Detalhe da pesquisa
1.
Preclinical evaluation of FLT190, a liver-directed AAV gene therapy for Fabry disease.
Gene Ther
; 30(6): 487-502, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-36631545
2.
RNAi prevents and reverses phenotypes induced by mutant human ataxin-1.
Ann Neurol
; 80(5): 754-765, 2016 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-27686464
3.
Differences in wild-type- and R338L-tenase complex formation are at the root of R338L-factor IX assay discrepancies.
Blood Adv
; 7(3): 458-467, 2023 02 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35839077
4.
HCV-NS3 inhibitors: determination of their kinetic parameters and mechanism.
Biochim Biophys Acta
; 1794(10): 1441-8, 2009 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-19505593
5.
Lersivirine, a nonnucleoside reverse transcriptase inhibitor with activity against drug-resistant human immunodeficiency virus type 1.
Antimicrob Agents Chemother
; 54(10): 4451-63, 2010 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-20660667
6.
Pyrazole NNRTIs 1: design and initial optimisation of a novel template.
Bioorg Med Chem Lett
; 19(19): 5599-602, 2009 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19709880
7.
Pyrazole NNRTIs 4: selection of UK-453,061 (lersivirine) as a development candidate.
Bioorg Med Chem Lett
; 19(20): 5857-60, 2009 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19748778
8.
Pyrazole NNRTIs 3: optimisation of physicochemical properties.
Bioorg Med Chem Lett
; 19(19): 5603-6, 2009 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19717303
9.
Pharmacokinetics and safety in cynomolgus monkeys of a monoclonal antibody targeting human scavenger receptor class B type-1 for hepatitis C treatment.
Antivir Ther
; 18(6): 775-84, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23702590
10.
Identification of novel FLT3 kinase inhibitors.
Eur J Med Chem
; 63: 713-21, 2013 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-23567961
11.
Comparison of the non-nucleoside reverse transcriptase inhibitor lersivirine with its pyrazole and imidazole isomers.
Chem Biol Drug Des
; 77(5): 393-7, 2011 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-21352504
12.
Novel indazole non-nucleoside reverse transcriptase inhibitors using molecular hybridization based on crystallographic overlays.
J Med Chem
; 52(4): 1219-23, 2009 Feb 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-19175319
13.
Optimization of 5-aryloxyimidazole non-nucleoside reverse transcriptase inhibitors.
ChemMedChem
; 3(11): 1756-62, 2008 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-18855969
14.
Characterization of fusion determinants points to the involvement of three discrete regions of both E1 and E2 glycoproteins in the membrane fusion process of hepatitis C virus.
J Virol
; 81(16): 8752-65, 2007 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-17537855
15.
Regulation of minute virus of mice NS1 replicative functions by atypical PKClambda in vivo.
J Virol
; 77(1): 433-42, 2003 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-12477848