The association of a decreased level of awareness and blood alcohol concentration with both agitation and sedation in intoxicated patients in the ED.

OBJECTIVE: This study was conducted to compare the level of awareness as determined by serial bispectral index (BIS) electroencephalogram scores to a standardized Altered Mental Status (AMS) scale used to define a patient's clinical level of agitation or sedation, and the patient's concurrent breath/blood alcohol concentration (BAC). METHODS: This was an institutional review board-approved, prospective observational study of a convenience sample of patients who presented to the emergency department (ED) with the chief complaint of ethanol (ETOH) intoxication between July 19, 2003, and March 27, 2004. The AMS scale is a 9-point scale: -4 is unresponsive, 0 is normal examination, and +4 is extremely agitated. After ETOH was detected by breath analyzer, enrolled patients had a BIS monitor probe applied to their forehead. Baseline BAC, BIS, and AMS scores were recorded independently of the patients' caregivers. Bispectral index and AMS scores were repeated every 20 minutes for 1 hour. The patient's diagnosis, disposition, (any) complications, and total time in department were recorded. RESULTS: Ninety-eight patients were enrolled in the study. The median presenting AMS score was -1. The mean total time in department was 402.6 minutes (SD, 196.4; range, 246-906 minutes). The mean presenting BIS score was 77.6 (SD, 17.9; range, 26-98). The mean presenting BAC was 0.229 (SD, 0.07; range, 0.049-0.43). The mean BIS index varied from 59.6 +/- 16.9 for AMS scores of -4, to 96.3 +/- 2.7 for AMS scores of 0, to 90.5 +/- 4.9 for AMS scores of 4. The AMS scale correlated with the BIS scale (Spearman's rho = 0.67, P < or = .001), but did not correlate with BAC (Spearman's rho = -0.14, P = 0.15). CONCLUSIONS: Changes in the AMS scale corresponded to changes in the BIS index score. A decreased level of awareness, as determined on the BIS index, was observed in patients who were either agitated or sedated by the AMS. We conclude that both agitated and sedated patients with ETOH intoxication show decreases in their level of awareness. Therefore, the AMS scale, which includes both agitation and sedation, is a valid measure of a patient's decreased level of awareness.

Occult depressive symptoms in adolescent emergency department patients.

OBJECTIVES: To estimate the frequency of occult depressive symptoms in adolescent emergency department (ED) patients (aged 13-17 years) and to determine patient characteristics associated with depressive symptoms. DESIGN: A cross-sectional study of adolescent ED patients. SETTING: The pediatric ED of Hennepin County Medical Center in Minneapolis, Minnesota, and the EDs of the Children's Hospitals and Clinics of Minnesota. PATIENTS: Medically stable adolescent ED patients with nonpsychiatric concerns. INTERVENTIONS: Patients completed the Beck Depression Inventory II and answered questions about their attitudes, activities, and lifestyle choices. Guardians were asked about family demographics, living situations, and other patient characteristics. MAIN OUTCOME MEASURES: The frequency of moderate and severe depressive symptoms as measured by the Beck Depression Inventory II. Group results were analyzed with descriptive statistics; patient characteristics associated with depressive symptoms were determined by multivariate analysis. RESULTS: A total of 967 patients were enrolled. According to the Beck Depression Inventory II, 20% (197 patients) had moderate to severe depressive symptoms. Of these, 58% recognized their depressive symptoms and 50% were recognized by their guardians as having depressive symptoms. When compared with nondepressed patients, adolescents with depressive symptoms more often were female, were not involved in organized social activities, knew someone who intentionally hurt himself or herself or died a violent death, were currently involved in a sexual relationship, or used street drugs. Race, family income, family stability, and witnessing violence were not associated with a positive depression screen result. CONCLUSIONS: Depressive symptoms occur frequently among adolescents and are often unrecognized. Efforts to increase awareness of depression among ED physicians, adolescents, and parents of adolescents may be beneficial.

Serial Bispectral index scores in patients undergoing observation for sedative overdose in the emergency department.

STUDY OBJECTIVE: Many patients who overdose on sedatives experience a declining mental status and eventually require endotracheal intubation. The goal of this study was to determine if serial bedside Bispectral index (BIS) scores monitoring can be used to detect the eventual need for intubation in overdosed patients who are undergoing observation in the ED. METHODS: This was a prospective, observational study of a convenience sample of patients who presented to the Hennepin County Medical Center ED between June and November 2002. Patients being treated and observed for a suspected sedative ingestion were eligible. Upon presentation, a Bispectral electroencephalographic probe was applied to the patient's forehead, and a BIS score was recorded at 0 and 20 minutes. The Altered Mental Status scale was used to describe the patient's clinical status. Data were collected by trained research assistants. Data are described with descriptive statistics. The mean changes in BIS score between patients who did and did not require intubation are compared with t tests, and the outcome of patients with stable vs declining BIS scores were compared with chi(2) tests. RESULTS: Seventy-six patients were enrolled. The mean initial BIS score was 83.9 (95% CI, 79.7-88.1; range, 9-99). The mean change in BIS scores during the 20-minute observation period for the patients who required intubation was -13.5 (95% CI, -30.2 to 3.2) and was +6.7 (95% CI, 3.3-10.1) for those who were not intubated. Sixteen patients had an initial BIS score below 70. Of these patients, 6 were intubated. All intubations occurred during the 20 minutes, and this group had a mean initial BIS of 47.2 (95% CI, 35.6-58.8). The 10 patients with an initial BIS below 70 who were not intubated had a mean increase in BIS score of 23.3 (95% CI, 11.7-33.9) during the 20 minutes. Of the 60 patients whose first BIS score was above 70, 5 were eventually intubated during their ED treatment. The mean change in BIS was -36.4 (95% CI, -18.7 to -54.1) for the intubated patients vs +7.9 (95% CI, 4.4-11.3) for nonintubated patients during the first 20 minutes. CONCLUSION: The overdosed patients who required intubation during their ED treatment experienced a mean decrease in BIS during the first 20 minutes, compared with those who did not. Bispectral index scores monitoring may prove useful for earlier ED treatment and decision making regarding sedative overdose patients.