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J Med Food ; 17(6): 694-700, 2014 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-24476221

RESUMO

The present work reports the anti-inflammatory and antinociceptive activities of the ethanol extract obtained from the stem bark of Sterculia striata A. St.-Hil. & Naudin (Ss-EtOH) in the experimental models of edema induced by carrageenan, dextran, or histamin and nociception induced by chemical stimuli, such as acetic acid, formalin, capsaicin, or glutamate. The Ss-EtOH (50 mg/kg) promoted a marked inhibition on the hind paw edema induced by carrageenan or dextran (30% and 73%, respectively). Besides, Ss-EtOH (25 mg/kg) exhibited a slight activity (30%) on the hind paw edema induced by histamin. The Ss-EtOH (12.5 and 25 mg/kg) showed the antinociceptive activity on chemical stimuli induced by acetic acid (65.59% and 38.37%, respectively), formalin, in the initial (35.08% and 31.5%, respectively) and late phases (44.09% and 83.57%, respectively), capsaicin (43.77% and 51.31%, respectively), or glutamate (36.6% and 52.12%, respectively). Regarding the possible mechanism involved in the antinociceptive effect, Ss-EtOH (12.5 mg/kg) showed a decrease in the antinociceptive effect (65.8%) in the acetic acid model after pretreatment with naloxone. Thus, opioid mechanisms might be underlying this response.


Assuntos
Analgésicos/uso terapêutico , Anti-Inflamatórios/uso terapêutico , Inflamação/tratamento farmacológico , Dor/tratamento farmacológico , Fitoterapia , Extratos Vegetais/uso terapêutico , Sterculia , Ácido Acético , Analgésicos/farmacologia , Animais , Anti-Inflamatórios/farmacologia , Capsaicina , Carragenina , Dextranos , Edema/induzido quimicamente , Edema/tratamento farmacológico , Formaldeído , Ácido Glutâmico , Histamina , Inflamação/induzido quimicamente , Masculino , Camundongos , Naloxona/farmacologia , Casca de Planta , Extratos Vegetais/farmacologia , Caules de Planta , Ratos Wistar
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