Detalhe da pesquisa
1.
Natural killer cell therapies.
Nature
; 626(8000): 727-736, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38383621
2.
Self-eating limits EGFR-dependent tumor growth.
Cell
; 154(6): 1184-6, 2013 Sep 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-24034240
3.
Reciprocal regulation of amino acid import and epigenetic state through Lat1 and EZH2.
EMBO J
; 34(13): 1773-85, 2015 Jul 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-25979827
4.
Targeting S-adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A.
Nat Chem Biol
; 13(7): 785-792, 2017 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-28553945
5.
Macroautophagy is dispensable for growth of KRAS mutant tumors and chloroquine efficacy.
Proc Natl Acad Sci U S A
; 113(1): 182-7, 2016 Jan 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-26677873
6.
PF-06463922 is a potent and selective next-generation ROS1/ALK inhibitor capable of blocking crizotinib-resistant ROS1 mutations.
Proc Natl Acad Sci U S A
; 112(11): 3493-8, 2015 Mar 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-25733882
7.
Leveraging model-based study designs and serial micro-sampling techniques to understand the oral pharmacokinetics of the potent LTB4 inhibitor, CP-105696, for mouse pharmacology studies.
Xenobiotica
; 47(7): 600-606, 2017 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-27435693
8.
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate.
Nature
; 462(7274): 739-44, 2009 Dec 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-19935646
9.
Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance.
Cancer Cell
; 9(6): 425-34, 2006 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-16766262
10.
Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor genotyping.
Oncologist
; 17(1): 72-9, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22180306
11.
Non-invasive detection of 2-hydroxyglutarate and other metabolites in IDH1 mutant glioma patients using magnetic resonance spectroscopy.
J Neurooncol
; 107(1): 197-205, 2012 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-22015945
12.
A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth.
Cancer Cell
; 2(1): 29-42, 2002 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-12150823
13.
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate.
Nature
; 465(7300): 966, 2010 Jun 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-20559394
14.
Missense mutations in the BCS1L gene as a cause of the Björnstad syndrome.
N Engl J Med
; 356(8): 809-19, 2007 Feb 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-17314340
15.
Orally Bioavailable Small-Molecule CD73 Inhibitor (OP-5244) Reverses Immunosuppression through Blockade of Adenosine Production.
J Med Chem
; 63(18): 10433-10459, 2020 09 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-32865411
16.
Discovery of a Potent Steroidal Glucocorticoid Receptor Antagonist with Enhanced Selectivity against the Progesterone and Androgen Receptors (OP-3633).
J Med Chem
; 62(14): 6751-6764, 2019 07 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-31274313
17.
Palbociclib and Fulvestrant Act in Synergy to Modulate Central Carbon Metabolism in Breast Cancer Cells.
Metabolites
; 9(1)2019 Jan 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30609717
18.
Mechanisms of resistance to histone deacetylase inhibitors and their therapeutic implications.
Clin Cancer Res
; 13(24): 7237-42, 2007 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18094401
19.
Discovery of a Potent and Selective Steroidal Glucocorticoid Receptor Antagonist (ORIC-101).
J Med Chem
; 61(17): 7767-7784, 2018 09 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30091920
20.
Characterization of the Selective Indoleamine 2,3-Dioxygenase-1 (IDO1) Catalytic Inhibitor EOS200271/PF-06840003 Supports IDO1 as a Critical Resistance Mechanism to PD-(L)1 Blockade Therapy.
Mol Cancer Ther
; 17(12): 2530-2542, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30232146