Detalhe da pesquisa
1.
An Enzymatic Route to the Synthesis of Tricyclic Fused Hexahydrofuranofuran P2-Ligand for a Series of Highly Potent HIV-1 Protease Inhibitors.
Tetrahedron Lett
; 1402024 Apr 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38586565
2.
Total Synthesis of Neuroprotective Agents, (+)-Lycibarbarine A and (-)-Lycibarbarine B.
J Org Chem
; 88(13): 9530-9536, 2023 07 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37267592
3.
Evaluation of darunavir-derived HIV-1 protease inhibitors incorporating P2' amide-derivatives: Synthesis, biological evaluation and structural studies.
Bioorg Med Chem Lett
; 83: 129168, 2023 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36738797
4.
SARS-CoV-2 papain-like protease (PLpro) inhibitory and antiviral activity of small molecule derivatives for drug leads.
Bioorg Med Chem Lett
; 96: 129489, 2023 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37770002
5.
Synthesis of optically active SARS-CoV-2 Mpro inhibitor drug nirmatrelvir (Paxlovid): an approved treatment of COVID-19.
Org Biomol Chem
; 21(28): 5768-5774, 2023 07 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-37293830
6.
Fluorine Modifications Contribute to Potent Antiviral Activity against Highly Drug-Resistant HIV-1 and Favorable Blood-Brain Barrier Penetration Property of Novel Central Nervous System-Targeting HIV-1 Protease Inhibitors In Vitro.
Antimicrob Agents Chemother
; 66(2): e0171521, 2022 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34978889
7.
Asymmetric 1,2-Carbamoyl Rearrangement of Lithiated Chiral Oxazolidine Carbamates and Diastereoselective Synthesis of α-Hydroxy Amides.
Chemistry
; 28(43): e202200941, 2022 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35587995
8.
Convergent synthesis of (+)-carambolaflavone A, an antidiabetic agent using a bismuth triflate-catalyzed C-aryl glycosylation.
Org Biomol Chem
; 20(14): 2822-2830, 2022 04 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35156978
9.
Total Syntheses of the Proposed Structure of Iriomoteolide-1a, -1b and Synthesis of Three Derivatives for Structural Studies.
Mar Drugs
; 20(10)2022 Sep 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-36286411
10.
Novel HIV PR inhibitors with C4-substituted bis-THF and bis-fluoro-benzyl target the two active site mutations of highly drug resistant mutant PRS17.
Biochem Biophys Res Commun
; 566: 30-35, 2021 08 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-34111669
11.
Highly Diastereoselective Intramolecular Asymmetric Oxidopyrylium-olefin [5 + 2] Cycloaddition and Synthesis of 8-Oxabicyclo[3.2.1]oct-3-enone Containing Ring Systems.
J Org Chem
; 86(12): 8127-8142, 2021 06 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-34015224
12.
Enantioselective Total Synthesis of (+)-EBC-23, a Potent Anticancer Agent from the Australian Rainforest.
J Org Chem
; 86(9): 6351-6360, 2021 05 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33872504
13.
The Chiron Approach to (3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-ol, a Key Subunit of HIV-1 Protease Inhibitor Drug, Darunavir.
J Org Chem
; 86(1): 1216-1222, 2021 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33267583
14.
Design and synthesis of herboxidiene derivatives that potently inhibit in vitro splicing.
Org Biomol Chem
; 19(6): 1365-1377, 2021 02 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-33480941
15.
Spliceostatins and Derivatives: Chemical Syntheses and Biological Properties of Potent Splicing Inhibitors.
J Nat Prod
; 84(5): 1681-1706, 2021 05 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-33974423
16.
Synthesis of amide derivatives for electron deficient amines and functionalized carboxylic acids using EDC and DMAP and a catalytic amount of HOBt as the coupling reagents.
Tetrahedron Lett
; 632021 Jan 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-33456089
17.
Chloropyridinyl Esters of Nonsteroidal Anti-Inflammatory Agents and Related Derivatives as Potent SARS-CoV-2 3CL Protease Inhibitors.
Molecules
; 26(19)2021 Sep 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-34641337
18.
Fluorescent Probes for Monitoring Serine Ubiquitination.
Biochemistry
; 59(13): 1309-1313, 2020 04 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32207972
19.
Lewis Acid-Catalyzed Vinyl Acetal Rearrangement of 4,5-Dihydro-1,3-dioxepines: Stereoselective Synthesis of cis- and trans-2,3-Disubstituted Tetrahydrofurans.
J Org Chem
; 85(16): 10399-10412, 2020 08 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-32806103
20.
Copper-Catalyzed Stille Cross-Coupling Reaction and Application in the Synthesis of the Spliceostatin Core Structure.
J Org Chem
; 85(12): 8111-8120, 2020 06 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-32515594