Detalhe da pesquisa
1.
Optimization of ether and aniline based inhibitors of lactate dehydrogenase.
Bioorg Med Chem Lett
; 41: 127974, 2021 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33771585
2.
Crystal structure of interleukin-6 in complex with a modified nucleic acid ligand.
J Biol Chem
; 289(12): 8720-34, 2014 Mar 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-24415767
3.
Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets.
Proc Natl Acad Sci U S A
; 109(49): 19971-6, 2012 Dec 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-23139410
4.
Specific Btk inhibition suppresses B cell- and myeloid cell-mediated arthritis.
Nat Chem Biol
; 7(1): 41-50, 2011 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-21113169
5.
Leveraging structure determination with fragment screening for infectious disease drug targets: MECP synthase from Burkholderia pseudomallei.
J Struct Funct Genomics
; 12(2): 63-76, 2011 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-21359640
6.
An ensemble of structures of Burkholderia pseudomallei 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase.
Acta Crystallogr Sect F Struct Biol Cryst Commun
; 67(Pt 9): 1044-50, 2011 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21904048
7.
Probing conformational states of glutaryl-CoA dehydrogenase by fragment screening.
Acta Crystallogr Sect F Struct Biol Cryst Commun
; 67(Pt 9): 1060-9, 2011 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21904051
8.
Structure of PolC reveals unique DNA binding and fidelity determinants.
Proc Natl Acad Sci U S A
; 105(52): 20695-700, 2008 Dec 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-19106298
9.
Naegleria fowleri: Protein structures to facilitate drug discovery for the deadly, pathogenic free-living amoeba.
PLoS One
; 16(3): e0241738, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33760815
10.
Pyrazole-Based Lactate Dehydrogenase Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties.
J Med Chem
; 63(19): 10984-11011, 2020 10 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32902275
11.
Effects of impurities on membrane-protein crystallization in different systems.
Acta Crystallogr D Biol Crystallogr
; 65(Pt 10): 1062-73, 2009 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-19770503
12.
Structure and analysis of nucleoside diphosphate kinase from Borrelia burgdorferi prepared in a transition-state complex with ADP and vanadate moieties.
Acta Crystallogr F Struct Biol Commun
; 74(Pt 6): 373-384, 2018 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29870023
13.
The structure of the transition state of the heterodimeric topoisomerase I of Leishmania donovani as a vanadate complex with nicked DNA.
J Mol Biol
; 357(4): 1202-10, 2006 Apr 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-16487540
14.
Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH).
J Med Chem
; 60(22): 9184-9204, 2017 11 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-29120638
15.
The crystal structure of human tyrosyl-DNA phosphodiesterase, Tdp1.
Structure
; 10(2): 237-48, 2002 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-11839309
16.
Embracing proteins: structural themes in aptamer-protein complexes.
Curr Opin Struct Biol
; 36: 122-32, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26919170
17.
Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis.
PLoS One
; 11(8): e0160350, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27500735
18.
Correction: Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis.
PLoS One
; 11(9): e0163641, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27658298
19.
Insights into substrate binding and catalytic mechanism of human tyrosyl-DNA phosphodiesterase (Tdp1) from vanadate and tungstate-inhibited structures.
J Mol Biol
; 324(5): 917-32, 2002 Dec 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-12470949
20.
Crystal structure of a transition state mimic for Tdp1 assembled from vanadate, DNA, and a topoisomerase I-derived peptide.
Chem Biol
; 10(2): 139-47, 2003 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-12618186