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1.
Neuroimage ; 107: 10-22, 2015 Feb 15.
Artigo em Inglês | MEDLINE | ID: mdl-25479021

RESUMO

The human brain responds both before and during the application of aversive stimuli. Anticipation allows the organism to prepare its nociceptive system to respond adequately to the subsequent stimulus. The context in which an uncomfortable stimulus is experienced may also influence neural processing. Uncertainty of occurrence, timing and intensity of an aversive event may lead to increased anticipatory anxiety, fear, physiological arousal and sensory perception. We aimed to identify, in healthy volunteers, the effects of uncertainty in the anticipation of uncomfortable rectal distension, and the impact of the autonomic nervous system (ANS) activity and anxiety-related psychological variables on neural mechanisms of anticipation of rectal distension using fMRI. Barostat-controlled uncomfortable rectal distensions were preceded by cued uncertain or certain anticipation in 15 healthy volunteers in a fMRI protocol at 3T. Electrocardiographic data were concurrently registered by MR scanner. The low frequency (LF)-component of the heart rate variability (HRV) time-series was extracted and inserted as a regressor in the fMRI model ('LF-HRV model'). The impact of ANS activity was analyzed by comparing the fMRI signal in the 'standard model' and in the 'LF-HRV model' across the different anticipation and distension conditions. The scores of the psychological questionnaires and the rating of perceived anticipatory anxiety were included as covariates in the fMRI data analysis. Our experiments led to the following key findings: 1) the subgenual anterior cingulate cortex (sgACC) is the only activation site that relates to uncertainty in healthy volunteers and is directly correlated to individual questionnaire score for pain-related anxiety; 2) uncertain anticipation of rectal distension involved several relevant brain regions, namely activation of sgACC and medial prefrontal cortex and deactivation of amygdala, insula, thalamus, secondary somatosensory cortex, supplementary motor area and cerebellum; 3) most of the brain activity during anticipation, but not distension, is associated with activity of the central autonomic network. This approach could be applied to study the ANS impact on brain activity in various pathological conditions, namely in patients with chronic digestive conditions characterized by visceral discomfort and ANS imbalance such as irritable bowel syndrome or inflammatory bowel diseases.


Assuntos
Antecipação Psicológica/fisiologia , Sistema Nervoso Autônomo/fisiologia , Reto/fisiologia , Adulto , Ansiedade/psicologia , Encéfalo/fisiologia , Sinais (Psicologia) , Eletrocardiografia , Feminino , Giro do Cíngulo/fisiologia , Voluntários Saudáveis , Frequência Cardíaca/fisiologia , Humanos , Imageamento por Ressonância Magnética , Masculino , Rede Nervosa/fisiologia , Nociceptividade/fisiologia , Dor/fisiopatologia , Estimulação Física , Reto/inervação , Incerteza , Adulto Jovem
2.
Aging Ment Health ; 16(7): 922-30, 2012.
Artigo em Inglês | MEDLINE | ID: mdl-22533476

RESUMO

Short-term and working memory (WM) capacities are subject to change with ageing, both in normal older adults and in patients with degenerative or non-degenerative neurological disease. Few normative data are available for comparisons of short-term and WM capacities in the verbal, spatial and visual domains. To provide researchers and clinicians with a set of standardised tasks that assess short-term and WM using verbal and visuospatial materials, and to present normative data for that set of tasks. The present study compiled normative French data for three short-term memory tasks (verbal, visual and spatial simple span tasks) and two WM tasks (verbal and spatial complex span tasks) obtained from 445 healthy older adults aged between 55 and 85 years. Our data reveal main effects of age, education level and gender on older adults' short-term and WM performances. Equation-based normalisation can therefore be used to take these factors into account. The results provide a set of cut-off scores for five standardised tasks that can be used to determine the presence of short-term or WM impairment in older adults.


Assuntos
Envelhecimento/psicologia , Memória de Curto Prazo , Idoso , Idoso de 80 Anos ou mais , Escolaridade , Feminino , França , Humanos , Masculino , Pessoa de Meia-Idade , Valores de Referência , Fatores Sexuais , Análise e Desempenho de Tarefas
3.
Cogn Emot ; 26(3): 568-76, 2012.
Artigo em Inglês | MEDLINE | ID: mdl-21851154

RESUMO

According to the Appraisal-Tendency Framework (Han, Lerner, & Keltner, 2007), certainty-associated emotions increase risk taking compared with uncertainty-associated emotions. To date, this general effect has only been shown in static judgement and decision-making paradigms; therefore, the present study tested the effect of certainty on risk taking in a sequential decision-making task. We hypothesised that the effect would be reversed due to the kind of processing involved, as certainty is considered to encourage heuristic processing that takes into account the emotional cues arising from previous decisions, whereas uncertainty leads to more systematic processing. One hundred and one female participants were induced to feel one of three emotions (film clips) before performing a decision-making task involving risk (Game of Dice Task; Brand et al., 2005). As expected, the angry and happy participants (certainty-associated emotions) were more likely than the fearful participants (uncertainty-associated emotion) to make safe decisions (vs. risky decisions).


Assuntos
Ira , Medo , Felicidade , Assunção de Riscos , Incerteza , Adulto , Tomada de Decisões , Feminino , Humanos , Estimulação Luminosa/métodos , Desempenho Psicomotor
4.
Front Psychol ; 13: 996559, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36571039

RESUMO

Objective: Since the beginning of COVID-19 pandemic, several studies have shown an increase of psychological distress in the general population. Previous research demonstrated that high levels of anxiety are associated with reporting more somatic symptoms. The ability to adaptively regulate emotions is essential to deal with stressful situations, and it is one of the main components of mindfulness practice. The aim of the present study was to document the effect of mindfulness practice on somatic symptoms and psychological distress in the context of COVID-19 pandemic. Methods: The study has a descriptive cross-sectional design. During the second wave of COVID-19 pandemic, between November 2020 and January 2021 participants living in France responded to an online survey on the impact of COVID-19 on psychological distress and physical health. The questionnaire included the assessment of COVID-19-related anxiety, mindfulness practice and experience, dispositional mindfulness, somatization, depression, generalized anxiety, and emotion regulation. Results: A total of 569 people (mean age = 39.8 years, 90% women) were included in the study. COVID-19 related anxiety was associated with higher levels of somatic symptoms, generalized anxiety, and depression. About half of the sample (n = 318, 56%) reported moderate to severe somatic symptoms that were associated with higher levels of depression and anxiety, lower levels of dispositional mindfulness and to the use of maladaptive emotion regulation strategies. Overall, 164 subjects (28.8%) reported practicing meditation. No differences were found in dispositional mindfulness (MAAS score) between beginners and advanced practitioners, regardless of the type, years, frequency, and length of practice. Participants with less experience in mindfulness practice reported a significant higher number of somatic symptoms than non-practitioners and a higher use of rumination. Moreover, mindfulness experience was associated with the use of more adaptive emotion regulation strategies. Conclusion: Mindfulness meditation has been promoted as a practice enhancing well-being and helping to cope with the psychological impact of stressful events. However, in a distressing situation as COVID-19 pandemic, a limited experience in mindfulness practices might result in the development or endurance of somatic symptoms. Adequate training and a focus on mindful acceptance, may contribute to enhance the effectiveness of mindfulness practice.

5.
Front Psychiatry ; 11: 229, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32300314

RESUMO

Alexithymia is usually described by three main dimensions difficulty identifying feelings (DIF), difficulty describing feelings (DDF), and externally oriented thinking (EOT). The most commonly used questionnaire investigating alexithymia, the Toronto Alexithymia Scale (TAS-20), supports this three-factor structure. One important assumption is that alexithymia severity is associated to vulnerability to somatic diseases, among them gastrointestinal disorders. However, the association between alexithymia and gastrointestinal disorders is not systematic, thus questioning the role of alexithymia as a vulnerability factor for those illnesses. A recent factor analysis suggested another four-factor structure for the TAS-20: difficulties in awareness of feelings (DAF), difficulties in interoceptive abilities (DIA), externally oriented thinking (EOT), and poor affective sharing (PAS). We assume that DIA and DAF might be more relevant to investigate the association between alexithymia and gastrointestinal disorders. The rationale is that DIA and DAF reflect impairments in emotion regulation that could contribute to an inappropriate autonomic and HPA axis homeostasis in irritable bowel syndrome (IBS), ulcerative colitis (UC), or Crohn's disease (CD). The aim of this study was to investigate whether DIA and DAF are associated with the presence of IBS, UC or CD, while checking for anxiety, depression, parasympathetic (vagus nerve) activity and cortisol levels. We recruited control participants (n=26), and patients in remission who were diagnosed with IBS (n=24), UC (n=18), or CD (n=21). Participants completed questionnaires to assess anxiety, depression, and alexithymia. A blood sample and an electrocardiogram were used to measure the level of cortisol and parasympathetic activity, respectively. Logistic regressions with the four-factor structure of the TAS-20 revealed that DIA was a significant predictor of IBS (W(1)=6.27, p=.01). Conversely, DIA and DAF were not significant predictors in CD and UC patients. However, low cortisol level was a significant predictor of UC (W(1)=4.67, p=.035). Additional logistic regressions based on the original 3-factor structure of TAS-20 (DIF, DDF, and EOT) showed that only DDF was a significant predictor of CD [W(1)=6.16, p < .001]. The present study suggests that DIA is an important dimension for assessing potential risk for gastrointestinal diseases, in particular for IBS.

6.
J Stud Alcohol ; 67(6): 837-40, 2006 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-17061000

RESUMO

OBJECTIVE: The objective of this study was to determine whether the nonlinear association between alcohol and depressive symptoms observed in middle-aged and older men and women is present in young adults and is independent of culture, socioeconomic position, and health status. METHOD: Data were from the International Health and Behaviour Survey, involving 6,932 male and 8,816 female university students ages 17-30 years from 20 countries. Alcohol consumption was assessed in terms of number of drinks per week and number of drinks per episode, and the Beck Depression Inventory (BDI) was administered. Analyses were adjusted for clustering by country. RESULTS: The proportion of respondents with elevated BDI scores was 19.3%, 16.3%, and 20.0% for nondrinkers, moderate drinkers, and heavy drinkers, respectively. The odds of elevated BDI scores for nondrinkers compared with moderate drinkers were 1.22 (95% confidence interval [CI]: 1.06-1.42) after adjusting for age, gender, living arrangements, socioeconomic status, and self-rated health. Analysis based on the number of alcoholic drinks consumed in the past 2 weeks indicated that, in comparison with those who consumed 5-13 drinks, the odds of elevated BDI scores for nondrinkers were 1.25 (CI: 1.02-1.53) after adjusting for the same covariates. Heavy drinkers also had higher BDI scores than moderate consumers. CONCLUSIONS: The results suggest that the "U"-shaped association between alcohol consumption and depressive symptoms previously identified in Western countries is present in young people from a variety of cultural backgrounds. The relationship is not secondary to variations in health status, socioeconomic background, age, and gender.


Assuntos
Consumo de Bebidas Alcoólicas/epidemiologia , Depressão/epidemiologia , Adolescente , Adulto , Feminino , Nível de Saúde , Humanos , Internacionalidade , Masculino , Fatores Socioeconômicos
7.
J Am Coll Health ; 55(2): 83-9, 2006.
Artigo em Inglês | MEDLINE | ID: mdl-17017304

RESUMO

The authors studied the prevalence of heavy drinking among students in 21 developed and developing countries using an anonymous survey of 7,846 male and 9,892 female students aged 17 to 30 years. There were wide variations in the prevalence of drinking among countries, and the highest rates of heavy drinking (defined as 5 or more drinks for men and 4 or more drinks for women on at least 1 occasion over the past 2 weeks) were reported in Belgium, Colombia, Ireland, and Poland (men), and Ireland and England (women). Heavy drinking was associated with living away from home, having a wealthier family background, and having well-educated parents. Beliefs about the dangers to health of excessive consumption were negatively related to heavy drinking. Heavy drinking is a concern among students in several countries and is associated with greater affluence. Challenging beliefs concerning health risks is a crucial aspect of prevention in this population.


Assuntos
Consumo de Bebidas Alcoólicas/epidemiologia , Intoxicação Alcoólica/epidemiologia , Conhecimentos, Atitudes e Prática em Saúde , Estudantes/estatística & dados numéricos , Universidades , Adolescente , Adulto , Fatores Etários , Características Culturais , Feminino , Humanos , Masculino , Fatores Sexuais , Fatores Socioeconômicos , Estudantes/psicologia
9.
Clin Psychol Rev ; 23(6): 787-800, 2003 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-14529698

RESUMO

A critical examination of the recent literature on anxiety and depression in juvenile diabetes is presented. The objectives of this review are: (1) to determine the general association of psychological factors, especially anxiety and depression, with diabetes, (2) to examine the specific association of anxiety and depression with metabolic control, and (3) to propose methodological changes that are needed to advance future research in this field. The major conclusions of this review support the notion of a general association of psychological disorders with juvenile diabetes. However, while anxiety and depression appear to play an important and complex role in determining adaptation to the disease, their relationship to metabolic control does not yet appear clear. Additional prospective and controlled studies as well as multivariate models of chronic disease are now necessary to more fully understand the etiology and impact of these disorders in the adolescent population.


Assuntos
Transtornos de Ansiedade/psicologia , Transtorno Depressivo/psicologia , Diabetes Mellitus Tipo 1/psicologia , Adolescente , Adulto , Transtornos de Ansiedade/etiologia , Criança , Pré-Escolar , Transtorno Depressivo/etiologia , Diabetes Mellitus Tipo 1/complicações , Diabetes Mellitus Tipo 1/metabolismo , Humanos
10.
PLoS One ; 9(9): e105328, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-25207649

RESUMO

Crohn's disease (CD) and irritable bowel syndrome (IBS) involve brain-gut dysfunctions where vagus nerve is an important component. The aim of this work was to study the association between vagal tone and markers of stress and inflammation in patients with CD or IBS compared to healthy subjects (controls). The study was performed in 73 subjects (26 controls, 21 CD in remission and 26 IBS patients). The day prior to the experiment, salivary cortisol was measured at 8:00 AM and 10:00 PM. The day of the experiment, subjects completed questionnaires for anxiety (STAI) and depressive symptoms (CES-D). After 30 min of rest, ECG was recorded for heart rate variability (HRV) analysis. Plasma cortisol, epinephrine, norepinephrine, TNF-alpha and IL-6 were measured in blood samples taken at the end of ECG recording. Compared with controls, CD and IBS patients had higher scores of state-anxiety and depressive symptomatology. A subgroup classification based on HRV-normalized high frequency band (HFnu) as a marker of vagal tone, showed that control subjects with high vagal tone had significantly lower evening salivary cortisol levels than subjects with low vagal tone. Such an effect was not observed in CD and IBS patients. Moreover, an inverse association (r =  -0.48; p<0.05) was observed between the vagal tone and TNF-alpha level in CD patients exclusively. In contrast, in IBS patients, vagal tone was inversely correlated with plasma epinephrine (r =  -0.39; p<0.05). No relationship was observed between vagal tone and IL-6, norepinephrine or negative affects (anxiety and depressive symptomatology) in any group. In conclusion, these data argue for an imbalance between the hypothalamus-pituitary-adrenal axis and the vagal tone in CD and IBS patients. Furthermore, they highlight the specific homeostatic link between vagal tone and TNF-alpha in CD and epinephrine in IBS and argue for the relevance of vagus nerve reinforcement interventions in those diseases.


Assuntos
Doença de Crohn/fisiopatologia , Epinefrina/sangue , Hidrocortisona/metabolismo , Síndrome do Intestino Irritável/fisiopatologia , Fator de Necrose Tumoral alfa/sangue , Nervo Vago/fisiopatologia , Adolescente , Adulto , Estudos de Casos e Controles , Análise por Conglomerados , Doença de Crohn/sangue , Doença de Crohn/metabolismo , Feminino , Frequência Cardíaca , Humanos , Hidrocortisona/sangue , Interleucina-6/sangue , Síndrome do Intestino Irritável/sangue , Síndrome do Intestino Irritável/metabolismo , Masculino , Pessoa de Meia-Idade , Norepinefrina/sangue , Saliva/metabolismo , Adulto Jovem
11.
Psychoneuroendocrinology ; 35(5): 653-62, 2010 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-19910123

RESUMO

Psychological factors and the autonomic nervous system (ANS) are implicated in the pathogenesis of inflammatory bowel diseases (IBD) and irritable bowel syndrome (IBS). This study aimed to assess, firstly the way IBS and IBD patients cope with their pathology according to their affective adjustment and secondly the possible links between these affective adjustments and ANS reactivity. Patients with Crohn's disease (CD; n=26), ulcerative colitis (UC; n=22), or IBS (n=27) were recruited and compared to 21 healthy subjects based on psychological variables (trait- and state anxiety, depressive symptomatology, negative mood, perceived stress, coping, health locus of control) and sympatho-vagal balance through heart-rate variability monitored at rest. A principal component analysis, performed on all affective variables, isolated a leading factor labelled as "affective adjustment". In each disease, patients were distributed into positive and negative affective adjustment. In all the diseases, a positive affect was associated with problem-focused coping, and a negative affect with emotion-focused coping and external health locus of control. Results show that the sympatho-vagal balance varied according to the disease. In CD presenting positive affectivity, an adapted high sympathetic activity was observed. In UC, a parasympathetic blunt was observed in the presence of negative affectivity and an equilibrated sympatho-vagal balance in the presence of positive affectivity. In contrast, in IBS, an important dysautonomia (with high sympathetic and low parasympathetic tone) was constantly observed whatever the affective adjustment. In conclusion, this study suggests that the equilibrium of the ANS is differentially adapted according to the disease. This equilibrium is conjugated with positive affective and cognitive adjustment in IBD (CD and UC) but not in IBS.


Assuntos
Adaptação Psicológica , Colite Ulcerativa/fisiopatologia , Colite Ulcerativa/psicologia , Doença de Crohn/fisiopatologia , Doença de Crohn/psicologia , Frequência Cardíaca/fisiologia , Síndrome do Intestino Irritável/fisiopatologia , Síndrome do Intestino Irritável/psicologia , Disautonomias Primárias/fisiopatologia , Adulto , Afeto , Colite Ulcerativa/complicações , Doença de Crohn/complicações , Feminino , Humanos , Controle Interno-Externo , Síndrome do Intestino Irritável/complicações , Masculino , Disautonomias Primárias/complicações
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