Detalhe da pesquisa
1.
SAR evolution towards potent C-terminal carboxamide peptide inhibitors of Zika virus NS2B-NS3 protease.
Bioorg Med Chem
; 57: 116631, 2022 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35123179
2.
Optimization of linear and cyclic peptide inhibitors of KEAP1-NRF2 protein-protein interaction.
Bioorg Med Chem
; 28(21): 115738, 2020 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33065433
3.
Guiding Chemically Synthesized Peptide Drug Lead Optimization by Derisking Mast Cell Degranulation-Related Toxicities of a NaV1.7 Peptide Inhibitor.
Toxicol Sci
; 185(2): 170-183, 2022 01 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-34897513
4.
Development of ProTx-II Analogues as Highly Selective Peptide Blockers of Nav1.7 for the Treatment of Pain.
J Med Chem
; 65(1): 485-496, 2022 01 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-34931831
5.
Combined Peptide and Small-Molecule Approach toward Nonacidic THIQ Inhibitors of the KEAP1/NRF2 Interaction.
ACS Med Chem Lett
; 11(5): 740-746, 2020 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-32435379
6.
2-(2-Thienyl)-5,6-dihydroxy-4-carboxypyrimidines as inhibitors of the hepatitis C virus NS5B polymerase: discovery, SAR, modeling, and mutagenesis.
J Med Chem
; 49(5): 1693-705, 2006 Mar 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-16509585
7.
Phenethyl amides as novel noncovalent inhibitors of hepatitis C virus NS3/4A protease: discovery, initial SAR, and molecular modeling.
J Med Chem
; 46(3): 345-8, 2003 Jan 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-12540231
8.
Discovery of (7R)-14-cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylic acid (MK-3281), a potent and orally bioavailable finger-loop inhibitor of the hepatitis C virus NS5B polymerase.
J Med Chem
; 54(1): 289-301, 2011 Jan 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-21141896
9.
Optimization of thienopyrrole-based finger-loop inhibitors of the hepatitis C virus NS5B polymerase.
ChemMedChem
; 4(10): 1695-713, 2009 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-19672916
10.
Active site inhibitors of HCV NS5B polymerase. The development and pharmacophore of 2-thienyl-5,6-dihydroxypyrimidine-4-carboxylic acid.
Bioorg Med Chem Lett
; 14(20): 5085-8, 2004 Oct 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-15380204
11.
Evolution, synthesis and SAR of tripeptide alpha-ketoacid inhibitors of the hepatitis C virus NS3/NS4A serine protease.
Bioorg Med Chem Lett
; 12(4): 705-8, 2002 Feb 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-11844706
12.
A designed P1 cysteine mimetic for covalent and non-covalent inhibitors of HCV NS3 protease.
Bioorg Med Chem Lett
; 12(4): 701-4, 2002 Feb 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-11844705
13.
SAR and pharmacokinetic studies on phenethylamide inhibitors of the hepatitis C virus NS3/NS4A serine protease.
Bioorg Med Chem Lett
; 14(17): 4575-9, 2004 Sep 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-15357995