Detalhe da pesquisa
1.
Synthesis and evaluation of carbamoylmethylene linked prodrugs of BMS-582949, a clinical p38α inhibitor.
Bioorg Med Chem Lett
; 23(10): 3028-33, 2013 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23578688
2.
Synthesis and structure-activity relationships of novel indazolyl glucocorticoid receptor partial agonists.
Bioorg Med Chem Lett
; 23(19): 5448-51, 2013 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23916594
3.
The identification of novel p38α isoform selective kinase inhibitors having an unprecedented p38α binding mode.
Bioorg Med Chem Lett
; 23(14): 4120-6, 2013 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23746475
4.
Discovery of potent and selective nonsteroidal indazolyl amide glucocorticoid receptor agonists.
Bioorg Med Chem Lett
; 23(19): 5442-7, 2013 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23953070
5.
A novel oral formulation of the melanocortin-1 receptor agonist PL8177 resolves inflammation in preclinical studies of inflammatory bowel disease and is gut restricted in rats, dogs, and humans.
Front Immunol
; 14: 1083333, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36891301
6.
Efficacy and Safety of the Melanocortin Pan-Agonist PL9643 in a Phase 2 Study of Patients with Dry Eye Disease.
J Ocul Pharmacol Ther
; 39(9): 600-610, 2023 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37677000
7.
Pro-resolving and anti-arthritic properties of the MC1 selective agonist PL8177.
Front Immunol
; 13: 1078678, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36505403
8.
Discovery of pyrrolo[2,1-f][1,2,4]triazine C6-ketones as potent, orally active p38α MAP kinase inhibitors.
Bioorg Med Chem Lett
; 21(15): 4633-7, 2011 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21705217
9.
Imidazo[4,5-d]thiazolo[5,4-b]pyridine based inhibitors of IKK2: synthesis, SAR, PK/PD and activity in a preclinical model of rheumatoid arthritis.
Bioorg Med Chem Lett
; 21(1): 383-6, 2011 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21087862
10.
Novel tricyclic inhibitors of IKK2: discovery and SAR leading to the identification of 2-methoxy-N-((6-(1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl)pyridin-2-yl)methyl)acetamide (BMS-066).
Bioorg Med Chem Lett
; 21(23): 7006-12, 2011 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22018461
11.
Pharmacokinetics of the Melanocortin Type 1 Receptor Agonist PL8177 After Subcutaneous Administration.
Drugs R D
; 21(4): 431-443, 2021 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-34693509
12.
Utilization of a nitrogen-sulfur nonbonding interaction in the design of new 2-aminothiazol-5-yl-pyrimidines as p38α MAP kinase inhibitors.
Bioorg Med Chem Lett
; 20(19): 5864-8, 2010 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20732813
13.
5-amino-pyrazoles as potent and selective p38α inhibitors.
Bioorg Med Chem Lett
; 20(23): 6886-9, 2010 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21035336
14.
Identification of potent pyrimidine inhibitors of phosphodiesterase 7 (PDE7) and their ability to inhibit T cell proliferation.
Bioorg Med Chem Lett
; 19(7): 1935-8, 2009 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19272774
15.
Synthesis, initial SAR and biological evaluation of 1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-4-amine derived inhibitors of IkappaB kinase.
Bioorg Med Chem Lett
; 19(10): 2646-9, 2009 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19376699
16.
Design, synthesis, and anti-inflammatory properties of orally active 4-(phenylamino)-pyrrolo[2,1-f][1,2,4]triazine p38alpha mitogen-activated protein kinase inhibitors.
J Med Chem
; 51(1): 4-16, 2008 Jan 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-18072718
17.
Benzothiazole based inhibitors of p38alpha MAP kinase.
Bioorg Med Chem Lett
; 18(6): 1874-9, 2008 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18296051
18.
Pyrazolo-pyrimidines: a novel heterocyclic scaffold for potent and selective p38 alpha inhibitors.
Bioorg Med Chem Lett
; 18(8): 2652-7, 2008 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18359226
19.
Synthesis and SAR of new pyrrolo[2,1-f][1,2,4]triazines as potent p38 alpha MAP kinase inhibitors.
Bioorg Med Chem Lett
; 18(8): 2739-44, 2008 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18364256
20.
The discovery of (R)-2-(sec-butylamino)-N-(2-methyl-5-(methylcarbamoyl)phenyl) thiazole-5-carboxamide (BMS-640994)-A potent and efficacious p38alpha MAP kinase inhibitor.
Bioorg Med Chem Lett
; 18(6): 1762-7, 2008 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18313298