Detalhe da pesquisa
1.
Dissecting Parameters Contributing to the Underprediction of Aldehyde Oxidase-Mediated Metabolic Clearance of Drugs.
Drug Metab Dispos
; 51(10): 1362-1371, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37429730
2.
Optimization of genetic code expansion in the baculovirus expression vector system (BEVS).
Protein Expr Purif
; 210: 106314, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37269916
3.
Production of active recombinant human aldehyde oxidase (AOX) in the baculovirus expression vector system (BEVS) and deployment in a pre-clinical fraction-of-control AOX compound exposure assay.
Protein Expr Purif
; 177: 105749, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32911062
4.
Axitinib effectively inhibits BCR-ABL1(T315I) with a distinct binding conformation.
Nature
; 519(7541): 102-5, 2015 Mar 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-25686603
5.
Multiple conformational states of the HPK1 kinase domain in complex with sunitinib reveal the structural changes accompanying HPK1 trans-regulation.
J Biol Chem
; 294(23): 9029-9036, 2019 06 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31018963
6.
High-volume shake flask cultures as an alternative to cellbag technology for recombinant protein production in the baculovirus expression vector system (BEVS).
Protein Expr Purif
; 165: 105496, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31518639
7.
Corrigendum to 'Production of active recombinant human aldehyde oxidase (AOX) in the baculovirus expression vector system (BEVS) and deployment in a pre-clinical fraction-of-control AOX compound exposure assay' [Protein Expr. Purif. 177 (2020) 105749].
Protein Expr Purif
; 179: 105769, 2021 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-33127220
8.
Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1.
Biochem J
; 444(1): 79-88, 2012 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22397330
9.
Design and Synthesis of Functionally Active 5-Amino-6-Aryl Pyrrolopyrimidine Inhibitors of Hematopoietic Progenitor Kinase 1.
J Med Chem
; 66(7): 4888-4909, 2023 04 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-36940470
10.
Synthesis of Deuterated Heterocycles with Me2NCD(OMe)2 and Evaluation of the Products for Metabolism by Aldehyde Oxidase.
ACS Med Chem Lett
; 13(2): 250-256, 2022 Feb 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35178182
11.
Study of the PDK1/AKT signaling pathway using selective PDK1 inhibitors, HCS, and enhanced biochemical assays.
Anal Biochem
; 414(2): 179-86, 2011 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21402045
12.
Crystal structure of a novel dimeric form of NS5A domain I protein from hepatitis C virus.
J Virol
; 83(9): 4395-403, 2009 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-19244328
13.
Biochemical characterization of recombinant hepatitis C virus nonstructural protein 4B: evidence for ATP/GTP hydrolysis and adenylate kinase activity.
Biochemistry
; 48(5): 906-16, 2009 Feb 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-19146391
14.
Discovery of Allosteric, Potent, Subtype Selective, and Peripherally Restricted TrkA Kinase Inhibitors.
J Med Chem
; 62(1): 247-265, 2019 01 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29672039
15.
Small molecule inhibitors reveal PTK6 kinase is not an oncogenic driver in breast cancers.
PLoS One
; 13(6): e0198374, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29879184
16.
Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain.
J Med Chem
; 61(15): 6779-6800, 2018 08 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29944371
17.
Production of selenomethionyl-derivatized proteins in baculovirus-infected insect cells.
Protein Sci
; 16(9): 2023-9, 2007 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-17660253
18.
Structures of the cancer-related Aurora-A, FAK, and EphA2 protein kinases from nanovolume crystallography.
Structure
; 10(12): 1659-67, 2002 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-12467573
19.
Development of a high-throughput crystal structure-determination platform for JAK1 using a novel metal-chelator soaking system.
Acta Crystallogr F Struct Biol Commun
; 72(Pt 11): 840-845, 2016 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27827355
20.
Economical parallel protein expression screening and scale-up in Escherichia coli.
J Struct Funct Genomics
; 7(2): 101-8, 2006 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-17187226