Detalhe da pesquisa
1.
Integrating Pharmacokinetic-Pharmacodynamic Modeling and Physiologically Based Pharmacokinetic Modeling to Optimize Human Dose Predictions for Plasmodium falciparum Malaria: a Chloroquine Case Study.
Antimicrob Agents Chemother
; 67(5): e0134522, 2023 05 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-37010410
2.
Spiropyrimidinetriones: a Class of DNA Gyrase Inhibitors with Activity against Mycobacterium tuberculosis and without Cross-Resistance to Fluoroquinolones.
Antimicrob Agents Chemother
; 66(4): e0219221, 2022 04 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35266826
3.
Toward New Transmission-Blocking Combination Therapies: Pharmacokinetics of 10-Amino-Artemisinins and 11-Aza-Artemisinin and Comparison with Dihydroartemisinin and Artemether.
Antimicrob Agents Chemother
; 65(8): e0099021, 2021 07 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-34097488
4.
Investigating Sulfoxide-to-Sulfone Conversion as a Prodrug Strategy for a Phosphatidylinositol 4-Kinase Inhibitor in a Humanized Mouse Model of Malaria.
Antimicrob Agents Chemother
; 62(12)2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30249687
5.
Artemisone and Artemiside Are Potent Panreactive Antimalarial Agents That Also Synergize Redox Imbalance in Plasmodium falciparum Transmissible Gametocyte Stages.
Antimicrob Agents Chemother
; 62(8)2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29866868
6.
In Vitro and In Vivo Pharmacokinetics of Aminoalkylated Diarylpropanes NP085 and NP102.
Antimicrob Agents Chemother
; 60(5): 3065-9, 2016 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-26953201
7.
Optimization of a multi-well colorimetric assay to determine haem species in Plasmodium falciparum in the presence of anti-malarials.
Malar J
; 14: 253, 2015 Jun 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-26099266
8.
Efficacy and pharmacokinetic evaluation of a novel anti-malarial compound (NP046) in a mouse model.
Malar J
; 14: 8, 2015 Jan 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-25563929
9.
The development and validation of an LC-MS/MS method for the determination of a new anti-malarial compound (TK900D) in human whole blood and its application to pharmacokinetic studies in mice.
Malar J
; 13: 42, 2014 Jan 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-24484513
10.
hERG, Plasmodium Life Cycle, and Cross Resistance Profiling of New Azabenzimidazole Analogues of Astemizole.
ACS Med Chem Lett
; 15(4): 463-469, 2024 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38628794
11.
A Water-Soluble Polymer-Lumefantrine Conjugate for the Intravenous Treatment of Severe Malaria.
Macromol Biosci
; 23(5): e2200518, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36999404
12.
The evaluation of ADME and pharmacokinetic properties of decoquinate derivatives for the treatment of malaria.
Front Pharmacol
; 13: 957690, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36091789
13.
Novel 3-Trifluoromethyl-1,2,4-oxadiazole Analogues of Astemizole with Multi-stage Antiplasmodium Activity and In Vivo Efficacy in a Plasmodium berghei Mouse Malaria Infection Model.
J Med Chem
; 65(24): 16695-16715, 2022 12 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36507890
14.
The anticancer human mTOR inhibitor sapanisertib potently inhibits multiple Plasmodium kinases and life cycle stages.
Sci Transl Med
; 14(667): eabo7219, 2022 10 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-36260689
15.
Antimalarial Benzimidazole Derivatives Incorporating Phenolic Mannich Base Side Chains Inhibit Microtubule and Hemozoin Formation: Structure-Activity Relationship and In Vivo Oral Efficacy Studies.
J Med Chem
; 64(8): 5198-5215, 2021 04 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33844521
16.
The Artemiside-Artemisox-Artemisone-M1 Tetrad: Efficacies against Blood Stage P. falciparum Parasites, DMPK Properties, and the Case for Artemiside.
Pharmaceutics
; 13(12)2021 Dec 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34959347
17.
Identification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite Plasmodium falciparum and Optimization Efforts.
J Med Chem
; 64(4): 2291-2309, 2021 02 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-33573376
18.
Identification of 2,4-Disubstituted Imidazopyridines as Hemozoin Formation Inhibitors with Fast-Killing Kinetics and In Vivo Efficacy in the Plasmodium falciparum NSG Mouse Model.
J Med Chem
; 63(21): 13013-13030, 2020 11 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33103428
19.
The palladacycle complex AJ-5 induces apoptotic cell death while reducing autophagic flux in rhabdomyosarcoma cells.
Cell Death Discov
; 5: 60, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-30701092
20.
Structure-Activity Relationship Studies and Plasmodium Life Cycle Profiling Identifies Pan-Active N-Aryl-3-trifluoromethyl Pyrido[1,2- a]benzimidazoles Which Are Efficacious in an in Vivo Mouse Model of Malaria.
J Med Chem
; 62(2): 1022-1035, 2019 01 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-30562027