Detalhe da pesquisa
1.
Development of a Selective and High Affinity Radioligand, [3H]VU6013720, for the M4 Muscarinic Receptor.
Mol Pharmacol
; 104(5): 195-202, 2023 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-37595966
2.
Synthesis and characterization of chiral 6-azaspiro[2.5]octanes as potent and selective antagonists of the M4 muscarinic acetylcholine receptor.
Bioorg Med Chem Lett
; 56: 128479, 2022 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34838649
3.
Discovery and optimization of a novel CNS penetrant series of mGlu4 PAMs based on a 1,4-thiazepane core with in vivo efficacy in a preclinical Parkinsonian model.
Bioorg Med Chem Lett
; 37: 127838, 2021 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33556572
4.
Optimization of the choline transporter (CHT) inhibitor ML352: Development of VU6001221, an improved in vivo tool compound.
Bioorg Med Chem Lett
; 26(19): 4637-4640, 2016 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27575469
5.
Development of a Peripherally Restricted 5-HT2B Partial Agonist for Treatment of Pulmonary Arterial Hypertension.
JACC Basic Transl Sci
; 8(10): 1379-1388, 2023 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-38094686
6.
Preserved vascular integrity and enhanced survival following neuropilin-1 inhibition in a mouse model of CD8 T cell-initiated CNS vascular permeability.
J Neuroinflammation
; 9: 218, 2012 Sep 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-22985494
7.
The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's disease.
J Pharmacol Exp Ther
; 340(2): 404-21, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22088953
8.
CD8 T cell-initiated vascular endothelial growth factor expression promotes central nervous system vascular permeability under neuroinflammatory conditions.
J Immunol
; 184(2): 1031-40, 2010 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20008293
9.
Discovery of "Molecular Switches" within a Series of mGlu5 Allosteric Ligands Driven by a "Magic Methyl" Effect Affording Both PAMs and NAMs with In Vivo Activity, Derived from an M1 PAM Chemotype.
ACS Bio Med Chem Au
; 1(1): 21-30, 2021 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37101980
10.
Discovery of VU6028418: A Highly Selective and Orally Bioavailable M4 Muscarinic Acetylcholine Receptor Antagonist.
ACS Med Chem Lett
; 12(8): 1342-1349, 2021 Aug 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34413964
11.
Discovery of the First Selective M4 Muscarinic Acetylcholine Receptor Antagonists with in Vivo Antiparkinsonian and Antidystonic Efficacy.
ACS Pharmacol Transl Sci
; 4(4): 1306-1321, 2021 Aug 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-34423268
12.
Discovery of Tricyclic Triazolo- and Imidazopyridine Lactams as M1 Positive Allosteric Modulators.
ACS Chem Neurosci
; 10(3): 1035-1042, 2019 03 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-30086237
13.
VU6007477, a Novel M1 PAM Based on a Pyrrolo[2,3-b]pyridine Carboxamide Core Devoid of Cholinergic Adverse Events.
ACS Med Chem Lett
; 9(9): 917-922, 2018 Sep 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30258541
14.
M1-positive allosteric modulators lacking agonist activity provide the optimal profile for enhancing cognition.
Neuropsychopharmacology
; 43(8): 1763-1771, 2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29581537
15.
A Novel M1 PAM VU0486846 Exerts Efficacy in Cognition Models without Displaying Agonist Activity or Cholinergic Toxicity.
ACS Chem Neurosci
; 9(9): 2274-2285, 2018 09 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-29701957
16.
M1 muscarinic activation induces long-lasting increase in intrinsic excitability of striatal projection neurons.
Neuropharmacology
; 118: 209-222, 2017 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28336323
17.
Role of mGlu5 Receptors and Inhibitory Neurotransmission in M1 Dependent Muscarinic LTD in the Prefrontal Cortex: Implications in Schizophrenia.
ACS Chem Neurosci
; 8(10): 2254-2265, 2017 10 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-28679049
18.
Co-Activation of Metabotropic Glutamate Receptor 3 and Beta-Adrenergic Receptors Modulates Cyclic-AMP and Long-Term Potentiation, and Disrupts Memory Reconsolidation.
Neuropsychopharmacology
; 42(13): 2553-2566, 2017 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-28664928
19.
Diverse Effects on M1 Signaling and Adverse Effect Liability within a Series of M1 Ago-PAMs.
ACS Chem Neurosci
; 8(4): 866-883, 2017 04 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-28001356
20.
Biased mGlu5-Positive Allosteric Modulators Provide In Vivo Efficacy without Potentiating mGlu5 Modulation of NMDAR Currents.
Neuron
; 86(4): 1029-1040, 2015 May 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-25937172