The synthesis of solid supports carrying base labile linkers to generate 3'-phosphate oligonucleotides.

Oligonucleotides carrying 3'-terminal phosphates and conjugates are important tools in molecular biology and diagnostic purposes. We described the preparation of solid supports carrying the base labile linker 4-((2-hydroxyethyl)sulfonyl)benzamide for the solid-phase synthesis of 3'-phosphorylated oligonucleotides. These supports are fully compatible with the phosphoramidite chemistry yielding the desired 3'-phosphate oligonucleotides in excellent yields. The use of mild deprotection conditions allows the generation of partially protected DNA fragments.

Lunar Lithium-7 Sensing (δ7Li): Spectral Patterns and Artificial Intelligence Techniques.

Lithium, a critical natural resource integral to modern technology, has influenced diverse industries since its discovery in the 1950s. Of particular interest is lithium-7, the most prevalent lithium isotope on Earth, playing a vital role in applications such as batteries, metal alloys, medicine, and nuclear research. However, its extraction presents significant environmental and logistical challenges. This article explores the potential for lithium exploration on the Moon, driven by its value as a resource and the prospect of cost reduction due to the Moon's lower gravity, which holds promise for future space exploration endeavors. Additionally, the presence of lithium in the solar wind and its implications for material transport across celestial bodies are subjects of intrigue. Drawing from a limited dataset collected during the Apollo missions (Apollo 12, 15, 16, and 17) and leveraging artificial intelligence techniques and sample expansion through bootstrapping, this study develops predictive models for lithium-7 concentration based on spectral patterns. The study areas encompass the Aitken crater, Hadley Rima, and the Taurus-Littrow Valley, where higher lithium concentrations are observed in basaltic lunar regions. This research bridges lunar geology and the formation of the solar system, providing valuable insights into celestial resources and enhancing our understanding of space. The data used in this study were obtained from the imaging sensors (infrared, visible, and ultraviolet) of the Clementine satellite, which significantly contributed to the success of our research. Furthermore, the study addresses various aspects related to statistical analysis, sample quality validation, resampling, and bootstrapping. Supervised machine learning model training and validation, as well as data import and export, were explored. The analysis of data generated by the Clementine probe in the near-infrared (NIR) and ultraviolet-visible (UVVIS) spectra revealed evidence of the presence of lithium-7 (Li-7) on the lunar surface. The distribution of Li-7 on the lunar surface is non-uniform, with varying concentrations in different regions of the Moon identified, supporting the initial hypothesis associating surface Li-7 concentration with exposure to solar wind. While a direct numerical relationship between lunar topography and Li-7 concentration has not been established due to morphological diversity and methodological limitations, preliminary results suggest significant economic and technological potential in lunar lithium exploration and extraction.

Cortical microinfarcts in adults with Down syndrome assessed with 3T-MRI.

BACKGROUND: Cortical microinfarcts (CMI) were attributed to cerebrovascular disease and cerebral amyloid angiopathy (CAA). CAA is frequent in Down syndrome (DS) while hypertension is rare, yet no studies have assessed CMI in DS. METHODS: We included 195 adults with DS, 63 with symptomatic sporadic Alzheimer's disease (AD), and 106 controls with 3T magnetic resonance imaging. We assessed CMI prevalence in each group and CMI association with age, AD clinical continuum, vascular risk factors, vascular neuroimaging findings, amyloid/tau/neurodegeneration biomarkers, and cognition in DS. RESULTS: CMI prevalence was 11.8% in DS, 4.7% in controls, and 17.5% in sporadic AD. In DS, CMI increased in prevalence with age and the AD clinical continuum, was clustered in the parietal lobes, and was associated with lacunes and cortico-subcortical infarcts, but not hemorrhagic lesions. DISCUSSION: In DS, CMI are posteriorly distributed and related to ischemic but not hemorrhagic findings suggesting they might be associated with a specific ischemic CAA phenotype. HIGHLIGHTS: This is the first study to assess cortical microinfarcts (assessed with 3T magnetic resonance imaging) in adults with Down syndrome (DS). We studied the prevalence of cortical microinfarcts in DS and its relationship with age, the Alzheimer's disease (AD) clinical continuum, vascular risk factors, vascular neuroimaging findings, amyloid/tau/neurodegeneration biomarkers, and cognition. The prevalence of cortical microinfarcts was 11.8% in DS and increased with age and along the AD clinical continuum. Cortical microinfarcts were clustered in the parietal lobes, and were associated with lacunes and cortico-subcortical infarcts, but not hemorrhagic lesions. In DS, cortical microinfarcts are posteriorly distributed and related to ischemic but not hemorrhagic findings suggesting they might be associated with a specific ischemic phenotype of cerebral amyloid angiopathy.

Characterization of white matter hyperintensities in Down syndrome.

INTRODUCTION: In Down syndrome (DS), white matter hyperintensities (WMHs) are highly prevalent, yet their topography and association with sociodemographic data and Alzheimer's disease (AD) biomarkers remain largely unexplored. METHODS: In 261 DS adults and 131 euploid controls, fluid-attenuated inversion recovery magnetic resonance imaging scans were segmented and WMHs were extracted in concentric white matter layers and lobar regions. We tested associations with AD clinical stages, sociodemographic data, cerebrospinal fluid (CSF) AD biomarkers, and gray matter (GM) volume. RESULTS: In DS, total WMHs arose at age 43 and showed stronger associations with age than in controls. WMH volume increased along the AD continuum, particularly in periventricular regions, and frontal, parietal, and occipital lobes. Associations were found with CSF biomarkers and temporo-parietal GM volumes. DISCUSSION: WMHs increase 10 years before AD symptom onset in DS and are closely linked with AD biomarkers and neurodegeneration. This suggests a direct connection to AD pathophysiology, independent of vascular risks. HIGHLIGHTS: White matter hyperintensities (WMHs) increased 10 years before Alzheimer's disease symptom onset in Down syndrome (DS). WMHs were strongly associated in DS with the neurofilament light chain biomarker. WMHs were more associated in DS with gray matter volume in parieto-temporal areas.

Effect of Obstructive Sleep Apnea during Pregnancy on Fetal Development: Gene Expression Profile of Cord Blood.

Obstructive sleep apnea (OSA) is quite prevalent during pregnancy and is associated with adverse perinatal outcomes, but its potential influence on fetal development remains unclear. This study investigated maternal OSA impact on the fetus by analyzing gene expression profiles in whole cord blood (WCB). Ten women in the third trimester of pregnancy were included, five OSA and five non-OSA cases. WCB RNA expression was analyzed by microarray technology to identify differentially expressed genes (DEGs) under OSA conditions. After data normalization, 3238 genes showed significant differential expression under OSA conditions, with 2690 upregulated genes and 548 downregulated genes. Functional enrichment was conducted using gene set enrichment analysis (GSEA) applied to Gene Ontology annotations. Key biological processes involved in OSA were identified, including response to oxidative stress and hypoxia, apoptosis, insulin response and secretion, and placental development. Moreover, DEGs were confirmed through qPCR analyses in additional WCB samples (7 with OSA and 13 without OSA). This highlighted differential expression of several genes in OSA (EGR1, PFN1 and PRKAR1A), with distinct gene expression profiles observed during rapid eye movement (REM)-OSA in pregnancy (PFN1, UBA52, EGR1, STX4, MYC, JUNB, and MAPKAP). These findings suggest that OSA, particularly during REM sleep, may negatively impact various biological processes during fetal development.

Intraoral Scanning for Monitoring Dental Wear and Its Risk Factors: A Prospective Study.

Dental wear arises from mechanical (attrition or abrasion) and chemical (erosion) factors. Despite its prevalence and clinical significance, accurately measuring and understanding its causes remain challenging in everyday practice. This one-year study with 39 participants involved comprehensive examinations and full-arch intraoral scans at the start and after 12 months. Volume loss exceeding 100 µ on each tooth's surfaces (buccal, lingual/palatine and incisal/occlusal) was measured by comparing three-dimensional scans from both time points. This study also assessed factors such as abrasion and erosion through clinical exams and questionnaires. There were no significant differences in dental wear in participants with sleep bruxism. However, noticeable wear occurred in the front teeth of those with waking bruxism and joint-related symptoms. Increased wear was associated with frequent consumption of acidic drinks, regular swimming, dry mouth, nocturnal drooling and heartburn, while no significant wear was found in patients with reflux. The used methodology proved effective in accurately assessing the progression of dental wear, which is important as many patients may initially be asymptomatic. The variability observed in dental wear patterns underscores the need to develop specific software applications that allow immediate and efficient comparison of wear areas based on extensive analysis of patient databases.

Posttraumatic Scrotal Reconstruction with a Pedicled "Extended" Superficial Circumflex Iliac Artery Perforator Flap: A Case Report.

The superficial circumflex iliac artery (SCIA) perforator (SCIP) flap has been used for scrotal reconstruction after Fournier's gangrene, skin cancer, or infections. However, there are few publications with regard to penoscrotal reconstruction after a traumatic injury with this flap. In this article, we propose a new SCIP flap variation, the "extended" or "direct" SCIP flap, to effectively reconstruct a wide scrotal defect after a traumatic injury. The "extended" SCIP flap is designed medial and cranial to the anterosuperior iliac spine (ASIS) using the superficial branch of the SCIA as the main pedicle.

Gender-Based Differences in Psychological, Nutritional, Physical Activity, and Oral Health Factors Associated with Stress in Teachers.

The aim of this study was to analyze gender differences in stress-related factors among active teachers. A cross-sectional study was conducted to examine gender disparities in psychological, nutritional, physical activity, and oral health factors and how these habits correlate with stress and burnout in their work environment. The sample comprised 1037 teachers from Spain, Colombia, and Chile, consisting of 40.1% men and 59.9% women, with an average age of 41 years and teaching experience of 11.8 ± 9.2 and 12.2 ± 8.7 years, respectively. They were evaluated using a compilation of questionnaires with the objective of analyzing gender differences in habits that are associated with stress levels in teachers. The findings revealed that men had significantly higher levels of depersonalization and personal accomplishment, whereas women exhibited higher levels of perceived stress and conscientiousness. Regarding nutritional habits, results were more positive for women, and men exhibited healthier functional habits by engaging in more weekly sports. Regarding oral health habits, women had better oral hygiene practices, brushing their teeth more frequently. However, women showed a higher tendency to smoke than their male counterparts. We conclude that there are notable gender differences that can provide insights for developing strategies to enhance the overall well-being of teachers.

Joint response from Latin American, European Obstetric Violence Observatories and others organizations all over Europe to the Joint Position Statement on Substandard and Disrespectful Care in Labour - Because Words Matter.

The issue of obstetric violence is internationally acknowledged as a serious violation of human rights. First identified by the Committee of Experts of the Inter-American Belém do Pará Convention in 2012, it is recognized as a form of gender-based violence that infringes upon women's rights during childbirth. Nations such as Argentina, Mexico, Venezuela, and certain regions in Spain have implemented laws against it, highlighting its severity and the need for protective legislation. Major international organizations, including WHO and the Council of Europe, advocate for the elimination of disrespectful and abusive treatment in maternity care. In 2019, the UN Special Rapporteur on violence against women called on states to protect women's human rights in reproductive services by enforcing laws, prosecuting perpetrators, and providing compensation to victims. However, despite advances, there remains institutional and systemic resistance to recognizing obstetric violence, which undermines trust in healthcare and impacts women's quality of life. Addressing this violence is imperative, requiring education and training in women's human rights for all healthcare professionals. As part of the coalition of experts from various organizations (InterOVO), we respond to the publication by EAPM, EBCOG, and EMA: "Joint Position Statement: Substandard and Disrespectful Care in Labor - Because Words Matter." We are committed to preventing and mitigating obstetric violence and improving care for women and newborns.

Associations of Microbleeds and Their Topography With Imaging and CSF Biomarkers of Alzheimer Pathology in Individuals With Down Syndrome.

BACKGROUND AND OBJECTIVES: Cerebral hemorrhages are an exclusion criterion and potential adverse effect of antiamyloid agents. It is, therefore, critical to characterize the natural history of cerebral microbleeds in populations genetically predisposed to Alzheimer disease (AD), such as Down syndrome (DS). We aimed to assess microbleed emergence in adults with DS across the AD spectrum, defining their topography and associations with clinical variables, cognitive outcomes, and fluid and neuroimaging biomarkers. METHODS: This cross-sectional study included participants aged 18 years or older from the Down-Alzheimer Barcelona Neuroimaging Initiative and Sant Pau Initiative on Neurodegeneration with T1-weighted and susceptibility-weighted images. Participants underwent comprehensive assessments, including apolipoprotein E (APOE) genotyping; fluid and plasma determinations of beta-amyloid, tau, and neurofilament light; cognitive outcomes (Cambridge Cognitive Examination and modified Cued Recall Test); and vascular risk factors (hypertension, diabetes mellitus, and dyslipidemia). We manually segmented microbleeds and characterized their topography. Associations between microbleed severity and AD biomarkers were explored using between-group comparisons (none vs 1 vs 2+) and multivariate linear models. RESULTS: We included 276 individuals with DS and 158 healthy euploid controls (mean age = 47.8 years, 50.92% female). Individuals with DS were more likely to have microbleeds than controls (20% vs 8.9%, p < 0.001), with more severe presentation (12% with 2+ vs 1.9%). Microbleeds increased with age (12% 20-30 years vs 60% > 60 years) and AD clinical stage (12.42% asymptomatic, 27.9% prodromal, 35.09% dementia) were more common in APOEε4 carriers (26% vs 18.3% noncarriers, p = 0.008), but not associated with vascular risk factors (p > 0.05). Microbleeds were predominantly posterior (cerebellum 33.66%; occipital 14.85%; temporal 21.29%) in participants with DS. Associations with microbleed severity were found for neuroimaging and fluid AD biomarkers, but only hippocampal volumes (standardized ß = -0.18 [-0.31, -0.06], p < 0.005) and CSF p-tau-181 concentrations (ß = 0.26 [0.12, 0.41], p < 0.005) survived regression controlling for age and disease stage, respectively. Microbleeds had limited effect on cognitive outcomes. DISCUSSION: In participants with DS, microbleeds present with a posterior, lobar predominance, are associated with disease severity, but do not affect cognitive performance. These results suggest an interplay between AD pathology and vascular lesions, implicating microbleeds as a risk factor limiting the use of antiamyloid agents in this population.

Personalizing Nutrition Strategies: Bridging Research and Public Health.

In recent years, although life expectancy has increased significantly, non-communicable diseases (NCDs) continue to pose a significant threat to the health of the global population. Therefore, eating habits have been recognized as key modifiable factors that influence people's health and well-being. For this reason, it is interesting to study dietary patterns, since the human diet is a complex mixture of macronutrients, micronutrients, and bioactive compounds, and can modulate multiple physiological processes, including immune function, the metabolism, and inflammation. To ensure that the data we acquired were current and relevant, we searched primary and secondary sources, including scientific journals, bibliographic indexes, and databases in the last 15 years with the most relevant articles. After this search, we observed that all the recent research on NCDs suggests that diet is a critical factor in shaping an individual's health outcomes. Thus, cardiovascular, metabolic, mental, dental, and visual health depends largely on the intake, habits and patterns, and nutritional behaviors. A diet high in processed and refined foods, added sugars, and saturated fats can increase the risk of developing chronic diseases. On the other hand, a diet rich in whole, nutrient-dense foods, such as vegetables, fruits, nuts, legumes, and a high adherence to Mediterranean diet can improve health's people.

Keeping prior anticoagulation treatment in the acute phase of ischaemic stroke: the REKOALA study.

INTRODUCTION: A consensus on the management of anticoagulated patients in the acute phase of ischaemic stroke has not yet been established. We aimed to evaluate clinical outcomes in such patients based on the continuation or discontinuation of anticoagulation. METHODS: Retrospective study of patients with acute ischaemic stroke and cardioembolic source receiving anticoagulant therapy is done. Patients were classified based on the continuation or discontinuation of anticoagulation at admission. Clinical outcomes, haemorrhagic and ischaemic events were assessed. Multivariate logistic regression analysis, propensity score matching (PSM) analysis and a sub-analysis of patients with severe ischaemic stroke at admission (NIHSS score ≥ 15) were performed. RESULTS: Anticoagulation was continued in 147 (78.8%) of 186 patients. Patients continuing anticoagulant had lower NIHSS (median 5 vs 18, p < 0.001). There were no differences in haemorrhagic or ischaemic events. In the multivariate analysis, good functional outcome at discharge was higher in the continuation group, OR (CI95%) 3.77 (1.2-11.2). PSM analysis adjusted for potential confounders such as NIHSS had higher rates of good functional outcomes at discharge (80% vs 36%, p = 0.004) and at 90 days (76% vs 44%, p = 0.042) in the continuation group. Patients with severe stroke in this group had lower 90-day mortality (34.6% vs 62.5%, p = 0.045) and higher rates of good clinical outcome at discharge (33.3% vs 8.3%, p = 0.032). No differences were observed in 90-day haemorrhagic or ischaemic events. CONCLUSION: Continuation of anticoagulation in patients with acute ischaemic stroke and cardioembolic source did not increase the risk of intracranial haemorrhage and may be associated with better functional outcomes.

Agresiones hacia profesionales en el ámbito de la salud / Assaults on professionals in healthcare settings

Objetivo. Determinar la frecuencia de agresiones al personal sanitario en una red social de profesionales de la salud y caracterizar aspectos que profundicen su comprensión y el desarrollo de estrategias de prevención. Métodos. Se realizó una encuesta electrónica voluntaria y confidencial a través del sitio web IntraMed. Se analizó la frecuencia de agresiones verbales y físicas y su asociación con variables demográficas, ocupación, carrera, especialidad, eventuales consecuencias, percepción de inseguridad en el lugar de trabajo y propuestas para reducirla. Resultados. Se analizaron 19 967 encuestas. En 13 323 (66,7%), se refirieron agresiones. El 11,3% de las agresiones fueron físicas. El 73,4% ocurrieron en instituciones públicas, principalmente en áreas de emergencia. Los desencadenantes más frecuentes fueron la demora en la atención y la carencia de recursos. Se informó, en los agresores, intoxicación por alcohol o drogas en 13,8%, estado mental alterado por otra causa o enfermedad psiquiátrica en 13,9%, y en 63% no se detectó alteración de las facultades mentales. En 16,9% de los casos se informaron secuelas en los profesionales agredidos, en 7,9% secuelas físicas y en 28% de los lesionados suspensión temporaria de la actividad laboral. En 46,6% se refirió inseguridad en el lugar de trabajo y se sugirieron diversas medidas para reducirla, entre las que se destacó la educación comunitaria. Conclusiones. La violencia verbal o física hacia el personal de la salud resultó frecuente, con la consecuencia de secuelas laborales, psíquicas e incluso físicas. La información aportada por este estudio podría utilizarse para desarrollar estrategias orientadas a su prevención y control.

Objective. Determine the frequency of assaults on health workers and characterize aspects that deepen understanding and development of prevention strategies. Methods. A voluntary and confidential electronic survey was conducted through the IntraMed website, a social network of health professionals. Frequency of verbal and physical assaults was analyzed along with their association with demographic variables, occupation, career, specialty, potential consequences, perception of insecurity in the workplace, and proposals to reduce them. Results. A total of 19 967 surveys were analyzed, of which 13 323 (66.7%) described assaults. Assaults were physical in 11.3% of cases, and 73.4% occurred in public institutions, mainly in emergency areas. Delay in care and lack of resources were the most frequent triggers. Alcohol or drug intoxication was reported in 13.8% of aggressors, altered mental status from another cause or psychiatric illness in 13.9%, and no detected impairment of mental faculties in 63%. Of professionals attacked, 16.9% reported sequelae, 7.9% of which were physical, and 28% were temporarily unable to work. Insecurity in the workplace was described by 46.6% of respondents, who suggested various measures to reduce it, chief among them, community education Conclusions. Verbal and physical violence toward health workers was frequent, resulting in work-related, mental, and even physical sequelae. This study contributes information that could be used to develop strategies aimed at prevention and control of assaults.

Agresiones hacia profesionales en el ámbito de la salud / Assaults on professionals in healthcare settings

OBJETIVO: Determinar la frecuencia de agresiones al personal sanitario en una red social de profesionales de la salud y caracterizar aspectos que profundicen su comprensión y el desarrollo de estrategias de prevención. MÉTODOS: Se realizó una encuesta electrónica voluntaria y confidencial a través del sitio web IntraMed. Se analizó la frecuencia de agresiones verbales y físicas y su asociación con variables demográficas, ocupación, carrera, especialidad, eventuales consecuencias, percepción de inseguridad en el lugar de trabajo y propuestas para reducirla. RESULTADOS: Se analizaron 19 967 encuestas. En 13 323 (66,7%), se refirieron agresiones. El 11,3% de las agresiones fueron físicas. El 73,4% ocurrieron en instituciones públicas, principalmente en áreas de emergencia. Los desencadenantes más frecuentes fueron la demora en la atención y la carencia de recursos. Se informó, en los agresores, intoxicación por alcohol o drogas en 13,8%, estado mental alterado por otra causa o enfermedad psiquiátrica en 13,9%, y en 63% no se detectó alteración de las facultades mentales. En 16,9% de los casos se informaron secuelas en los profesionales agredidos, en 7,9% secuelas físicas y en 28% de los lesionados suspensión temporaria de la actividad laboral. En 46,6% se refirió inseguridad en el lugar de trabajo y se sugirieron diversas medidas para reducirla, entre las que se destacó la educación comunitaria. CONCLUSIONES: La violencia verbal o física hacia el personal de la salud resultó frecuente, con la consecuencia de secuelas laborales, psíquicas e incluso físicas. La información aportada por este estudio podría utilizarse para desarrollar estrategias orientadas a su prevención y control.

OBJECTIVE: Determine the frequency of assaults on health workers and characterize aspects that deepen understanding and development of prevention strategies. METHODS: A voluntary and confidential electronic survey was conducted through the IntraMed website, a social network of health professionals. Frequency of verbal and physical assaults was analyzed along with their association with demographic variables, occupation, career, specialty, potential consequences, perception of insecurity in the workplace, and proposals to reduce them. RESULTS: A total of 19 967 surveys were analyzed, of which 13 323 (66.7%) described assaults. Assaults were physical in 11.3% of cases, and 73.4% occurred in public institutions, mainly in emergency areas. Delay in care and lack of resources were the most frequent triggers. Alcohol or drug intoxication was reported in 13.8% of aggressors, altered mental status from another cause or psychiatric illness in 13.9%, and no detected impairment of mental faculties in 63%. Of professionals attacked, 16.9% reported sequelae, 7.9% of which were physical, and 28% were temporarily unable to work. Insecurity in the workplace was described by 46.6% of respondents, who suggested various measures to reduce it, chief among them, community education CONCLUSIONS: Verbal and physical violence toward health workers was frequent, resulting in work-related, mental, and even physical sequelae. This study contributes information that could be used to develop strategies aimed at prevention and control of assaults.

Processing order in dual-tasks when the duration of motor responses varies / Orden de ejecución de dos tareas cuando la duración de las respuestas motoras varían

Recent studies reported that central processing duration influences processing order of two tasks in the psychological refractory period (PRP) paradigm. This study examined whether the duration of response execution influences the processing of task order. For this purpose, a tone discrimination task was combined with a letter discrimination task. Both tasks were presented in random order using different stimulus onset asynchronies (SOAs). In one condition, participants responded to each stimulus with a single key press (easy response condition). In the other condition, the tone task required a single key press, whereas the letter task required a more time-consuming key press-sequence (hard response condition). The results showed that participants tend to perform the tone task first more often when the response requirement for the letter task is hard, rather than easy. This result is consistent with the notion that participants optimize response scheduling in dual-task situations.

Bajo el paradigma de periodo refractario psicológico (PRP), recientes estudios han hallado que la duración del procesamiento central influye en el orden en el que dos tareas son procesadas. En el presente trabajo se examinó si la duración de la respuesta también influye en el orden en el que dos tareas se ejecutan. Para este propósito, se utilizó una tarea de discriminación auditiva en combinación con una tarea de discriminación visual. En el experimento se varió el orden de presentación de las tareas de forma aleatoria así como se utilizaron diferentes intervalos entre estímulos (stimulus onset asynchrony; SOA) En una condición, los participantes respondieron a cada estímulo pulsando una tecla (condición de respuesta simple). En la otra condición, mientras que a la tarea auditiva se respondía de nuevo pulsando una tecla, la respuesta a la tarea visual requería pulsar una secuencia de teclas, aumentando la duración de la respuesta (condición de respuesta compleja). Los resultados mostraron que los participantes tienden a ejecutar más a menudo la tarea auditiva en primer lugar cuando la respuesta de la tarea visual es más compleja. Este resultado apoya la noción de que, en escenarios de doble tarea, los participantes pueden invertir sus respuestas si con ello optimizan su ejecución.

Plan de accion para elevar conocimientos sobre embarazo y sus riesgos en adolescentes atendidas en el Hogar Materno Carlos J. Finlay / Plan of accion to elevate knowledge about pregnancy and their risks in pregnant adolescents assisted in the Maternal House Carlos J. Finlay

Introducción: el embarazo en la adolescencia es un problema de salud mundial. Objetivo: determinar los conocimientos sobre embarazo en la adolescencia y sus riesgos en adolescentes embarazadas atendidas en el Hogar Materno Carlos J. Finlay. Material y Métodos: se realizó un estudio descriptivo, de corte transversal con 86 adolescentes embarazadas entre 10 y 19 años, atendidas en el Hogar Materno Carlos J. Finlay en el período comprendido de diciembre del 2007 al 2010. Se revisaron las historias clínicas de las pacientes, se aplicó un cuestionario y se analizaron las variables. Resultados: la incidencia del embarazo en la adolescencia fue alta, prevaleció la adolescencia tardía; entre los factores de riesgos biológicos y psicosociales que agravan el embarazo fueron el estado nutricional deficiente seguido del peso menor de 45Kg o talla menor de 1.45 cm, en su gran mayoría se encontraban solteras y aún estudiando. Respecto a la edad de las primeras relaciones sexuales refirieron haberlas tenido entre los 14 y 16 años y tenían antecedentes obstétricos. Se observó que no tenían orientación sexual y el personal de la salud, junto a sus padres, no tenía un papel fundamental. El conocimiento sobre los riesgos biológicos, psicológicos y socioeconómicos era pobre. Conclusiones: el poco conocimiento sobre el embarazo en la adolescencia y sus riesgos es resultado de las características socioeconómicas y el origen de la orientación sexual que poseen. Recomendaciones: crear instrumentos y estrategias que den su aporte a la disminución de la incidencia mundial del embarazo en la adolescencia.

Introduction: pregnancy in the adolescence is a health problem all over the world. Objective: to determine the knowledge on pregnancy in the adolescence and their risks in the pregnant adolescents assisted in the maternal house Carlos J Finlay. Material and Methods: it was carried out a cross section descriptive study, with 86 pregnant adolescents among 10 and 19 years old assisted in the maternal house Carlos J Finlay between December 2007 and 2010. The clinical histories of the patients were revised, a questionnaire was applied and the variables were analyzed. Results: the incidence of the pregnancy in the adolescence was high, prevailing the late adolescence, the biological and psychosocial risks factors that increase pregnancy were the poor nutritional state, weight below 45Kg or size below 1.45 cm, the majority of them were single and still studying. About the age the first sexual relationships they referred to have them before 14 to 16 years old and they had obstetrics antecedents. It was observed that they didn't have sexual orientation and that the health care personnel and their parents didn't play a fundamental role. The knowledge about the biological, psychological and socioeconomic risks was poor. Conclusions: the poor knowledge on the pregnancy in the adolescence and its risks is a result of the socioeconomic characteristics and their poor sexual orientation. Recommendations: to create instruments and strategies that gives their contribution to the decrease the world incidence of pregnancy in the adolescence.

Interdisciplinariedad entre la Medicina General Integral y la Informática Médica relacionada con el desarrollo de una revisión bibliográfica / Interdisciplinarity between the Integral General Medicine and Medical Informatics related to the development of literature review

La revisión bibliográfica no es una publicación original y examina la bibliografía publicada, debe ser selectiva e imprescindible en la formación del médico. Para lograr con éxito la integración del Departamento de Medicina General Integral (MGI) y el de Informática, para perfeccionar la formación de los futuros médicos, teniendo en cuenta la revisión bibliográfica, se comienza en el primer semestre de la carrera de Medicina del curso escolar 2010-2011, la asignatura Introducción a la MGI. El Departamento de MGI al valorar la revisión bibliográfica como herramienta básica para la investigación junto al departamento de Informática, traza acciones que contribuyeron a desarrollar la integración de ambas asignaturas, se realizaron talleres para elevar la capacitación de los profesores y surgió la idea de desarrollar una propuesta metodológica y evaluar su impacto realizando en un mismo acto de examen la evaluación final de ambas asignaturas en el escenario docente donde se imparte la docencia, con el objetivo de integrar el conocimiento, aumentar la motivación y la habilidad para investigar. Se seleccionaron los 3 mejores trabajos otorgándoles 1ro, 2do y 3er lugar. Se llevó a cabo esta propuesta para obtener la interdisciplinariedad entre la MGI e Informática Médica enfatizando en la revisión bibliográfica, se lograron resultados satisfactorios, tuvo objetivos precisos y se encaminó a abordar todos los nudos críticos identificados por los profesores

Literature review is not an original article but it analyzes the published literature; it should be selective and indispensable in the medical formation. For succeeding in integrating the Department of Integral General Medicine (MGI in Cuba) and the Department of Informatics, and for improving the formation of future physicians, the first semester of the medical studies in the 2010-2011 academic year included the subject Introduction to Integral General Medicine, taking literature review into account. Since the MGI Department considered the literature review as a basic tool for research as did the Department of Informatics, it took actions to develop the integration of both subjects. To this end, some workshops were held to raise the level of training of professors and thus, it came out the idea of developing a methodological proposal and evaluating its impact by making the final evaluation of both subjects in one exam at the place where the classes were given. All this was aimed at integrating knowledge, encouraging motivation and increasing abilities for research. The three best papers were selected and given 1st, 2nd and 3rd prizes. This proposal was submitted to reach interdisciplinarity between the Integral General Medicine and Medical Informatics by making emphasis on the literature review. It achieved satisfactory results, had precise objectives and was aimed at dealing with all the critical issues identified by the professors

Registro Nacional de Internación por Insuficiencia Cardíaca 2007 / 2007 National Registry of Admissions due to Heart Failure

Introducción La insuficiencia cardíaca representa una de las principales causas de internación con una tasa elevada de complicaciones y cuyo enfoque no parece que haya mejorado en los último años. Objetivos Conocer el perfil epidemiológico y clínico, analizar las medidas terapéuticas y la evolución durante la internación y a los 3 meses de pacientes admitidos por insuficiencia cardíaca descompensada. Material y métodos Registro prospectivo, multicéntrico de pacientes internados por insuficiencia cardíaca descompensada en 31 centros de todo el país que aceptaron la invitación a participar del registro. Se analizaron variables vinculadas con la presentación y la evolución hospitalaria y a los 90 días. Resultados Se incluyeron 736 pacientes, mediana de edad 74 años (64-82), 41% mujeres, 75% hipertensos, 27% diabéticos, 20% infarto previo, 30% fibrilación auricular crónica, 17% insuficiencia renal crónica, 18% EPOC. Sólo el 29% era de etiología isquémico-necrótica. El 47% había tenido internación en el último año por insuficiencia cardíaca. Las causas de descompensación más frecuentes fueron infecciones, suspensión del tratamiento y transgresión alimentaria. Las formas graves de presentación (shock cardiogénico, edema agudo de pulmón, anasarca) representaron el 30%. El 60% de los pacientes se internaron en área crítica. La mediana de permanencia fue de 7 (5-11) días. La mortalidad hospitalaria fue del 8%. A los 90 días, la reinternación fue del 24,5% y la mortalidad posalta fue del 12,8%. Conclusiones El presente registro confirma que se trata de una población de edad avanzada con una incidencia alta de comorbilidades. Muchas descompensaciones ocurren por factores prevenibles. La tasa de complicaciones es elevada y no se redujo en la última década.

Introduction Heart failure represents one of the main causes of hospital admissions, with a high rate of complications; however, its approach does not seem to have improved during recent years. Objectives To become acquainted with the epidemiologycal and clincial profile; to analize the therapeutic measures and the evolution of patients who were admitted due to descompensated heart failure, during the period of hospitalization, and three months later. Material and Methods Prospective multicenter register of hospitalized patients due to descompensed heart failure in 31 facilities throughout the country that accepted the invitation to participate in the register. Variables related to the presentation and the hospital evolution were analized, as well as the variables 90 days after hospitalization. Results A total of 736 patients were included, with an average of 74 years of age (64-82), 41% women, 75% hypertensive, 27% diabetics, 20% previous infarction, 30% chronic atrial fibrillation, 17% chronic kidney failure, 18% COPD. Only 29% was of ischemic-necrosis etiology. 47% had been admitted over the last year due to heart failure. The most frequent causes of descompensation were infections, stopping treatment, and dietary indiscretion. The severe presentations (cardiogenic shock, acute pulmonary edema, anasarca) occurred in 30% of the individuals. 60% patients were admitted in the critical unit. The median stay in hospital was of 7 (5-11) days. In-hospital mortality was of 8%. After 90 days, readmittance was of 24.5%, and post discharge mortality was of 12.8%. Conclusions The present register confirms that this is a population made up of older adults with a high incidence of cormobilities. Many descompensations occur due to factors that may be prevented. The rate of complications is high and did not reduce over the last decade.

Tabaquismo en médicos de la República Argentina. Estudio TAMARA / Smoking among physicians in Argentina. The TAMARA trial

Objetivo: Analizar el tabaquismo en una muestra de médicos de la Argentina, los factores que favorecen su consumo y la conducta frente a sus pacientes fumadores. Material y métodos: El presente es un estudio observacional y transversal que incluyó médicos de la Argentina, seleccionados aleatoriamente desde abril a julio de 2004. Se analizaron la prevalencia de tabaquismo, los factores de riesgo coronario, el índice de masa corporal, la actividad física, el antecedente de eventos vasculares, los antecedentes familiares de coronariopatía y tabaquismo, si habían recibido entrenamiento en tabaquismo, si brindaban consejo para la cesación del hábito y la utilización de fármacos específicos. Resultados: Se encuestaron 6.497 médicos (63 por ciento varones, edad promedio 41,5 ± 10 años). La proporción de fumadores fue del 30,0 por ciento y la de ex fumadores, del 22,4 por ciento. Hubo mayor prevalencia de fumadores en servicios de urgencia (p < 0,0001) y en especialidades quirúrgicas (p < 0,00001), con un perfil de conducta adictiva y brindaban con menos frecuencia consejo para el abandono del hábito de fumar (p < 0,00001). Los que recibieron algún tipo de entrenamiento en tabaquismo (31,3 por ciento) brindaban consejo para el cese del hábito y prescribían fármacos específicos con más frecuencia (p < 0,00001). Los ex fumadores presentaron mayor prevalencia de factores de riesgo coronario, de IAM y de revascularización (p < 0,00001). Éstos y los fumadores tenían más antecedentes familiares de tabaquismo (p < 0,001). Conclusiones: Existe una elevada proporción de médicos fumadores, con mayor prevalencia en servicios de urgencia y quirúrgicos y brindan menos consejo antitabaco. El haber recibido entrenamiento se asoció con mayor uso de consejo y fármacos para la cesación de la adicción tabáquica, por lo que se plantea la necesidad de generalizar la capacitación médica en este tema.

Predictores de morbimortalidad en pacientes con insuficiencia cardíaca y función sistólica conservada / Predictors of disease progresion and mortality in patients with heart failure and preserved systolic function

Objetivos: El objetivo principal de este estudio es el de analizar las variables asociadas con mortalidad e internaciones por descompensación en pacientes con insuficiencia cardíaca y función sistólica conservada. Por otra parte, construímos y validamos una regla de predicción clínica de mortalidad en esta población. Material y métodos: A partir de 2279 pacientes incluídos en forma consecutiva en el registro GESICA de insuficiencia cardíaca, analizamos 401 individuos con fracción de eyección > 40 por ciento. Este grupo se caracterizó por tener un promedio de edad de 70 años, un 41 por ciento de mujeres, el 57 por ciento se hallaba en CF III/IV y el 24 por ciento tenía cardiopatía isquémica. Durante el seguimiento promedio de 540 días, el 14,4 por ciento de los pacientes se internaron al menos una vez por IC y el 15,2 por ciento fallecieron. Resultados: La única variable independiente asociada con la internación por insuficiencia cardíaca fue el múmero de internaciones en el año previo: HR 1,72 (1,0-2,97), p= 0,05; mayor ó menor 2 internaciones: HR 2,78 (1,15-6,72), p = 0,023. Las variables predictoras independientes de mortalidad fueron: clase funcional, uremia, natremia, enfermedad pulmonar obstructiva crónica, sexo masculino, índice de masa corporal y tensión arterial sistólica < 110 o > 140 mm Hg. El sexo masculino, la enfermedad pulmonar obstructiva crónica y la tensión arterial sistólica elevada predijeron mortalidad sólo en pacientes sin disfunción sistólica. Conclusión: En los pacientes con insuficiencia cardíaca y función sistólica conservada, las variables asociadas con una severidad clínica mayor predicen mayor mortalidad, mientras que las internaciones previas se asocian solamente con nuevas internaciones por insuficiencia cardíaca.