Detalhe da pesquisa
1.
The Multifaceted Role of GPCRs in Amyotrophic Lateral Sclerosis: A New Therapeutic Perspective?
Int J Mol Sci
; 23(9)2022 Apr 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35562894
2.
A Computational Workflow for the Identification of Novel Fragments Acting as Inhibitors of the Activity of Protein Kinase CK1δ.
Int J Mol Sci
; 22(18)2021 Sep 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34575906
3.
Design, Synthesis and Evaluation of New Indolylpyrimidylpiperazines for Gastrointestinal Cancer Therapy.
Molecules
; 24(20)2019 Oct 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31614517
4.
Discovery of simplified N²-substituted pyrazolo[3,4-d]pyrimidine derivatives as novel adenosine receptor antagonists: efficient synthetic approaches, biological evaluations and molecular docking studies.
Bioorg Med Chem
; 22(5): 1751-65, 2014 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24518296
5.
Gaucher Disease: A Glance from a Medicinal Chemistry Perspective.
ChemMedChem
; 19(10): e202300641, 2024 May 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-38329692
6.
Structural Investigations on 2-Amidobenzimidazole Derivatives as New Inhibitors of Protein Kinase CK1 Delta.
Pharmaceuticals (Basel)
; 17(4)2024 Apr 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-38675428
7.
The A3 adenosine receptor as multifaceted therapeutic target: pharmacology, medicinal chemistry, and in silico approaches.
Med Res Rev
; 33(2): 235-335, 2013 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-22095687
8.
Fluorescent ligands for adenosine receptors.
Bioorg Med Chem Lett
; 23(1): 26-36, 2013 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23200243
9.
Revisiting a receptor-based pharmacophore hypothesis for human A(2A) adenosine receptor antagonists.
J Chem Inf Model
; 53(7): 1620-37, 2013 Jul 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-23705857
10.
Are Two Riboses Better Than One? The Case of the Recognition and Activation of Adenosine Receptors.
ChemMedChem
; 18(14): e202300109, 2023 07 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-37114338
11.
Pyrazolo-triazolo-pyrimidine Scaffold as a Molecular Passepartout for the Pan-Recognition of Human Adenosine Receptors.
Biomolecules
; 13(11)2023 11 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38002292
12.
"Dual Anta-Inhibitors" of the A2A Adenosine Receptor and Casein Kinase CK1delta: Synthesis, Biological Evaluation, and Molecular Modeling Studies.
Pharmaceuticals (Basel)
; 16(2)2023 Jan 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-37259317
13.
[1,2,4]Triazolo[1,5-c]pyrimidines as Tools to Investigate A3 Adenosine Receptors in Cancer Cell Lines.
ChemMedChem
; 18(21): e202300299, 2023 11 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-37675643
14.
A novel conjugated agent between dopamine and an A2A adenosine receptor antagonist as a potential anti-Parkinson multitarget approach.
Mol Pharm
; 9(3): 591-604, 2012 Mar 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-22292533
15.
Glycogen Synthase Kinase 3ß Involvement in Neuroinflammation and Neurodegenerative Diseases.
Curr Med Chem
; 29(27): 4631-4697, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35170406
16.
Riluzole-Rasagiline Hybrids: Toward the Development of Multi-Target-Directed Ligands for Amyotrophic Lateral Sclerosis.
ACS Chem Neurosci
; 13(15): 2252-2260, 2022 08 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35868251
17.
Pharmacophore elucidation for a new series of 2-aryl-pyrazolo-triazolo-pyrimidines as potent human A3 adenosine receptor antagonists.
Bioorg Med Chem Lett
; 21(10): 2898-905, 2011 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21511471
18.
Does the combination of optimal substitutions at the C²-, N5- and N8-positions of the pyrazolo-triazolo-pyrimidine scaffold guarantee selective modulation of the human A3 adenosine receptors?
Bioorg Med Chem
; 19(20): 6120-34, 2011 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21908194
19.
Potent and selective A3 adenosine receptor antagonists bearing aminoesters as heterobifunctional moieties.
RSC Med Chem
; 12(2): 254-262, 2021 Mar 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-34046614
20.
Developing novel classes of protein kinase CK1δ inhibitors by fusing [1,2,4]triazole with different bicyclic heteroaromatic systems.
Eur J Med Chem
; 216: 113331, 2021 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33721670