Detalhe da pesquisa
1.
hERG stereoselective modulation by mexiletine-derived ureas: Molecular docking study, synthesis, and biological evaluation.
Arch Pharm (Weinheim)
; 356(10): e2300116, 2023 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-37460390
2.
Microwave-Assisted Extraction of Bioactive Compounds from Lentil Wastes: Antioxidant Activity Evaluation and Metabolomic Characterization.
Molecules
; 27(21)2022 Nov 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36364300
3.
Densely Functionalized 2-Methylideneazetidines: Evaluation as Antibacterials.
Molecules
; 26(13)2021 Jun 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-34202191
4.
Insights into Structure-Activity Relationships of 3-Arylhydrazonoindolin-2-One Derivatives for Their Multitarget Activity on ß-Amyloid Aggregation and Neurotoxicity.
Molecules
; 23(7)2018 06 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-29949947
5.
Nitric oxide inhibits the mitochondrial carnitine/acylcarnitine carrier through reversible S-nitrosylation of cysteine 136.
Biochim Biophys Acta Bioenerg
; 1858(7): 475-482, 2017 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-28438511
6.
The mitochondrial carnitine/acylcarnitine carrier is regulated by hydrogen sulfide via interaction with C136 and C155.
Biochim Biophys Acta
; 1860(1 Pt A): 20-7, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26459002
7.
Nitro-substituted tetrahydroindolizines and homologs: Design, kinetics, and mechanism of α-glucosidase inhibition.
Bioorg Med Chem Lett
; 27(17): 3980-3986, 2017 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28781158
8.
Novel 6-alkyl-bridged 4-arylalkylpiperazin-1-yl derivatives of azepino[4,3-b]indol-1(2H)-one as potent BChE-selective inhibitors showing protective effects against neurodegenerative insults.
Eur J Med Chem
; 270: 116353, 2024 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38579622
9.
N-(Phenoxyalkyl)amides as MT(1) and MT(2) ligands: antioxidant properties and inhibition of Ca(2+)/CaM-dependent kinase II.
Bioorg Med Chem
; 21(4): 847-51, 2013 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23332368
10.
New Insights Regarding Hemin Inhibition of the Purified Rat Brain 2-Oxoglutarate Carrier and Relationships with Mitochondrial Dysfunction.
J Clin Med
; 11(24)2022 Dec 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-36556135
11.
The Interaction of Hemin, a Porphyrin Derivative, with the Purified Rat Brain 2-Oxoglutarate Carrier.
Biomolecules
; 11(8)2021 08 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34439841
12.
Synthesis and Evaluation of Voltage-Gated Sodium Channel Blocking Pyrroline Derivatives Endowed with Both Antiarrhythmic and Antioxidant Activities.
ChemMedChem
; 16(3): 578-588, 2021 02 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33015979
13.
New N-(phenoxydecyl)phthalimide derivatives displaying potent inhibition activity towards alpha-glucosidase.
Bioorg Med Chem
; 18(16): 5903-14, 2010 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20667739
14.
Scouting around 1,2,3,4-Tetrahydrochromeno[3,2-c]pyridin-10-ones for Single- and Multitarget Ligands Directed towards Relevant Alzheimer's Targets.
ChemMedChem
; 15(20): 1947-1955, 2020 10 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-32716595
15.
Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease.
Eur J Med Chem
; 177: 414-424, 2019 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31158754
16.
Discovery of Potent Dual Binding Site Acetylcholinesterase Inhibitors via Homo- and Heterodimerization of Coumarin-Based Moieties.
ChemMedChem
; 12(16): 1349-1358, 2017 08 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-28570763
17.
Mannich base approach to 5-methoxyisatin 3-(4-isopropylphenyl)hydrazone: A water-soluble prodrug for a multitarget inhibition of cholinesterases, beta-amyloid fibrillization and oligomer-induced cytotoxicity.
Eur J Pharm Sci
; 109: 381-388, 2017 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28801274
18.
Synthesis, antiarrhythmic activity, and toxicological evaluation of mexiletine analogues.
Eur J Med Chem
; 121: 300-307, 2016 Oct 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-27267000
19.
Synthesis and toxicopharmacological evaluation of m-hydroxymexiletine, the first metabolite of mexiletine more potent than the parent compound on voltage-gated sodium channels.
J Med Chem
; 55(3): 1418-22, 2012 Feb 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-22191686