Detalhe da pesquisa
1.
Survey of Pharmaceutical Industry's Best Practices around In Vitro Transporter Assessment and Implications for Drug Development: Considerations from the International Consortium for Innovation and Quality for Pharmaceutical Development Transporter Working Group.
Drug Metab Dispos
; 52(7): 582-596, 2024 Jun 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-38697852
2.
Molecular Mechanisms for Species Differences in Organic Anion Transporter 1, OAT1: Implications for Renal Drug Toxicity.
Mol Pharmacol
; 94(1): 689-699, 2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29720497
3.
Amplifying the impact of kidney microphysiological systems: predicting renal drug clearance using mechanistic modelling based on reconstructed drug secretion.
ALTEX
; 40(3): 408-424, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36343109
4.
In vitro evaluation of hepatic transporter-mediated clinical drug-drug interactions: hepatocyte model optimization and retrospective investigation.
Drug Metab Dispos
; 40(6): 1085-92, 2012 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-22381335
5.
Mechanistic pharmacokinetic modeling for the prediction of transporter-mediated disposition in humans from sandwich culture human hepatocyte data.
Drug Metab Dispos
; 40(5): 1007-17, 2012 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-22344703
6.
Differential modulation of cytochrome P450 activity and the effect of 1-aminobenzotriazole on hepatic transport in sandwich-cultured human hepatocytes.
Drug Metab Dispos
; 40(2): 407-11, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22031626
7.
pH-Dependent solubility and permeability criteria for provisional biopharmaceutics classification (BCS and BDDCS) in early drug discovery.
Mol Pharm
; 9(5): 1199-212, 2012 May 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-22489626
8.
The evolution of the OATP hepatic uptake transport protein family in DMPK sciences: from obscure liver transporters to key determinants of hepatobiliary clearance.
Xenobiotica
; 42(1): 28-45, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-22077101
9.
A comprehensive non-clinical evaluation of the CNS penetration potential of antimuscarinic agents for the treatment of overactive bladder.
Br J Clin Pharmacol
; 72(2): 235-46, 2011 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-21392072
10.
Refining the in vitro and in vivo critical parameters for P-glycoprotein, [I]/IC50 and [I2]/IC50, that allow for the exclusion of drug candidates from clinical digoxin interaction studies.
Mol Pharm
; 7(2): 398-411, 2010 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-20025245
11.
Current State of In vitro Cell-Based Renal Models.
Curr Drug Metab
; 19(4): 310-326, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29357789
12.
Absolute immunoquantification of the expression of ABC transporters P-glycoprotein, breast cancer resistance protein and multidrug resistance-associated protein 2 in human liver and duodenum.
Biochem Pharmacol
; 83(2): 279-85, 2012 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22062654
13.
Targeting intestinal transporters for optimizing oral drug absorption.
Curr Drug Metab
; 11(9): 730-42, 2010 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-21189135
14.
N-(3,4-dimethoxyphenethyl)-4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2[1H]-yl)-6,7-dimethoxyquinazolin-2-amine (CP-100,356) as a "chemical knock-out equivalent" to assess the impact of efflux transporters on oral drug absorption in the rat.
J Pharm Sci
; 98(12): 4914-27, 2009 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19373887