Detalhe da pesquisa
1.
Lower Affinity of Isradipine for L-Type Ca2+ Channels during Substantia Nigra Dopamine Neuron-Like Activity: Implications for Neuroprotection in Parkinson's Disease.
J Neurosci
; 37(28): 6761-6777, 2017 07 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-28592699
2.
AAV-mediated expression of a new conformational anti-aggregated α-synuclein antibody prolongs survival in a genetic model of α-synucleinopathies.
NPJ Parkinsons Dis
; 9(1): 91, 2023 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37322068
3.
Autoproteolytic fragments are intermediates in the oligomerization/aggregation of the Parkinson's disease protein alpha-synuclein as revealed by ion mobility mass spectrometry.
Chembiochem
; 12(18): 2740-4, 2011 Dec 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-22162214
4.
AAV-Mediated Expression of Human VEGF, TNF-α, and IL-6 Induces Retinal Pathology in Mice.
Transl Vis Sci Technol
; 10(11): 15, 2021 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34520511
5.
Formation of Lipofuscin-Like Autofluorescent Granules in the Retinal Pigment Epithelium Requires Lysosome Dysfunction.
Invest Ophthalmol Vis Sci
; 62(9): 39, 2021 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34313720
6.
A Small-Molecule-Responsive Riboswitch Enables Conditional Induction of Viral Vector-Mediated Gene Expression in Mice.
ACS Synth Biol
; 9(6): 1292-1305, 2020 06 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-32427483
7.
Opposing gradients of ephrin-As and EphA7 in the superior colliculus are essential for topographic mapping in the mammalian visual system.
Neuron
; 47(1): 57-69, 2005 Jul 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-15996548
8.
Area specificity and topography of thalamocortical projections are controlled by ephrin/Eph genes.
Neuron
; 39(3): 453-65, 2003 Jul 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-12895420
9.
Increased Oxidative Stress Exacerbates α-Synuclein Aggregation In Vivo.
J Neuropathol Exp Neurol
; 77(6): 443-453, 2018 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29718367
10.
Age-related pathology after adenoviral overexpression of the leucine-rich repeat kinase 2 in the mouse striatum.
Neurobiol Aging
; 66: 97-111, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29550548
11.
2-aroylindoles and 2-aroylbenzofurans with N-hydroxyacrylamide substructures as a novel series of rationally designed histone deacetylase inhibitors.
J Med Chem
; 50(18): 4405-18, 2007 Sep 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-17691763
12.
Identification and affinity-quantification of ß-amyloid and α-synuclein polypeptides using on-line SAW-biosensor-mass spectrometry.
J Am Soc Mass Spectrom
; 25(8): 1472-81, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24845351
13.
Novel chimeric histone deacetylase inhibitors: a series of lapatinib hybrides as potent inhibitors of epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), and histone deacetylase activity.
J Med Chem
; 53(24): 8546-55, 2010 Dec 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-21080629
14.
Design of chimeric histone deacetylase- and tyrosine kinase-inhibitors: a series of imatinib hybrides as potent inhibitors of wild-type and mutant BCR-ABL, PDGF-Rbeta, and histone deacetylases.
J Med Chem
; 52(8): 2265-79, 2009 Apr 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-19301902
15.
A homogeneous cellular histone deacetylase assay suitable for compound profiling and robotic screening.
Anal Biochem
; 372(1): 72-81, 2008 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17868634
16.
Trithiocarbonates as a novel class of HDAC inhibitors: SAR studies, isoenzyme selectivity, and pharmacological profiles.
J Med Chem
; 51(13): 3985-4001, 2008 Jul 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-18558669
17.
Trithiocarbonates: exploration of a new head group for HDAC inhibitors.
Bioorg Med Chem Lett
; 17(17): 4746-52, 2007 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17606370
18.
Distinct pharmacological properties of second generation HDAC inhibitors with the benzamide or hydroxamate head group.
Int J Cancer
; 121(5): 1138-48, 2007 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17455259
19.
Control of triglyceride storage by a WD40/TPR-domain protein.
EMBO Rep
; 4(5): 511-6, 2003 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-12717455