Detalhe da pesquisa
1.
A Cryptosporidium PI(4)K inhibitor is a drug candidate for cryptosporidiosis.
Nature
; 546(7658): 376-380, 2017 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28562588
2.
Transcriptional profiling of hepatocytes infected with the replicative form of the malaria parasite Plasmodium cynomolgi.
Malar J
; 21(1): 393, 2022 Dec 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36564750
3.
Antimalarial Activity of KAF156 in Falciparum and Vivax Malaria.
N Engl J Med
; 375(12): 1152-60, 2016 09 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-27653565
4.
Targeting Plasmodium PI(4)K to eliminate malaria.
Nature
; 504(7479): 248-253, 2013 Dec 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-24284631
5.
Imidazolopiperazines Kill both Rings and Dormant Rings in Wild-Type and K13 Artemisinin-Resistant Plasmodium falciparum In Vitro.
Antimicrob Agents Chemother
; 62(5)2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29530849
6.
Spiroindolone KAE609 for falciparum and vivax malaria.
N Engl J Med
; 371(5): 403-10, 2014 Jul 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-25075833
7.
The Spiroindolone KAE609 Does Not Induce Dormant Ring Stages in Plasmodium falciparum Parasites.
Antimicrob Agents Chemother
; 60(9): 5167-74, 2016 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27297484
8.
PI4 Kinase Is a Prophylactic but Not Radical Curative Target in Plasmodium vivax-Type Malaria Parasites.
Antimicrob Agents Chemother
; 60(5): 2858-63, 2016 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-26926645
9.
Pharmacokinetic-pharmacodynamic analysis of spiroindolone analogs and KAE609 in a murine malaria model.
Antimicrob Agents Chemother
; 59(2): 1200-10, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25487807
10.
Targeting the ERAD pathway via inhibition of signal peptide peptidase for antiparasitic therapeutic design.
Proc Natl Acad Sci U S A
; 109(52): 21486-91, 2012 Dec 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-23236186
11.
A first-in-human randomized, double-blind, placebo-controlled, single- and multiple-ascending oral dose study of novel antimalarial Spiroindolone KAE609 (Cipargamin) to assess its safety, tolerability, and pharmacokinetics in healthy adult volunteers.
Antimicrob Agents Chemother
; 58(10): 6209-14, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-25114127
12.
A first-in-human randomized, double-blind, placebo-controlled, single- and multiple-ascending oral dose study of novel Imidazolopiperazine KAF156 to assess its safety, tolerability, and pharmacokinetics in healthy adult volunteers.
Antimicrob Agents Chemother
; 58(11): 6437-43, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-25136017
13.
KAI407, a potent non-8-aminoquinoline compound that kills Plasmodium cynomolgi early dormant liver stage parasites in vitro.
Antimicrob Agents Chemother
; 58(3): 1586-95, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24366744
14.
KAF156 is an antimalarial clinical candidate with potential for use in prophylaxis, treatment, and prevention of disease transmission.
Antimicrob Agents Chemother
; 58(9): 5060-7, 2014 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-24913172
15.
Progressing the global antimalarial portfolio: finding drugs which target multiple Plasmodium life stages.
Parasitology
; 141(1): 66-76, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-23746048
16.
Drug discovery for parasitic diseases: powered by technology, enabled by pharmacology, informed by clinical science.
Trends Parasitol
; 39(4): 260-271, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36803572
17.
A conserved metabolic signature associated with response to fast-acting anti-malarial agents.
Microbiol Spectr
; 11(6): e0397622, 2023 Dec 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37800971
18.
Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections.
Science
; 380(6652): 1349-1356, 2023 06 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-37384702
19.
Discovery of Novel Quinoline-Based Proteasome Inhibitors for Human African Trypanosomiasis (HAT).
J Med Chem
; 65(17): 11776-11787, 2022 09 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35993839
20.
Discovery and Preclinical Pharmacology of INE963, a Potent and Fast-Acting Blood-Stage Antimalarial with a High Barrier to Resistance and Potential for Single-Dose Cures in Uncomplicated Malaria.
J Med Chem
; 65(5): 3798-3813, 2022 03 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35229610