Detalhe da pesquisa
1.
Synthesis and Biological Evaluation of (2S,2'S)-Lomaiviticin A.
J Am Chem Soc
; 143(2): 1126-1132, 2021 01 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-33410680
2.
Bithionol Potently Inhibits Human Soluble Adenylyl Cyclase through Binding to the Allosteric Activator Site.
J Biol Chem
; 291(18): 9776-84, 2016 Apr 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-26961873
3.
Synergistic potentiation of (-)-lomaiviticin A cytotoxicity by the ATR inhibitor VE-821.
Bioorg Med Chem Lett
; 26(13): 3122-3126, 2016 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27177826
4.
Mechanism of action studies of lomaiviticin A and the monomeric lomaiviticin aglycon. Selective and potent activity toward DNA double-strand break repair-deficient cell lines.
J Am Chem Soc
; 137(17): 5741-7, 2015 May 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-25849366
5.
Mutational specificity of gamma-radiation-induced guanine-thymine and thymine-guanine intrastrand cross-links in mammalian cells and translesion synthesis past the guanine-thymine lesion by human DNA polymerase eta.
Biochemistry
; 47(31): 8070-9, 2008 Aug 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-18616294
6.
Specific and efficient binding of xeroderma pigmentosum complementation group A to double-strand/single-strand DNA junctions with 3'- and/or 5'-ssDNA branches.
Biochemistry
; 45(51): 15921-30, 2006 Dec 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-17176115
7.
Synthesis of N2 2'-deoxyguanosine adducts formed by 1-nitropyrene.
Org Lett
; 5(16): 2861-4, 2003 Aug 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-12889893
8.
Small molecule BMH-compounds that inhibit RNA polymerase I and cause nucleolar stress.
Mol Cancer Ther
; 13(11): 2537-46, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-25277384
9.
DNA intercalator BMH-21 inhibits RNA polymerase I independent of DNA damage response.
Oncotarget
; 5(12): 4361-9, 2014 Jun 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-24952786
10.
The cytotoxicity of (-)-lomaiviticin A arises from induction of double-strand breaks in DNA.
Nat Chem
; 6(6): 504-10, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24848236
11.
A targeting modality for destruction of RNA polymerase I that possesses anticancer activity.
Cancer Cell
; 25(1): 77-90, 2014 Jan 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24434211
12.
Design, synthesis, and structure-activity relationships of pyridoquinazolinecarboxamides as RNA polymerase I inhibitors.
J Med Chem
; 57(11): 4950-61, 2014 Jun 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-24847734
13.
Proteasome activity influences UV-mediated subnuclear localization changes of NPM.
PLoS One
; 8(3): e59096, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23554979
14.
Identification of novel p53 pathway activating small-molecule compounds reveals unexpected similarities with known therapeutic agents.
PLoS One
; 5(9): e12996, 2010 Sep 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-20885994
15.
Synthesis of oligonucleotides containing 2'-deoxyguanosine adducts of nitropyrenes.
Nucleosides Nucleotides Nucleic Acids
; 28(2): 67-77, 2009 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-19219737
16.
Recognition and incision of gamma-radiation-induced cross-linked guanine-thymine tandem lesion G[8,5-Me]T by UvrABC nuclease.
Chem Res Toxicol
; 18(9): 1339-46, 2005 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-16167825