Detalhe da pesquisa
1.
Prediction of Transporter-Mediated Drug-Drug Interactions and Phenotyping of Hepatobiliary Transporters Involved in the Clearance of E7766, a Novel Macrocycle-Bridged Dinucleotide.
Drug Metab Dispos
; 49(3): 265-275, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33355210
2.
First-in-human study of the PARP/tankyrase inhibitor E7449 in patients with advanced solid tumours and evaluation of a novel drug-response predictor.
Br J Cancer
; 123(4): 525-533, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32523090
3.
B-cell repertoire responses to varicella-zoster vaccination in human identical twins.
Proc Natl Acad Sci U S A
; 112(2): 500-5, 2015 Jan 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-25535378
4.
Single B-cell deconvolution of peanut-specific antibody responses in allergic patients.
J Allergy Clin Immunol
; 137(1): 157-167, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26152318
5.
Application of Micropatterned Cocultured Hepatocytes to Evaluate the Inductive Potential and Degradation Rate of Major Xenobiotic Metabolizing Enzymes.
Drug Metab Dispos
; 44(2): 250-61, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26658225
6.
Polyproline fold-In imparting kinetic stability to an alkaline serine endopeptidase.
Biochim Biophys Acta
; 1834(3): 708-16, 2013 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-23270996
7.
Pharmacologic Activation of STING in the Bladder Induces Potent Antitumor Immunity in Non-Muscle Invasive Murine Bladder Cancer.
Mol Cancer Ther
; 21(6): 914-924, 2022 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35313332
8.
Complex drug interactions of HIV protease inhibitors 2: in vivo induction and in vitro to in vivo correlation of induction of cytochrome P450 1A2, 2B6, and 2C9 by ritonavir or nelfinavir.
Drug Metab Dispos
; 39(12): 2329-37, 2011 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-21930825
9.
Physiologically-Based Pharmacokinetic Modeling in Renal and Hepatic Impairment Populations: A Pharmaceutical Industry Perspective.
Clin Pharmacol Ther
; 110(2): 297-310, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33270249
10.
A comparison of the roles of peroxisome proliferator-activated receptor and retinoic acid receptor on CYP26 regulation.
Mol Pharmacol
; 77(2): 218-27, 2010 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-19884280
11.
Physiologically-Based Pharmacokinetic Models for Evaluating Membrane Transporter Mediated Drug-Drug Interactions: Current Capabilities, Case Studies, Future Opportunities, and Recommendations.
Clin Pharmacol Ther
; 107(5): 1082-1115, 2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31628859
12.
Age-dependent kinetics and metabolism of dichloroacetate: possible relevance to toxicity.
J Pharmacol Exp Ther
; 324(3): 1163-71, 2008 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-18096758
13.
Celecoxib is a substrate of CYP2D6: Impact on celecoxib metabolism in individuals with CYP2C9*3 variants.
Drug Metab Pharmacokinet
; 33(5): 219-227, 2018 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-30219715
14.
Correction: Pharmacologic Activation of STING in the Bladder Induces Potent Antitumor Immunity in Non-Muscle Invasive Murine Bladder Cancer.
Mol Cancer Ther
; 22(4): 551, 2023 Apr 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-37009707
15.
Discovery and Characterization of a Water-Soluble Prodrug of a Dual Inhibitor of Bacterial DNA Gyrase and Topoisomerase IV.
ACS Med Chem Lett
; 6(7): 822-6, 2015 Jul 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-26191374
16.
Second-generation antibacterial benzimidazole ureas: discovery of a preclinical candidate with reduced metabolic liability.
J Med Chem
; 57(21): 8792-816, 2014 Nov 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-25317480
17.
Convergent antibody signatures in human dengue.
Cell Host Microbe
; 13(6): 691-700, 2013 Jun 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-23768493
18.
Expression and functional characterization of cytochrome P450 26A1, a retinoic acid hydroxylase.
Biochem Pharmacol
; 77(2): 258-68, 2009 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18992717
19.
In vitro LC-MS cocktail assays to simultaneously determine human cytochrome P450 activities.
Biopharm Drug Dispos
; 28(5): 257-62, 2007 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-17443647
20.
Cytochrome P450 enzymes and transporters induced by anti-human immunodeficiency virus protease inhibitors in human hepatocytes: implications for predicting clinical drug interactions.
Drug Metab Dispos
; 35(10): 1853-9, 2007 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-17639026