Comparative Analysis of Psychophysiological Responses in Fibromyalgia Patients: Evaluating Neuromodulation Alone, Neuromodulation Combined with Virtual Reality, and Exercise Interventions.

BACKGROUND AND OBJECTIVES: Fibromyalgia, a chronic condition, manifests as widespread musculoskeletal pain, fatigue, sleep disturbances, autonomic and cognitive dysfunction, hypersensitivity to stimuli, and various somatic and psychiatric symptoms. This study, a controlled and randomized experiment, aimed to evaluate and compare the immediate effects of different treatments on fibromyalgia patients. MATERIALS AND METHODS: The treatments included the EXOPULSE Mollii suit, a combination of the EXOPULSE Mollii suit with a virtual reality (VR) protocol, and a physical exercise regimen. A cohort of 89 female fibromyalgia patients was randomly assigned to one of four groups: Control (n = 20), Suit only (n = 22), Suit combined with VR (n = 21), and Exercise (n = 26). RESULTS: This study found notable differences across the groups in several key parameters. In the Control group, significant changes were observed in Forced Expiratory Volume (FEV 1/FEV 6), the Numeric Rating Scale (NRS) for pain, Pressure Pain Threshold (PPT) at the epicondyle, cortical arousal levels, the 10 m up-and-go test, and in all measured variables related to temperature and muscle oxygenation. For the group using the suit alone, there were significant differences noted in the NRS, the chair stand test, palm temperature, and all muscle oxygenation parameters. The Suit + VR group showed significant changes in the NRS, PPT at the knee, handgrip strength test, the 10 m up-and-go test, one-leg balance test with the right leg, muscle oxygen saturation (SmO2), deoxygenated hemoglobin (HHb), and oxygenated hemoglobin (O2Hb). Finally, the Exercise group exhibited significant differences in FEV 1/FEV 6, chest perimeter difference, NRS, PPT at both the epicondyle and knee, cortical arousal, the chair stand test, the 10-m up-and-go test, and in SmO2, HHb, and O2Hb levels. CONCLUSIONS: combining neuromodulation with VR and targeted exercise regimens can effectively alleviate fibromyalgia symptoms, offering promising avenues for non-pharmacological management.

Mitochondrial Transfer as a Novel Therapeutic Approach in Disease Diagnosis and Treatment.

Mitochondrial dysfunction is a hallmark of numerous diseases, including neurodegenerative disorders, metabolic disorders, and cancer. Mitochondrial transfer, the transfer of mitochondria from one cell to another, has recently emerged as a potential therapeutic approach for restoring mitochondrial function in diseased cells. In this review, we summarize the current understanding of mitochondrial transfer, including its mechanisms, potential therapeutic applications, and impact on cell death pathways. We also discuss the future directions and challenges in the field of mitochondrial transfer as a novel therapeutic approach in disease diagnosis and treatment.

New Insights and Potential Therapeutic Interventions in Metabolic Diseases.

Endocrine homeostasis and metabolic diseases have been the subject of extensive research in recent years. The development of new techniques and insights has led to a deeper understanding of the mechanisms underlying these conditions and opened up new avenues for diagnosis and treatment. In this review, we discussed the rise of metabolic diseases, especially in Western countries, the genetical, psychological, and behavioral basis of metabolic diseases, the role of nutrition and physical activity in the development of metabolic diseases, the role of single-cell transcriptomics, gut microbiota, epigenetics, advanced imaging techniques, and cell-based therapies in metabolic diseases. Finally, practical applications derived from this information are made.

Psychophysiological and Psychosocial Profile of Patients Attending Drug Addiction Centers.

Drug treatment centres provide the highest level of rehab services for patients diagnosed with drug addictions. Most inpatient drug rehab programs focus on medical detox and mental health interventions. However, how to optimize the later remains a challenge. The aim of this study was to examine the psychophysiological and psychosocial profile of patients attending drug addiction centres in comparation with the general population. A total of 105 inpatient drug rehab patients and 50 participants from the general population were compared based on standardized psychophysiological and psychosocial measures. Results of this study suggest that patients attending drug addiction centers differ from general population in several different psychophysiological and psychosocial factors. Patients reported significantly lower levels of physical activity and increased sympathetic responsiveness, and significantly higher levels in loneliness, psychologically inflexibility and neuroticism. The results of this study highlight the importance of address healthy lifestyle behaviors such as sport practice and psychological variables such as loneliness, psychological (in)flexibility and neuroticism to improve current programs aim to prevent or reduce problematic drug consumptions.

Inflammation in COVID-19 and the Effects of Non-Pharmacological Interventions during the Pandemic: A Review.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the coronavirus disease 2019 (COVID-19) pandemic that hit the health systems worldwide hard, causing a collapse of healthcare systems. One of the main problems of this new virus is the high inflammatory response it provokes, which is the cause of much of the symptoms. Different pharmacological approaches tried to stop the advance of the pandemic, but it seems that only vaccines are the solution. In this line, different nonpharmacological approaches have been made in order to improve symptomatology, contagion, and spread of COVID-19, the principal factors being the physical activity, nutrition, physiotherapy, psychology, and life patterns. The SARS-CoV-2 virus produces a disproportionate inflammatory response in the organism of the guest and causes complications in this that can end the life of the patient. It has been possible to see how different nonpharmacological interventions based on physical activity, nutritional, psychological, and physical therapy, and lifestyle changes can be functional tools to treat this inflammation. Thus, in the present review, we aim to provide an overview of the role of inflammation in COVID-19 and the nonpharmacological interventions related to it.

Number of finishers and performance of age group women and men in long-distance running: comparison among 10km, half-marathon and marathon races in Oslo.

The aim of the present study was to examine the number of finishers and performance trends in 10 km, half-marathon and marathon races in Oslo. Data (total 115,725 finishers; women, n = 50,595; men, n = 65,130) from 10 km, half-marathon and marathon races in Oslo from 2008 to 2018 were analysed considering number, sex, age and running speed of finishers. The total men-to-women ratio was the smallest in the 10 km race (0.60) and the largest in the marathon (3.86) (p < 0.01, φ = 0.28). In both women and men, the slowest running speed was shown in the older age groups (p < 0.01). Based on the findings of the present study, it was concluded that relatively more women finished a 10 km and less a half-marathon and a marathon. Our results indicated that the sex difference in performance was attenuated in the longer race distances and older age groups.

Portable Biosensors for Psychophysiological Stress Monitoring of a Helicopter Crew.

This study aims to analyze the psychophysiological stress response of a helicopter crew using portable biosensors, and to analyze the psychophysiological stress response differences of experienced and non-experienced crew members. We analyzed 27 participants (33.89 ± 5.93 years) divided into two different flight maneuvers: a crane rescue maneuver: 15 participants (three control and 12 military) and a low-altitude maneuver: 12 participants (five control and seven military). Anxiety, rating of perceived exertion, subjective perception of stress, heart rate, blood oxygen saturation, skin temperature, blood lactate, cortical arousal, autonomic modulation, leg and hand strength, leg flexibility, spirometry, urine, and short-term memory were analyzed before and after both helicopter flight maneuvers. The maneuvers produced a significant increase in stress and effort perception, state of anxiety, and sympathetic modulation, as well as a significant decrease in heart rate, blood oxygen saturation, leg and inspiratory muscle strength, and urine proteins. The use of biosensors showed how a crane rescue and low-altitude helicopter maneuvers produced an anticipatory anxiety response, showing an increased sympathetic autonomic modulation prior to the maneuvers, which was maintained during the maneuvers in both experienced and non-experienced participants. The crane rescue maneuver produced a higher maximal heart rate and decreased pulmonary capacity and strength than the low-altitude maneuver. The psychophysiological stress response was higher in the experienced than in non-experienced participants, but both presented an anticipatory stress response before the maneuver.

Psychophysiological Response to Disorientation Training in Different Aircraft Pilots.

Disorientation is one of the most important hazards in flights, but there is a need for a deeper analysis of its effect on the psychophysiological response of pilots. This study aimed to analyse the effect of disorientation training in cortical arousal, autonomic modulation, muscle strength, and perception. We analysed 39 male pilots of the Spanish Army and Air Force (27 Helicopter Pilots, 7 Transport Pilots and 5 F-18 Fighter Pilots) before and after disorientation training. Disorientation training produced an increase in perceived stress and effort in Helicopter Pilots (HP) and Transport Pilots (TP), and lower Heart Rate Variability (RMSSD) in all pilots. Rating of Perceived Exertion (RPE) and Handgrip Strength were more negatively affected among HP than in TP. RPE was more negatively affected in HP than among Fighter Pilots (FP). Forced Vital Capacity (FVC) and Forced Expiratory Volume in 1 s (FEV1) were significantly higher in FP (FVC 5.44 ± .407 l, FEV1 4.57 ± .407 l) than in HP (FVC 4.73 ± .547 l, FEV1 3.79 ± .712 l). Disorientation training affects the psychophysiological response of pilots, and different responses are depending on each job profile. These results could help to improve specific training for better preparation of pilots that face disorientation threats.

Could Combat Stress Affect Journalists' News Reporting? A Psychophysiological Response.

Covering war conflicts may compromise the psychological and physical health of journalists because chronic exposure to these environments has been related to depression, memory dissociative processes, and post-traumatic stress disorder; however, acute effects have not been studied yet. Thus, a combat simulation was carried out replicating actual warfare scenarios, including personnel and equipment. Psychophysiological response, memory, and information-processing were analysed of 40 professional soldiers (21 males and 19 females) and 19 journalists (12 males and 7 females) with international experience in current conflict areas such as Afghanistan, Iraq, Bosnia and Herzegovina, and Kosovo, in relation to their experience of a combat intervention. A significant increase (p < 0.05) in metabolic, muscular, cardiovascular, and cortical and psychological anxiety response, as well as a decrease in memory accuracy directly after and 24 h and 72 h post-combat were found; these modifications were modulated by the nature of the stimulus. Journalists presented higher cognitive and memory impairment than soldiers, resulting in a press reporting of real events accuracy of only 27%.

The Effect of Cultural Differences in Psychophysiological Stress Response in High Education Context: A Pilot Study.

The simulation scenarios are increasingly being used to assess professional competences in health sciences at university level. The objective of this study was to explore the effect of differences in the stress psychophysiological response of Psychology degree students from Spain and Colombia undergoing to clinical practice. Multiple psychophysiological measures were obtained in a sample of 25 Colombian and Spanish Psychology students undergoing to simulation scenario. Differences in the initial level of stress and habituation process as reported by self-reported and psychophysiological measurements as discussed. Differences in stress-related psychological traits are also analyzed and further discussed.

Psychophysiological Stress Response of Novice Cavers in a Speleology Route.

INTRODUCTION: Speleology/Caving is a recreational outdoor activity that has drawn an increasing number of participants in recent years, but there is little information on the physiological and psychological demands of this outdoor activity. This research aimed to analyze the psychophysiological response of novice cavers to a caving route. METHODS: Modifications in autonomic modulation, ratings of perceived exertion, and perceived stress were evaluated in physically active participants before, during, and after a caving route of 3-h duration. RESULTS: Eighteen participants were assessed. We found an anticipatory anxiety response in the participants before starting the route and significant increases in the ratings of perceived exertion, stress perception, autonomous sympathetic modulation as evaluated by heart rate variability while on the route, and sympathetic modulation 30 min after finishing the caving route. CONCLUSIONS: A speleology route produced an anticipatory anxiety response, an increase in the sympathetic stress response, fatigue symptoms at the autonomic nervous system level, and low perception of stress and effort compared with the autonomic stress response. This information could help to better prepare participants for this demanding event, potentially avoiding accidents and injuries and increasing safety for cavers.

Psychophysiological response in night and instrument helicopter flights.

Instrument and night flights are sources of mishaps: they produce stressful contexts to aircrews in which operability can be affected. This study aimed to analyse the effect of night and instrument flights in cortical arousal, autonomic modulation, muscle strength, and stress perception. 23 people were analysed (8 helicopter pilots, 4 helicopter mechanics - Spanish Air Forces - and 11 controls) before and after instrument and night flight exposition. Lactate and perceived exertion rose after flights. Anxiety was higher in instrument than in night flights. Pilots had a higher sense of anxiety before a flight compared to mechanics, although mechanics experienced a higher raise of heart rate during flight, with lower heart rate variability. Breath capacity was affected in pilots. Cortical arousal was more affected in unexperienced than in experienced aircrew during flights. These data suggest differences in their previous training. Practitioner summary: Night and instrument helicopter flights produced a different psychophysiological response of aircrew. These results could help to design specific training for aircrew that usually face instrument and night manoeuvres. Specific training based on high-intensity interval training integrated with reverse periodisation could improve their preparation. Abbreviations: BMI: body mass index; BOS: blood oxygen saturation; BT: body temperature; CA: cognitive anxiety; CFFT: critical flicker fusion threshold; ES: effect size; FEV1: forced expiratory volume in 1 second; FVC: forced vital capacity; HF: high frequency; HR: heart rate; HRV: heart rate variability; HIS: isometric handgrip strength; LF: low frequency; NVG: night vision googles; PEF: peak expiratory flow; pNN50: proportion of differences between R-R intervals higher than 50 ms; RMSSD: square root of the mean of the sum of the squared differences between adjacent normal R-R intervals; RPE: rated of perceived exertion; SA: somatic anxiety; SC: self confidence; STAI: state trait anxiety inventory.

Evaluation of Central Fatigue by the Critical Flicker Fusion Threshold in Cyclists.

Central fatigue related in sport stimuli was studied by Critical Flicker Fusion Threshold (CFFT) to know the influence of exercise on the central nervous system (CNS), but there is a lack of knowledge about the central or peripheral fatigue in endurance events. This study aimed to analyze changes in CFFT before and after the incremental cycle ergometer test as a means to assess the fatigue of the CNS. CFFT ascending and descending, the subjective criterion and sensory sensitivity were analysed in 8 professional male cyclists (72.1 ± 5.59 kg, 180.3 ± 6.43 cm, 17.4 ± 0.7 years) before and after a maximum incremental cycle ergometer test (start 50w increases 50w each 5 min). In this incremental test, the induced fatigue was probably more a peripheral phenomenon than one due to central nervous system fatigue, because sensory sensitivity did not significantly decrease. In conclusion, an incremental cycle ergometer test increased the cortical arousal and does not affect negatively the CNS of professional cyclists.

Psychophysiological and Specific Fine Motor Skill Modifications in a Checkpoint Action.

In last years, the insurgency attacks on task forces bases and checkpoints have been common. The study of psychophysiological response of soldiers in these asymmetrical and non-controlled situations remains a challenge. The present research aimed to analyze the psychophysiological response and the variations in specific fine motor skill after a checkpoint simulation which included surveillance, unexpected attacks, and melee combat. Psychophysiological parameters -heart rate, blood glucose, pressure, oxygen saturation, and lactate, legs´ strength, skin temperature, cortical activation, anxiety-, as well as fine motor skills were analyzed in a sample of 24 professional Spanish Army soldiers (35.67 ± 6.62 years, 177.21 ± 7.37 cm, 82.29 ± 11.02 kg, 26.17 ± 2.82 BMI, 15.25 ± 7.44 years of experience in their unit) before and after a checkpoint simulation. The checkpoint surveillance operation produced a significant increase (p < 0.05) in rated perceived exertion, heart rate, blood lactate concentration, legs´ strength and somatic anxiety, and a significant decrease in blood oxygen saturation and skin temperature values. We concluded that results were consistent with an activation of sympathetic nervous system, triggering a fight-flight response, a chain of intense psychophysiological reactions and a misinterpretation of perceived exertion. Results may help predicting soldiers´ physical and operative behavior in real situations.

Psychophysiological Stress Response of a Paralympic Athlete During an Ultra-Endurance Event. A Case Study.

Psychophysiological response of athletes with spinal cord injurie has not been reported yet in scientific literature. The aim of this study is to examine the psychophysiological stress response of Paralympic athlete during competitive activities. We collected the following psychophysiological measurements: anxiety-trait, anxiety-state, locus of control, perceived psychological stress, stress-copying style, rate of perceived exertion, perceived muscle pain, body temperature, forced vital capacity, blood oxygen saturation, blood glucose and lactate concentrations, isometric hand strength, cortical arousal, heart rate variability, heart rate and velocities of a female Paralympic spinal cord injured athlete in a 11 h and 44 min ultraendurance mountain event. An ultraendurance mountain even produced an increase in the sympathetic autonomous modulation, heart rate, lactate, muscular pain and rated of perceived exertion and a decrease in cortical arousal, hand strength and respiratory muscle in a spinal cord injurie female athlete during. The Paralympic athletes presented a low psychological inflexibility, high life engagement, strong internal locus of control, a low trait and state anxiety and medium perceived psychological stress. These results are consistent with the expected response during a highly stressful situation and consistent with previous findings in athletes without spinal cord injurie.

Effect of Experience and Psychophysiological Modification by Combat Stress in Soldier's Memory.

The present research aimed to analyze the effect of experience and psychophysiological modification by combat stress in soldier's memory in a simulated combat situation. Variables of rate of perceived exertion, blood glucose, blood lactate, lower body muscular strength manifestation, cortical arousal, specific fine motor skills, autonomic modulation, state anxiety, and memory and attention through a postmission questionnaire were analyzed before and after a combat simulation in 15 experienced soldiers of a special operation unit and 20 non-experienced soldiers of light infantry unit from the Spanish Army. The stress of combat simulation produces a significant increase (p < 0.05) in rated perceived exertion, blood glucose, blood lactate, somatic anxiety and a low frequency domain of the heart rate, and a significant decrease of rifle magazine reload time, high frequency domain of the heart rate and somatic anxiety in both groups. The variables of RPE, glucose, CFFT, RMRT, RMSSD, LF/HF, CA, SA and STAI were significantly different in experienced soldiers shown the activation of fight-flight system. The anticipatory anxiety in experienced soldiers shows a cognitive behavioral association by past experiences. The analysis of correct response in the postmission questionnaire show elements more related with the sight and that endanger the physical integrity of soldiers are more remembered, and some significant differences (p < 0.05) in the memory performance of experienced soldiers and non experienced soldiers where experienced soldiers shown a better performance. As conclusion, combat stress produce an increase in the psichophysiological response of soldiers independently of experience, but experienced ones presented a lower negative effect on memory than non experienced.

Analysis of Psychophysiological Stress Response in Higher Education Students Undergoing Clinical Practice Evaluation.

The aim of this study was to analyze the psychophysiological response of Physiotherapy degree students during a complete clinical practice as well as their psychological profile in relation to coping style in stressful situations, and its impact on academic performance. We analysed in 15 students heart rate variability (HRV) to analyse autonomic modulation in three moments during the entire clinical practices of 3 months (4 h per day, 3 days per week), first session, middle session and last session; perceived stress, personality, life engagement, cognitive flexibility before starting the clinical practice the academic performance after the clinical practice. Results based on HRV and related indexes parameters fail to indicate the expected autonomic adaptation during the practice. A complete clinical practice of Physiotherapy degree students did not produce an habituation process since a high sympathetic autonomic nervous system modulation was measured in the beginning, at the middle and at the final of the clinical practice. Below-average scores are presented in a personality factor associated with traditional and non-adaptive coping styles that could explain the non-habituation of the students. Finally, none of the analyzed indexes has been able to relate to academic performance.

Psychophysiological response of different aircrew in normobaric hypoxia training.

Hypoxia remains the most important hazard in high altitude flights, but there is still a need for deeper analysis of the effect of hypoxia exposition in the psychophysiological and cognitive functions. The aim of this study was to study the effect of hypoxia training in cortical arousal, autonomic modulation, muscle strength and cognitive function. We analysed 23 male aircrew personnel of the Spanish Army and Air Force (10 Helicopter Pilots, 7 Transport Aircrew, 3 Transport Pilots and 3 F-18 Fighter Pilots) before, during and after a normobaric hypoxia exposition. Hypoxia produced an increase in perceived stress and effort, a higher Heart Rate and a decreased function of breath muscles. Working memory and pattern recognition were impaired after hypoxia exposition. Significant differences were found in cognitive tests performance among aircrew groups, suggesting differences on their previous training. These results can improve specific training for better preparation of pilots and aircrews for hypoxic threats. Practitioner summary: Distinct aircrew preparation produces a different hypoxia exposition effect on psychophysiological response and cognitive functions. Hypoxia produced an increase in Heart Rate, a decreased function of breath muscles, being more negatively affected in Transport Pilots. Cognition abilities were impaired after hypoxia exposition, independently of the aircrew group.

Autonomic Adaption to Clinical Simulation in Psychology Students: Teaching Applications.

Simulation is used to facilitate new learning in a variety of situations. One application of simulation could be to help therapists gain therapeutic skills prior to seeing clients. This particular study was interested in measuring changes in stress response by looking at subjective and objective measures of distress (as measured by SUDS, HR, and HRV) over three sessions of simulated therapy. 16 second year psychology students participated in three sessions, and had their HR and HRV measured by Polar watches. Over the three sessions, there was a decrease in perceived distress, as measured by SUDS ratings. During and between sessions, there was inconclusive change in physiological parameters.

Psychophysiological, Body Composition, Biomechanical and Autonomic Modulation Analysis Procedures in an Ultraendurance Mountain Race.

The current research aimed to analyze psychophysiological, body composition, biomechanical and autonomic modifications in an ultraendurance mountain race. We analyzed 11 finisher voluntary athletes that participated in a 51.2 km ultraendurance mountain race. We measured before and after the mountain ultraendurance event the following parameters: Rate of perceived exertion, body composition, cortical arousal, blood pressure, body temperature, forced vital capacity, blood oxygen saturation, isometric hand strength and heart rate variability parameters. The results of temperature, rate of perceived exertion, heart rate and the percentage of body water at the end of the race increased significantly. However, the variables of body weight, body fat, muscle, body mass index, abdominal fat, blood oxygen saturation, systolic and diastolic blood pressure, cortical arousal and hands and legs strength significantly decreased after the race. The square root of the average of the sum of the differences squared between normal adjacent R-R intervals, percentage of differences between normal adjacent R-R intervals, high-frequency, sensitivity of the short-term variability, and long-term variability decreased significantly after the race. By contrary low-frequency increased significantly at the end of the race. An ultraendurance mountain event produced a large anticipatory anxiety response, an increase in sympathetic modulation, body fat consumption, percentage of body water, and RPE, not affecting the cortical arousal.