Detalhe da pesquisa
1.
Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma.
Nature
; 567(7748): 341-346, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30842654
2.
Novel orexin receptor agonists based on arene- or pyridine-fused 1,3-dihydro-2H-imidazole-2-imines.
Bioorg Med Chem Lett
; 99: 129624, 2024 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38272190
3.
Evaluation of the efficacy of the hypocretin/orexin receptor agonists TAK-925 and ARN-776 in narcoleptic orexin/tTA; TetO-DTA mice.
J Sleep Res
; 32(4): e13839, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-36808670
4.
The structure of importin α and the nuclear localization peptide of ChREBP, and small compound inhibitors of ChREBP-importin α interactions.
Biochem J
; 477(17): 3253-3269, 2020 09 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-32776146
5.
A Medicinal Chemistry-Driven Approach Identified the Sterol Isomerase EBP as the Molecular Target of TASIN Colorectal Cancer Toxins.
J Am Chem Soc
; 142(13): 6128-6138, 2020 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32163279
6.
A convergent approach toward fidaxomicin: Syntheses of the fully glycosylated northern and southern fragments.
Tetrahedron
; 79(4)2020 Dec 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33191957
7.
Triazoles inhibit cholesterol export from lysosomes by binding to NPC1.
Proc Natl Acad Sci U S A
; 114(1): 89-94, 2017 01 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-27994139
8.
A biosynthetically inspired synthesis of (-)-berkelic acid and analogs.
Tetrahedron
; 74(9): 909-919, 2018 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29867257
9.
Metabolite Regulation of Nuclear Localization of Carbohydrate-response Element-binding Protein (ChREBP): ROLE OF AMP AS AN ALLOSTERIC INHIBITOR.
J Biol Chem
; 291(20): 10515-27, 2016 May 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-26984404
10.
Synthesis and evaluation of analogs of 5'-(((Z)-4-amino-2-butenyl)methylamino)-5'-deoxyadenosine (MDL 73811, or AbeAdo) - An inhibitor of S-adenosylmethionine decarboxylase with antitrypanosomal activity.
Bioorg Med Chem
; 25(20): 5433-5440, 2017 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28807574
11.
Rifamycin Biosynthetic Congeners: Isolation and Total Synthesis of Rifsaliniketal and Total Synthesis of Salinisporamycin and Saliniketals A and B.
J Am Chem Soc
; 138(22): 7130-42, 2016 06 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27232659
12.
Synthesis and structure-activity studies of the V-ATPase inhibitor saliphenylhalamide (SaliPhe) and simplified analogs.
Bioorg Med Chem Lett
; 25(20): 4393-8, 2015 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26372654
13.
Inhibition by cellular vacuolar ATPase impairs human papillomavirus uncoating and infection.
Antimicrob Agents Chemother
; 58(5): 2905-11, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-24614368
14.
Anticancer benzoxaboroles block pre-mRNA processing by directly inhibiting CPSF3.
Cell Chem Biol
; 31(1): 139-149.e14, 2024 01 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-37967558
15.
Discovery and Optimization of N-Arylated Tetracyclic Dicarboximides That Target Primary Glioma Stem-like Cells.
J Med Chem
; 2024 May 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38804887
16.
Obatoclax, saliphenylhalamide, and gemcitabine inhibit influenza a virus infection.
J Biol Chem
; 287(42): 35324-35332, 2012 Oct 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-22910914
17.
Lessons and revelations from biomimetic syntheses.
Nat Chem Biol
; 7(12): 865-75, 2011 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22086288
18.
A room temperature copper catalyzed N-selective arylation of ß-amino alcohols with iodoanilines and aryl iodides.
Tetrahedron
; 69(36): 7646-7652, 2013 Sep 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-24039306
19.
Structural insights for selective disruption of Beclin 1 binding to Bcl-2.
Commun Biol
; 6(1): 1080, 2023 10 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-37875561
20.
Selective and brain-penetrant lanosterol synthase inhibitors target glioma stem-like cells by inducing 24(S),25-epoxycholesterol production.
Cell Chem Biol
; 30(2): 214-229.e18, 2023 02 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-36758549