Detalhe da pesquisa
1.
Design, synthesis, and evaluation of thiazolecarboxamide derivatives as stimulator of interferon gene inhibitors.
Mol Divers
; 2024 Apr 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-38683489
2.
A Novel IRAK4 Inhibitor DW18134 Ameliorates Peritonitis and Inflammatory Bowel Disease.
Molecules
; 29(8)2024 Apr 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38675622
3.
Design, synthesis, and STING-agonistic activity of benzo[b]thiophene-2-carboxamide derivatives.
Mol Divers
; 2023 Oct 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37796389
4.
Discovery and structure - activity relationship exploration of pyrazolo[1,5-a]pyrimidine derivatives as potent FLT3-ITD inhibitors.
Bioorg Med Chem
; 48: 116422, 2021 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34583130
5.
DW14383 is an irreversible pan-FGFR inhibitor that suppresses FGFR-dependent tumor growth in vitro and in vivo.
Acta Pharmacol Sin
; 42(9): 1498-1506, 2021 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-33288861
6.
Synthesis of triazolotriazine derivatives as c-Met inhibitors.
Mol Divers
; 25(2): 839-846, 2021 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-32157572
7.
DW14006 as a direct AMPKα1 activator improves pathology of AD model mice by regulating microglial phagocytosis and neuroinflammation.
Brain Behav Immun
; 90: 55-69, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32739363
8.
Rational Design, synthesis and biological evaluation of novel triazole derivatives as potent and selective PRMT5 inhibitors with antitumor activity.
J Comput Aided Mol Des
; 33(8): 775-785, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31312965
9.
Evaluation of Deuterium-Labeled JNJ38877605: Pharmacokinetic, Metabolic, and in Vivo Antitumor Profiles.
Chem Res Toxicol
; 31(11): 1213-1218, 2018 11 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-30284817
10.
Design, synthesis and biological evaluation of pyrazolylaminoquinazoline derivatives as highly potent pan-fibroblast growth factor receptor inhibitors.
Bioorg Med Chem Lett
; 26(11): 2594-9, 2016 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27117427
11.
DW10075, a novel selective and small-molecule inhibitor of VEGFR, exhibits antitumor activities both in vitro and in vivo.
Acta Pharmacol Sin
; 37(3): 398-407, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-26806300
12.
DW09849, a selective phosphatidylinositol 3-kinase (PI3K) inhibitor, prevents PI3K signaling and preferentially inhibits proliferation of cells containing the oncogenic mutation p110α (H1047R).
J Pharmacol Exp Ther
; 348(3): 432-41, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24361696
13.
Identification of DW532 as a novel anti-tumor agent targeting both kinases and tubulin.
Acta Pharmacol Sin
; 35(7): 916-28, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24858311
14.
Discovery of hematopoietic progenitor kinase 1 inhibitors using machine learning-based screening and free energy perturbation.
J Biomol Struct Dyn
; : 1-13, 2024 Jan 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-38198294
15.
Discovery of a 1,6-naphthyridin-4-one-based AXL inhibitor with improved pharmacokinetics and enhanced in vivo antitumor efficacy.
Eur J Med Chem
; 265: 116045, 2024 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-38128234
16.
Mycophenolic acid derivative 118 improves outcome of skin grafts by suppressing IL-17 production.
Acta Pharmacol Sin
; 34(7): 921-9, 2013 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-23645010
17.
Discovery of 10H-Benzo[b]pyrido[2,3-e][1,4]oxazine AXL Inhibitors via Structure-Based Drug Design Targeting c-Met Kinase.
J Med Chem
; 66(1): 220-234, 2023 01 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36524812
18.
Design, synthesis and pharmacological evaluation of 2,3-dihydrobenzofuran IRAK4 inhibitors for the treatment of diffuse large B-cell lymphoma.
Eur J Med Chem
; 256: 115453, 2023 Aug 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37163947
19.
Preclinical and early clinical studies of a novel compound SYHA1813 that efficiently crosses the blood-brain barrier and exhibits potent activity against glioblastoma.
Acta Pharm Sin B
; 13(12): 4748-4764, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-38045044
20.
2-Methyl-3-(1H-pyrazol-3-yl)imidazo[1,2-a]pyrimidine.
Acta Crystallogr Sect E Struct Rep Online
; 68(Pt 7): o1977, 2012 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22807811