Detalhe da pesquisa
1.
Identification and in vitro characterization of a new series of potent and highly selective G9a inhibitors as novel anti-fibroadipogenic agents.
Bioorg Med Chem Lett
; 72: 128858, 2022 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35718104
2.
Discovery and antiviral profile of new sulfamoylbenzamide derivatives as HBV capsid assembly modulators.
Bioorg Med Chem Lett
; 73: 128904, 2022 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35868496
3.
Identification, biological characterization and pharmacophoric analysis of a new potent and selective NK1 receptor antagonist clinical candidate.
Bioorg Med Chem
; 21(21): 6264-73, 2013 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24075145
4.
Discovery of a Novel Series of Potent SHP2 Allosteric Inhibitors.
ACS Med Chem Lett
; 14(5): 645-651, 2023 May 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37197453
5.
Stereospecific synthesis and structure-activity relationships of unsymmetrical 4,4-diphenylbut-3-enyl derivatives of nipecotic acid as GAT-1 inhibitors.
Bioorg Med Chem Lett
; 21(1): 602-5, 2011 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21134748
6.
Discovery process and pharmacological characterization of a novel dual orexin 1 and orexin 2 receptor antagonist useful for treatment of sleep disorders.
Bioorg Med Chem Lett
; 21(18): 5562-7, 2011 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21831639
7.
1-Heteroaryl-6-(3,4-dichlorophenyl)-3-azabicyclo[4.1.0]heptane: further insights into a class of triple re-uptake inhibitors.
Bioorg Med Chem
; 19(11): 3451-61, 2011 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21550808
8.
Prdm16-mediated H3K9 methylation controls fibro-adipogenic progenitors identity during skeletal muscle repair.
Sci Adv
; 7(23)2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34078594
9.
2-Methyl-3-furanyl-4H-1,2,4-triazol-3-ylthioamides: a new class of selective orexin 2 antagonists.
Bioorg Med Chem Lett
; 20(22): 6405-7, 2010 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20933413
10.
[3-azabicyclo[3.1.0]hex-1-yl]phenyl-benzenesulfonamides as selective dopamine D3 antagonists.
Bioorg Med Chem Lett
; 20(18): 5491-4, 2010 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20692836
11.
Pyrrolo[1,2-a]pyrazine and pyrazolo[1,5-a]pyrazine: novel, potent, and selective series of Vasopressin 1b receptor antagonists.
Bioorg Med Chem Lett
; 20(17): 5044-9, 2010 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20674355
12.
Novel imidazobenzazepine derivatives as dual H1/5-HT2A antagonists for the treatment of sleep disorders.
Bioorg Med Chem Lett
; 20(17): 5069-73, 2010 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20674357
13.
Synthesis and pharmacological characterization of constrained analogues of Vestipitant as in vitro potent and orally active NK(1) receptor antagonists.
Bioorg Med Chem Lett
; 20(2): 623-7, 2010 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19963378
14.
Synthesis and structure-activity relationship of N-(3-azabicyclo[3.1.0]hex-6-ylmethyl)-5-(2-pyridinyl)-1,3-thiazol-2-amines derivatives as NPY Y5 antagonists.
Bioorg Med Chem Lett
; 20(16): 4741-4, 2010 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20630754
15.
Design, synthesis and SAR of a novel series of benzimidazoles as potent NPY Y5 antagonists.
Bioorg Med Chem Lett
; 20(23): 7120-3, 2010 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20951033
16.
Synthesis and pharmacological characterization of 5-phenyl-2-[2-(1-piperidinylcarbonyl)phenyl]-2,3-dihydro-1H-pyrrolo[1,2-c]imidazol-1-ones: a new class of Neuropeptide S antagonists.
Bioorg Med Chem Lett
; 20(24): 7308-11, 2010 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21055936
17.
Discovery and structure-activity relationship of a novel spirocarbamate series of NPY Y5 antagonists.
Bioorg Med Chem Lett
; 20(20): 6103-7, 2010 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20813523
18.
Discovery of NBI-77860/GSK561679, a potent corticotropin-releasing factor (CRF1) receptor antagonist with improved pharmacokinetic properties.
Bioorg Med Chem Lett
; 20(24): 7259-64, 2010 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21074436
19.
5-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}-2(1H)-quinolinones and 3,4-dihydro-2(1H)-quinolinones: dual-acting 5-HT1 receptor antagonists and serotonin reuptake inhibitors. Part 3.
Bioorg Med Chem Lett
; 20(23): 7092-6, 2010 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20951584
20.
The identification of a selective dopamine D2 partial agonist, D3 antagonist displaying high levels of brain exposure.
Bioorg Med Chem Lett
; 20(6): 2013-6, 2010 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20153647