
A Novel Pyrazolopyridine with in Vivo Activity in Plasmodium berghei- and Plasmodium falciparum-Infected Mouse Models from Structure-Activity Relationship Studies around the Core of Recently Identified Antimalarial Imidazopyridazines.
J Med Chem
; 58(21): 8713-22, 2015 Nov 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-26502160