Detalhe da pesquisa
1.
Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2.
Proc Natl Acad Sci U S A
; 120(2): e2212931120, 2023 01 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36598939
2.
A single inactivating amino acid change in the SARS-CoV-2 NSP3 Mac1 domain attenuates viral replication in vivo.
PLoS Pathog
; 19(8): e1011614, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37651466
3.
Overcoming insecticide resistance through computational inhibitor design.
Proc Natl Acad Sci U S A
; 116(42): 21012-21021, 2019 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31575743
4.
The role of protein dynamics in the evolution of new enzyme function.
Nat Chem Biol
; 12(11): 944-950, 2016 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-27618189
5.
Conformational Disorganization within the Active Site of a Recently Evolved Organophosphate Hydrolase Limits Its Catalytic Efficiency.
Biochemistry
; 55(9): 1408-17, 2016 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-26881849
6.
Structural characterization of ligand binding and pH-specific enzymatic activity of mouse Acidic Mammalian Chitinase.
bioRxiv
; 2024 Mar 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-37398339
7.
A single inactivating amino acid change in the SARS-CoV-2 NSP3 Mac1 domain attenuates viral replication and pathogenesis in vivo.
bioRxiv
; 2023 May 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37131711
8.
Of problems and opportunities-How to treat and how to not treat crystallographic fragment screening data.
Protein Sci
; 31(9): e4391, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36040268
9.
The mechanisms of catalysis and ligand binding for the SARS-CoV-2 NSP3 macrodomain from neutron and X-ray diffraction at room temperature.
bioRxiv
; 2022 Feb 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35169801
10.
The mechanisms of catalysis and ligand binding for the SARS-CoV-2 NSP3 macrodomain from neutron and x-ray diffraction at room temperature.
Sci Adv
; 8(21): eabo5083, 2022 May 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-35622909
11.
Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 Macrodomain of SARS-CoV-2.
bioRxiv
; 2022 Jul 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-35794891
12.
Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking.
Sci Adv
; 7(16)2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33853786
13.
Fragment Binding to the Nsp3 Macrodomain of SARS-CoV-2 Identified Through Crystallographic Screening and Computational Docking.
bioRxiv
; 2020 Nov 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-33269349
14.
Laboratory evolution of protein conformational dynamics.
Curr Opin Struct Biol
; 50: 49-57, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29120734
15.
Molecular basis for the behavioral effects of the odorant degrading enzyme Esterase 6 in Drosophila.
Sci Rep
; 7: 46188, 2017 04 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28393888
16.
Mapping the Accessible Conformational Landscape of an Insect Carboxylesterase Using Conformational Ensemble Analysis and Kinetic Crystallography.
Structure
; 24(6): 977-87, 2016 06 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27210287
17.
Evolution of Protein Quaternary Structure in Response to Selective Pressure for Increased Thermostability.
J Mol Biol
; 428(11): 2359-2371, 2016 06 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-27016206