Detalhe da pesquisa
1.
Synthesis and antiviral properties of novel 7-heterocyclic substituted 7-deaza-adenine nucleoside inhibitors of Hepatitis C NS5B polymerase.
Bioorg Med Chem
; 20(15): 4801-11, 2012 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22770556
2.
Development of 2-pyrrolidinyl-N-methyl pyrimidones as potent and orally bioavailable HIV integrase inhibitors.
Bioorg Med Chem Lett
; 20(17): 5031-4, 2010 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20674351
3.
Identification and SAR of novel pyrrolo[1,2-a]pyrazin-1(2H)-one derivatives as inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1).
Bioorg Med Chem Lett
; 20(3): 1094-9, 2010 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20031401
4.
N-(4-Fluorobenzyl)-3-hydroxy-9,9-dimethyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrazino[1,2-a]pyrimidine-2-carboxamides a novel class of potent HIV-1 integrase inhibitors.
Bioorg Med Chem Lett
; 19(15): 4245-9, 2009 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19523819
5.
Synthesis and evaluation of novel phosphoramidate prodrugs of 2'-methyl cytidine as inhibitors of hepatitis C virus NS5B polymerase.
Bioorg Med Chem Lett
; 19(5): 1392-5, 2009 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19181520
6.
Design and synthesis of bicyclic pyrimidinones as potent and orally bioavailable HIV-1 integrase inhibitors.
J Med Chem
; 51(4): 861-74, 2008 Feb 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-18217703
7.
Development of 2-t butyl-N-methyl pyrimidones as potent inhibitors of HIV integrase.
Bioorg Med Chem Lett
; 18(8): 2709-13, 2008 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18362069
8.
Optimization of a series of potent and selective ketone histone deacetylase inhibitors.
Bioorg Med Chem Lett
; 18(20): 5528-32, 2008 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18809328
9.
Endorectal ultrasonography performance in staging rectal cancer before and after neoadjuvant chemoradiotherapy.
Ann Ital Chir
; 85(6): 569-75, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25711540
10.
Discovery of (7R)-14-cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylic acid (MK-3281), a potent and orally bioavailable finger-loop inhibitor of the hepatitis C virus NS5B polymerase.
J Med Chem
; 54(1): 289-301, 2011 Jan 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-21141896
11.
Rectal villous tumours: MR features and correlation with TRUS in the preoperative evaluation.
Eur J Radiol
; 73(2): 329-33, 2010 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-19157738
12.
Enhancement of intestinal absorption of 2-methyl cytidine prodrugs.
Drug Deliv
; 17(4): 214-22, 2010 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-20233089
13.
Discovery of a potent class I selective ketone histone deacetylase inhibitor with antitumor activity in vivo and optimized pharmacokinetic properties.
J Med Chem
; 52(11): 3453-6, 2009 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-19441846
14.
Novel macrocyclic inhibitors of hepatitis C NS3/4A protease featuring a 2-amino-1,3-thiazole as a P4 carbamate replacement.
J Med Chem
; 52(22): 7014-28, 2009 Nov 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-19856919
15.
Inhibitors of the hepatitis C virus NS3 protease with basic amine functionality at the P3-amino acid N-terminus: discovery and optimization of a new series of P2-P4 macrocycles.
J Med Chem
; 52(15): 4820-37, 2009 Aug 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-19624135
16.
Cyclic phosphoramidates as prodrugs of 2'-C-methylcytidine.
Eur J Med Chem
; 44(9): 3765-70, 2009 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-19493593
17.
Phosphoramidate prodrugs of 2'-C-methylcytidine for therapy of hepatitis C virus infection.
J Med Chem
; 52(17): 5394-407, 2009 Sep 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-19725579
18.
Optimization of thienopyrrole-based finger-loop inhibitors of the hepatitis C virus NS5B polymerase.
ChemMedChem
; 4(10): 1695-713, 2009 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-19672916
19.
Discovery of raltegravir, a potent, selective orally bioavailable HIV-integrase inhibitor for the treatment of HIV-AIDS infection.
J Med Chem
; 51(18): 5843-55, 2008 Sep 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-18763751
20.
The metamorphosis of supernova SN 2008D/XRF 080109: a link between supernovae and GRBs/hypernovae.
Science
; 321(5893): 1185-8, 2008 Aug 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-18653846