RESUMO
This review examines the planning, development, and course of the first established colony for epilepsy in the United States-The Ohio Hospital for Epileptics. The events leading to the development of the colony, its early course, and the people who were instrumental in its establishment and maintenance are reviewed. At approximately the same time as the development of the Ohio Hospital for Epileptics, eugenics was gaining momentum in America, which affected epilepsy deeply. How this movement influenced thinking and practice at the Ohio Hospital is also reviewed.
Assuntos
Epilepsia/história , Hospitais/história , Epilepsia/etiologia , Epilepsia/genética , Epilepsia/terapia , História do Século XIX , História do Século XX , Humanos , Ohio , Estados UnidosRESUMO
We previously found increased microglial proliferation and pro-inflammatory cytokine release in infant mice compared to juvenile mice after hypoxia-ischemia (HI). The aim of the current study was to assess for differences in the effect of microglial suppression on HI-induced brain injury in infant and juvenile mice. HI was induced in neonatal (P9) and juvenile (P30) mice and minocycline or vehicle was administered at 2h and 24h post-HI. P9 minocycline-treated mice demonstrated early but transient improvements in neurologic injury, while P30 minocycline-treated mice demonstrated sustained improvements in cerebral atrophy and Morris Water Maze performance at 60days post-HI.