Detalhe da pesquisa
1.
Sustained metabolic benefits of ΔTRTX-Ac1, a tarantula venom-derived peptide, when administered together with exenatide in high-fat fed mice.
Diabetes Obes Metab
; 26(1): 329-338, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-37818589
2.
Enzymatically stable analogue of the gut-derived peptide xenin on beta-cell transdifferentiation in high fat fed and insulin-deficient Ins1Cre/+ ;Rosa26-eYFP mice.
Diabetes Metab Res Rev
; 37(3): e3384, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-32662136
3.
Dapagliflozin and Liraglutide Therapies Rapidly Enhanced Bone Material Properties and Matrix Biomechanics at Bone Formation Site in a Type 2 Diabetic Mouse Model.
Calcif Tissue Int
; 107(3): 281-293, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32642787
4.
Exendin-4(Lys27 PAL)/gastrin/xenin-8-Gln: A novel acylated GLP-1/gastrin/xenin hybrid peptide that improves metabolic status in obese-diabetic (ob/ob) mice.
Diabetes Metab Res Rev
; 35(3): e3106, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30499633
5.
Emerging therapeutic potential for xenin and related peptides in obesity and diabetes.
Diabetes Metab Res Rev
; 34(6): e3006, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29633491
6.
Sustained high-fat diet modulates inflammation, insulin signalling and cognition in mice and a modified xenin peptide ameliorates neuropathology in a chronic high-fat model.
Diabetes Obes Metab
; 20(5): 1166-1175, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29316242
7.
An enzymatically stable GIP/xenin hybrid peptide restores GIP sensitivity, enhances beta cell function and improves glucose homeostasis in high-fat-fed mice.
Diabetologia
; 60(3): 541-552, 2017 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28004148
8.
A novel chemically modified analogue of xenin-25 exhibits improved glucose-lowering and insulin-releasing properties.
Biochim Biophys Acta
; 1860(4): 757-64, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26802310
9.
Locally produced xenin and the neurotensinergic system in pancreatic islet function and ß-cell survival.
Biol Chem
; 399(1): 79-92, 2017 12 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-28822218
10.
Sequential induction of beta cell rest and stimulation using stable GIP inhibitor and GLP-1 mimetic peptides improves metabolic control in C57BL/KsJ db/db mice.
Diabetologia
; 58(9): 2144-53, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-26048235
11.
A novel DPP IV-resistant C-terminally extended glucagon analogue exhibits weight-lowering and diabetes-protective effects in high-fat-fed mice mediated through glucagon and GLP-1 receptor activation.
Diabetologia
; 57(9): 1927-36, 2014 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-24962667
12.
A novel glucagon-like peptide-1 (GLP-1)/glucagon hybrid peptide with triple-acting agonist activity at glucose-dependent insulinotropic polypeptide, GLP-1, and glucagon receptors and therapeutic potential in high fat-fed mice.
J Biol Chem
; 288(49): 35581-91, 2013 Dec 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-24165127
13.
A novel acylated form of (d-Ala(2))GIP with improved antidiabetic potential, lacking effect on body fat stores.
Biochim Biophys Acta
; 1830(6): 3407-13, 2013 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-23518200
14.
Does GIPR blockade as well as agonism have a role to play in management of obesity and diabetes?
J Endocrinol
; 2024 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38861364
15.
Chronic exposure to incretin metabolites GLP-1(9-36) and GIP(3-42) affect islet morphology and beta cell health in high fat fed mice.
Peptides
; 178: 171254, 2024 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-38815655
16.
Glucose-dependent insulinotropic polypeptide receptor knockout mice are impaired in learning, synaptic plasticity, and neurogenesis.
J Neurophysiol
; 105(4): 1574-80, 2011 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-21273318
17.
Characterization and biological actions of N-terminal truncated forms of glucose-dependent insulinotropic polypeptide.
Biochem Biophys Res Commun
; 404(3): 870-6, 2011 Jan 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-21184739
18.
Administration of an acylated GLP-1 and GIP preparation provides added beneficial glucose-lowering and insulinotropic actions over single incretins in mice with Type 2 diabetes and obesity.
Clin Sci (Lond)
; 121(3): 107-17, 2011 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-21332446
19.
Xenin and Related Peptides: Potential Therapeutic Role in Diabetes and Related Metabolic Disorders.
Clin Med Insights Endocrinol Diabetes
; 14: 11795514211043868, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34588834
20.
Therapeutic Potential of Peptides Derived from Animal Venoms: Current Views and Emerging Drugs for Diabetes.
Clin Med Insights Endocrinol Diabetes
; 14: 11795514211006071, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34621137