Direct generation of a 635 nm red random laser based on praseodymium (Pr)-doped ZBLAN fiber.

Visible random fiber lasers have garnered significant attention due to their unique emission properties and potential applications in various fields. We first, to the best of our knowledge, demonstrated a compact all-fiber structure, red wavelength, and random fiber laser (RFL) based on a double-clad Pr-doped ZBLAN fiber. The simple half-open cavity consists of a high-reflectivity fiber pigtail mirror and the Pr-doped ZBLAN fiber. The Pr-doped ZBLAN fiber not only served as a gain medium but also offered random backward scattering. We investigated the effects of different lengths on output power and slope efficiency of the RFL. For 21 m Pr-doped fiber, the RFL emitted a maximum output power of 208.50 mW with a slope efficiency of 11.09%. For 15 m Pr-doped fiber, the maximum power decreased to 120.18 mW with the slope efficiency of 7.27%. We are also numerically simulating the output power versus the pump power at different fiber lengths based on power steady-state light propagation equations. This novel RFL has the potential for broad applications in fields such as display technology, spectroscopy, biomedical imaging, and optical sensing due to its unique properties and simple all-fiber structure.

1283-1460 nm continuously tunable, watt-level bismuth-doped phosphosilicate fiber laser and its frequency doubling to a visible laser.

We report, to the best of our knowledge, the first demonstration of an O + E-band tunable watt-level bismuth-doped phosphosilicate fiber laser and its frequency doubling to tunable red laser. Benefiting from the two types of bismuth active centers associated with silicon and phosphorus introduced in one fiber, an ultrabroad gain is available in the designed low-water-peak bismuth-doped phosphosilicate fiber (Bi-PSF) pumped by a self-made 1239 nm Raman fiber laser. The high-efficiency tunable lasing is achieved with a maximum output power of 1.705 W around 1320 nm and a slope efficiency of 33.0%. The wavelength can be continuously tuned from 1283 to 1460 nm over a 177 nm spectral range, almost covering the whole O+E-bands. We further employ a polarization beam splitter in the cavity to output an O + E-band linear-polarization laser for second-harmonic generation by a designed multi-period MgO2:PPLN crystal, and a 650-690-nm tunable visible laser is correspondingly obtained. Such an O+E-wideband tunable high-power laser and the SHG red laser may have great potential in the all-band optical communications, biophotonics, and spectroscopy.

An optimized denoising method for ICESat-2 photon-counting data considering heterogeneous density and weak connectivity.

The Ice, Cloud, and Land Elevation Satellite-2 (ICESat-2) can obtain underwater elevation due to its strong penetration ability. However, the photons recorded by ICESat-2 include a large amount of noise that needs to be removed. Although density-based clustering methods can finish signal photon extraction, heterogeneous density and weak connectivity in photon data distribution impede their denoising performance, especially for sparse signals in deep water and drastic topographic change areas. In this paper, a novel fused denoising method based on the local outlier factor and inverse distance metric is proposed to overcome the above problems. The local outlier factor and inverse distance metric are calculated based on K-nearest neighbors (KNNs), taking into account not only the difference in density but also the directional uniformity of the data distribution. Using six trajectories under various seabed topographies, the proposed method is compared with state-of-the-art ICESat-2 photon denoising algorithms and official ATL03 results. The results indicate that the overall accuracy of the proposed method can surpass 96%, and the proposed method maintains higher recall but also has a lower false positive rate. Compared with the results of other methods, the proposed method can better adopt areas with abrupt topographic changes and deep water. The extracted signal strips are more unbroken and continuous. This study can contribute to pioneering a new perspective for ICESat-2 photon-counting data denoising research that is limited to using only density-based algorithms.

1.3/1.4 µm dual-wave band dissipative soliton resonance in a passively mode-locked Bi-doped phosphosilicate fiber laser.

We report the 1.3/1.4 µm dual-wave band dissipative soliton resonance (DSR) in a passively mode-locked bismuth-doped phosphosilicate fiber (Bi-PSF) laser. The low-water-peak Bi-PSF with two bismuth active centers associated with silicon and phosphorus supports the O+E-band gain. Using a 1239 nm home-made Raman fiber laser as pump source and nonlinear amplifying loop mirror for initiating mode-locking, stable DSR operation at 1343 and 1406 nm is achieved with the spectral bandwidth of 12 and 16 nm. The pulse duration with the pump power increases from 62 to 270 ps with a repetition frequency of 4.069 MHz. The average power is 11.05 mW corresponding to the maximum energy of 2.7 nJ. This is, to the best of our knowledge, the first demonstration of a mode-locked fiber laser in the ∼1.38 µm water absorption band and the O+E dual-wave band operation for applications in all-spectral-band communications, bio-medical imaging, and terahertz difference frequency generation.

Satellite-derived bathymetry integrating spatial and spectral information of multispectral images.

As a significant and cost-effective method of obtaining shallow seabed topography, satellite derived bathymetry (SDB) can acquire a wide range of shallow sea depth by integrating a small quantity of in-situ water depth data. This method is a beneficial addition to traditional bathymetric topography. The seafloor's spatial heterogeneity leads to inaccuracies in bathymetric inversion, which reduces bathymetric accuracy. By utilizing multispectral data with multidimensional features, an SDB approach incorporating spectral and spatial information of multispectral images is proposed in this study. In order to effectively increase the accuracy of bathymetry inversion throughout the entire area, first the random forest with spatial coordinates is established to control bathymetry spatial variation on a large scale. Next, the Kriging algorithm is used to interpolate bathymetry residuals, and the interpolation results are used to adjust bathymetry spatial variation on a small scale. The data from three shallow water sites are experimentally processed to validate the method. Compared with other established bathymetric inversion techniques, the experimental results show that the method effectively reduces the error in bathymetry estimation caused by spatial heterogeneity of the seabed, producing high-precision inversion bathymetry with a root mean square error of 0.78 to 1.36 meters.

Potential application of a green fiber laser in laser display systems.

This study explores the application of optical fiber lasers in display systems by integrating a P r3+-doped green all-fiber laser into a laser projection display system. As a control group to compare the results, a 520 nm semiconductor green laser diode module was integrated, similar to the experimental group. The color gamut and speckle performances were studied and compared. The results showed that the experimental group performed slightly better in the color gamut volume. The speckle contrast decreased rapidly in the experimental group when power increased. To our knowledge, this is the first study to apply a fiber laser to a laser display system. The results shed light on developing laser display systems with fewer or no speckle reduction elements.

Point-of-Care and Dual-Response Detection of Hydrazine/Hypochlorite-Based on a Smart Hydrogel Sensor and Applications in Information Security and Bioimaging.

A novel dual-response fluorescence probe (XBT-CN) was developed by using a fluorescence priming strategy for quantitative monitoring and visualization of hydrazine (N2H4) and hypochlorite (ClO-). With the addition of N2H4/ClO-, the cleavage reaction of C=C bond initiated by N2H4/ClO- was transformed into corresponding hydrazone and aldehyde derivatives, inducing the probe XBT-CN appeared a fluorescence "off-on" response, which was verified by DFT calculation. HRMS spectra were also conducted to confirm the sensitive mechanism of XBT-CN to N2H4 and ClO-. The probe XBT-CN had an obvious fluorescence response to N2H4 and ClO-, which caused a significant color change in unprotected eyes. In addition, the detection limits of XBT-CN for N2H4 and ClO- were 27 nM and 34 nM, respectively. Interference tests showed that other competitive analytes could hardly interfere with the detection of N2H4 and ClO- in a complex environment. In order to realize the point-of-care detection of N2H4 and ClO-, an XBT-CN@hydrogel test kit combined with a portable smartphone was developed. Furthermore, the portable test kit has been applied to the detection of N2H4 and ClO- in a real-world environment and food samples, and a series of good results have been achieved. Attractively, we demonstrated that XBT-CN@hydrogel was successfully applied as an encryption ink in the field of information security. Finally, the probe can also be used to monitor and distinguish N2H4 and ClO- in living cells, exhibiting excellent biocompatibility and low cytotoxicity.

On-chip mid-IR octave-tunable Raman soliton laser.

Photonic chip-based continuously tunable lasers are widely recognized as an indispensable component for photonic integrated circuits (PICs). Specifically, mid-infrared (mid-IR) laser sources are of paramount importance in applications such as photonic sensing and spectroscopy. In this article, we theoretically investigate the propagation dynamics of mid-IR Raman soliton in Ge28Sb12Se60 chalcogenide glass waveguide. By carefully engineer the waveguide dispersion and nonlinear interaction, we propose a suspended chalcogenide glass waveguide device that allows an octave-tuning, from 1.96 µm to 3.98 µm, Raman soliton source. The threshold pump energy is in the low pico-Joule range. Our result provides a solution to continuously tunable on-chip mid-IR ultrafast laser sources.

High-power cylindrical vector beam fiber laser based on an all-polarization-maintaining structure.

We propose and demonstrate an all-polarization-maintaining (PM) high-power cylindrical vector beam (CVB) fiber laser based on the principle of mode superposition. The non-degenerated LPy 11a is generated from the oscillator with the maximum power of 11.9W, whose slope efficiency is 24.4%. Then the stable single TE01 vector beam is achieved by the superposition of LPy 11a and LPx 11b in an all-PM architecture, its output power is 3.1W and mode purity of 91.2%. Due to the all-PM architecture, our configuration is free of adjusting polarization controller (PC) and reliable during long-term operation. This laser could be used as a high-power CVBs source for a wide range of applications towards scientific research and industrial field.

ICESat-2 laser data denoising algorithm based on a back propagation neural network.

The Ice, Cloud, and Land Elevation Satellite-2 (ICESat-2) photon data is the emerging satellite-based LiDAR data, widely used in surveying and mapping due to its small photometric spot and high density. Since ICESat-2 data collect weak signals, it is difficult to denoise in shallow sea island areas, and the quality of the denoising method will directly affect the precision of bathymetry. This paper proposes a back propagation (BP) neural network-based denoising algorithm for the data characteristics of shallow island reef areas. First, a horizontal elliptical search area is constructed for the photons in the dataset. Suitable feature values are selected in the search area to train the BP neural network. Finally, data with a geographic location far apart, including daily and nightly data, are selected respectively for experiments to test the generality of the network. By comparing the results with the confidence labels provided in the official documents of the ATL03 dataset, the DBSCAN algorithm, and the manual visual interpretation, it is proved that the denoising algorithm proposed in this paper has a better processing effect in shallow island areas.

An FGFR1-Binding Peptide Modified Liposome for siRNA Delivery in Lung Cancer.

Liposome modification by targeting ligands has been used to mediate specific interactions and drug delivery to target cells. In this study, a new peptide ligand, CP7, was found to be able to effectively bind to FGFR1 through reverse molecular docking and could cooperate with VEGFR3 to achieve targeting of A549 cells. CP7 was modified on the surface of the liposome to construct a targeted and safe nanovehicle for the delivery of a therapeutic gene, Mcl-1 siRNA. Due to the specific binding between CP7 and A549 cells, siRNA-loaded liposome-PEG-CP7 showed increased cellular uptake in vitro, resulting in significant apoptosis of tumor cells through silencing of the Mcl-1 gene, which is associated with apoptosis and angiogenesis. This gene delivery system also showed significantly better antitumor activity in tumor-bearing mice in vivo. All of these suggested that siRNA-loaded liposome-PEG-CP7 could be a promising gene drug delivery system with good bioavailability and minimal side effects for treatment.

An Integrated Tumor Microenvironment Responsive Polymeric Micelle for Smart Drug Delivery and Effective Drug Release.

Tumor microenvironment (TME) responsive polymeric micelles are promising carriers for drug delivery. In order to meet the needs of various applications, multifarious TME-responsive switches are used to construct smart polymeric micelles, which causes the complexity and corpulence of the polymeric micelle system and increases the difficulty of preparation. In this study, we designed and synthesized an ingenious TME-responsive switch through grafting disulfide bond-modified piperidinepropionic acid (CPA) on copolymer poly(ethylene glycol)-b-poly(aspartate)(PEG-b-PAsp) and built a novel pH/reduction-responsive PEG-b-PAsp-g-CPA polymeric micelle delivery system. The CPA-pendants can reverse the surface charge of the polymeric micelle from negative to positive at pH 6.5 because of the protonation of piperidine groups, thereby enhancing the internalization of cell. Subsequently, more piperidine groups are protonated at pH 5.0 which will increase the hydrophilicity of polymeric micelles and cause the hydrophobic core to swell, thus making the disulfide bonds packed in the core to be more easily broken by GSH. With the synergistic effect of the pH-triggered protonation of piperidine groups and reduction triggered break of disulfide bonds, the polymeric micelles will disintegrate and achieve efficient intracellular drug release. The TME-responsive polymeric micelles exhibited good biological safety, enhanced internalization, and rapid intracellular doxorubicin (DOX) release in vitro. Moreover, the PEG-b-PAsp-g-CPA/DOX polymeric micelles showed excellent antitumor efficacy and low systemic toxicity in lung tumor-bearing BALB/C mice. These results indicated that the novel integrated TME-responsive switch CPA helps the PEG-b-PAsp-g-CPA polymeric micelles to obtain excellent TME-responsiveness and antitumor drug delivery capabilities, while it also makes the preparation of TME-responsive polymeric micelles simpler and more convenient. This work provides a new idea for the architecture of TME-responsive polymeric micelles.

Co-administration of combretastatin A4 nanoparticles and anti-PD-L1 for synergistic therapy of hepatocellular carcinoma.

BACKGROUND: According to data estimated by the WHO, primary liver cancer is currently the fourth most common malignant tumor and the second leading cause of death around the world. Hepatocellular carcinoma (HCC) is one of the most common primary liver malignancies, so effective therapy is highly desired for HCC. RESULTS: In this study, the use of poly(L-Aspartic acid)-poly(ethylene glycol)/combretastatin A4 (CA4-NPs) was aimed to significantly disrupt new blood vessels in tumor tissues for targeted hepatic tumor therapy. Here, PEG-b-PAsp-g-CA4 showed significantly prolonged retention in plasma and tumor tissue. Most importantly, CA4-NPs were mainly distributed at the tumor site because of the triple target effects-enhanced permeability and retention (EPR) effect, acid-sensitive (pH = 5.5) effect to the tumor microenvironment (TME), and good selectivity of CA4 for central tumor blood vessel. Considering that CA4-NPs might induce severe hypoxic conditions resulting in high expression of HIF-1α in tumor tissues, which could induce the overexpression of PD-L1, herein we also used a programmed death-ligand 1 antibody (aPD-L1) to prevent immunosuppression. This way of complementary combination is able to achieve an ideal treatment effect in tumor site where CA4-NPs and aPD-L1 could respond to the inner area and peripheral area, respectively. As a result, a significant decrease in tumor volume and weight was observed in the combination group of CA4-NPs plus aPD-L1 compared with CA4-NPs or aPD-L1 monotherapy in subcutaneous Hepa1-6 hepatic tumor models. CONCLUSIONS: We presented a new idea that co-administration of CA4-NPs and aPD-L1 possessed notable anti-tumor efficacy for HCC treatment.

Generation of stable orbital angular momentum beams with an all-polarization-maintaining fiber structure.

In this paper, we propose a stable orbital angular momentum (OAM) mode fiber laser with an all-polarization-maintaining fiber (PMF) structure based on a combination of two linearly polarized modes. The mode intensity ratio between the two linearly polarized modes can be adjusted by adopting a double-pump structure. A pair of polarization-maintaining long-period fiber gratings (PM-LPFGs) are used as a mode converter. The number of topological charges of the OAM mode beam can be tuned between +1 and -1 by stretching the fiber. By adopting an all-PMF structure, we can build an OAM mode fiber laser without a polarization controller and that is resistant to environmental disturbances. The purity of the OAM mode was approximately 93.6%. This stable and compact OAM mode fiber laser can be used as a laser source in practical applications and scientific research.

Few-mode random fiber laser with a switchable oscillating spatial mode.

Random fiber lasers are of tremendous interest to diverse applications for optical fiber sensing, speckle-free imaging. To date, random fiber lasers with fundamental mode oscillation have been well developed. However, controllable oscillating spatial mode in random fiber lasers have not been reported yet. Here, we propose and demonstrate a few-mode random fiber laser with a switchable oscillating spatial mode based on mode injection locking. An external signal light is injected to realize the locking of transverse mode in this random fiber laser and the direct oscillations of the fundamental mode, hybrid mode, and high order mode can be realized, respectively. This random fiber laser operates in the high-order LP11 mode stably with a threshold of as low as 88 mW. High efficiency and high purity cylindrical vector beams can be obtained by removing the degeneracy of the LP11 mode. This work may pave a path towards random fiber lasers with controllable spatial modes for specific applications in mode division multiplexing, imaging, and laser material processing.

Stable generation of cylindrical vector beams with an all-fiber laser using polarization-maintaining and ring-core fibers.

An all-fiber laser using polarization-maintaining and ring-core fibers that are capable of automatically generating stable TE01 and TM01 modes is proposed and demonstrated experimentally. Two vector-mode coupling long-period fiber gratings (LPFGs) fabricated by a high-frequency CO2 laser are used in the fiber laser to realize efficient coupling between HE11 mode and TE01/TM01 mode. The polarization dependence of the LPFGs is simulated using the coupled-mode theory and verified by experiments. A ring-core fiber is employed to support the stable propagation of TE01 and TM01 modes. By carefully aligning the polarization direction of the input light, the mode coupling ratios of both LPFGs exceed 15 dB. The mode purities of TE01 and TM01 modes are 92.4% and 97.3%, respectively. Owing to the all-polarization-maintaining structure, the laser output is highly stable under environmental disturbance. This laser can be used as a stable cylindrical vector beam source for a wide range of applications, including surface plasmon excitation, optical tweezers, high-resolution metrology and so on.

Generation of mode-locked square-shaped and chair-like pulse based on reverse saturable absorption effect of nonlinear multimode interference.

In this paper, the phenomenon of reverse saturable absorption of offset-spliced graded index multimode fibers (OS-GIMF) is revealed. And based on that, the stable square-shaped and chair-like mode-locked pulses are demonstrated with the maximum pulse energy of 0.14 µJ and 23.8 nJ respectively, while the OS-GIMF acts as a saturable absorber (SA) in fiber laser. By adjusting polarization controller (PC) and the pump power, square-shaped and chair-like pulse can be switched to each other. This multimode SA could sever as high power light source owing to its high damage threshold, compact structure and low cost.

Chirp-adjustable square-wave pulse in a passively mode-locked fiber laser.

A passively mode-locked fiber laser to generate chirp-adjustable square-wave pulses is reported. A simple chirp measurement system is designed to study the output chirp of the fiber laser. The results indicate that the chirp of the square-wave pulses in our fiber laser can be adjusted by the polarization controllers inside the cavity. Three typical chirp states, including random chirp, V-shaped chirp and linear chirp, are achieved. This kind of fiber laser cannot only help to further understand the characteristics of square-wave pulse but also serve as multifunction light source for potential applications.

HoPE: Horizontal Plane Extractor for Cluttered 3D Scenes.

Extracting horizontal planes in heavily cluttered three-dimensional (3D) scenes is an essential procedure for many robotic applications. Aiming at the limitations of general plane segmentation methods on this subject, we present HoPE, a Horizontal Plane Extractor that is able to extract multiple horizontal planes in cluttered scenes with both organized and unorganized 3D point clouds. It transforms the source point cloud in the first stage to the reference coordinate frame using the sensor orientation acquired either by pre-calibration or an inertial measurement unit, thereby leveraging the inner structure of the transformed point cloud to ease the subsequent processes that use two concise thresholds for producing the results. A revised region growing algorithm named Z clustering and a principal component analysis (PCA)-based approach are presented for point clustering and refinement, respectively. Furthermore, we provide a nearest neighbor plane matching (NNPM) strategy to preserve the identities of extracted planes across successive sequences. Qualitative and quantitative evaluations of both real and synthetic scenes demonstrate that our approach outperforms several state-of-the-art methods under challenging circumstances, in terms of robustness to clutter, accuracy, and efficiency. We make our algorithm an off-the-shelf toolbox which is publicly available.

Image Mosaicking Approach for a Double-Camera System in the GaoFen2 Optical Remote Sensing Satellite Based on the Big Virtual Camera.

The linear array push broom imaging mode is widely used for high resolution optical satellites (HROS). Using double-cameras attached by a high-rigidity support along with push broom imaging is one method to enlarge the field of view while ensuring high resolution. High accuracy image mosaicking is the key factor of the geometrical quality of complete stitched satellite imagery. This paper proposes a high accuracy image mosaicking approach based on the big virtual camera (BVC) in the double-camera system on the GaoFen2 optical remote sensing satellite (GF2). A big virtual camera can be built according to the rigorous imaging model of a single camera; then, each single image strip obtained by each TDI-CCD detector can be re-projected to the virtual detector of the big virtual camera coordinate system using forward-projection and backward-projection to obtain the corresponding single virtual image. After an on-orbit calibration and relative orientation, the complete final virtual image can be obtained by stitching the single virtual images together based on their coordinate information on the big virtual detector image plane. The paper subtly uses the concept of the big virtual camera to obtain a stitched image and the corresponding high accuracy rational function model (RFM) for concurrent post processing. Experiments verified that the proposed method can achieve seamless mosaicking while maintaining the geometric accuracy.