Detalhe da pesquisa
1.
Repression of sphingosine kinase (SK)-interacting protein (SKIP) in acute myeloid leukemia diminishes SK activity and its re-expression restores SK function.
J Biol Chem
; 295(16): 5496-5508, 2020 04 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-32161116
2.
A Phase Ib Study of NUC-1031 in Combination with Cisplatin for the First-Line Treatment of Patients with Advanced Biliary Tract Cancer (ABC-08).
Oncologist
; 26(4): e669-e678, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33210382
3.
Single Peptide Backbone Surrogate Mutations to Regulate Angiotensin GPCR Subtype Selectivity.
Chemistry
; 26(47): 10690-10694, 2020 Aug 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-32691857
4.
Anti-tumour activity of a first-in-class agent NUC-1031 in patients with advanced cancer: results of a phase I study.
Br J Cancer
; 119(7): 815-822, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30206366
5.
Clofarabine, high-dose cytarabine and liposomal daunorubicin in pediatric relapsed/refractory acute myeloid leukemia: a phase IB study.
Haematologica
; 103(9): 1484-1492, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29773602
6.
Arginine deprivation using pegylated arginine deiminase has activity against primary acute myeloid leukemia cells in vivo.
Blood
; 125(26): 4060-8, 2015 Jun 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-25896651
7.
Development of a physiologically based pharmacokinetic model of actinomycin D in children with cancer.
Br J Clin Pharmacol
; 81(5): 989-98, 2016 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-26727248
8.
Development of HPLC-UV method for rapid and sensitive analysis of topically applied tetracaine: its comparison with a CZE method.
Biomed Chromatogr
; 28(6): 826-30, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24861750
9.
A role for macrophages under cytokine control in mediating resistance to ADI-PEG20 (pegargiminase) in ASS1-deficient mesothelioma.
Pharmacol Rep
; 75(3): 570-584, 2023 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-37010783
10.
Synthesis and Characterization of NUC-7738, an Aryloxy Phosphoramidate of 3'-Deoxyadenosine, as a Potential Anticancer Agent.
J Med Chem
; 65(23): 15789-15804, 2022 12 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-36417756
11.
Single Diastereomers of the Clinical Anticancer ProTide Agents NUC-1031 and NUC-3373 Preferentially Target Cancer Stem Cells In Vitro.
J Med Chem
; 64(12): 8179-8193, 2021 06 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-34085825
12.
A Phase Ib Open-Label, Dose-Escalation Study of NUC-1031 in Combination with Carboplatin for Recurrent Ovarian Cancer.
Clin Cancer Res
; 27(11): 3028-3038, 2021 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33741651
13.
Albendazole and its metabolites in the breast milk of lactating women following a single oral dose of albendazole.
Br J Clin Pharmacol
; 68(5): 737-42, 2009 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-19916998
14.
Correction: A role for macrophages under cytokine control in mediating resistance to ADI-PEG20 (pegargiminase) in ASS1-deficient mesothelioma.
Pharmacol Rep
; 75(3): 753, 2023 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-37195562
15.
Pharmacological factors affecting accumulation of gemcitabine's active metabolite, gemcitabine triphosphate.
Pharmacogenomics
; 18(9): 911-925, 2017 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-28594276
16.
Phosphoproteomic comparison of Pik3ca and Pten signalling identifies the nucleotidase NT5C as a novel AKT substrate.
Sci Rep
; 7: 39985, 2017 01 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28059163
17.
Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism.
Nat Commun
; 8(1): 1804, 2017 11 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-29180704
18.
Inhibition of the Polyamine Synthesis Pathway Is Synthetically Lethal with Loss of Argininosuccinate Synthase 1.
Cell Rep
; 16(6): 1604-1613, 2016 08 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27452468
19.
Dual-action combination therapy enhances angiogenesis while reducing tumor growth and spread.
Cancer Cell
; 27(1): 123-37, 2015 Jan 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-25584895
20.
Development and validation of an ultra-high performance LC-MS/MS assay for intracellular SN-38 in human solid tumour cell lines: comparison with a validated HPLC-fluorescence method.
J Chromatogr B Analyt Technol Biomed Life Sci
; 969: 213-8, 2014 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25195021