Detalhe da pesquisa
1.
Cligosiban, A Novel Brain-Penetrant, Selective Oxytocin Receptor Antagonist, Inhibits Ejaculatory Physiology in Rodents.
J Sex Med
; 15(12): 1698-1706, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30527053
2.
The translational efficacy of a nonsteroidal progesterone receptor antagonist, 4-[3-cyclopropyl-1-(mesylmethyl)-5-methyl-1H-pyrazol-4-yl]oxy,-2,6-dimethylbenzonitrile (PF-02413873), on endometrial growth in macaque and human.
J Pharmacol Exp Ther
; 339(2): 642-53, 2011 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-21849626
3.
Preclinical and clinical pharmacokinetics of PF-02413873, a nonsteroidal progesterone receptor antagonist.
Drug Metab Dispos
; 39(8): 1396-405, 2011 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-21543556
4.
Drugging DNA Damage Repair Pathways for Trinucleotide Repeat Expansion Diseases.
J Huntingtons Dis
; 10(1): 203-220, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-32925081
5.
Discovery of a First-In-Class Small Molecule Antagonist against the Adrenomedullin-2 Receptor: Structure-Activity Relationships and Optimization.
J Med Chem
; 64(6): 3299-3319, 2021 03 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-33666424
6.
Discovery of a First-in-Class Potent Small Molecule Antagonist against the Adrenomedullin-2 Receptor.
ACS Pharmacol Transl Sci
; 3(4): 706-719, 2020 Aug 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-32832872
7.
In vitro and in vivo SAR of pyrido[3,4-d]pyramid-4-ylamine based mGluR1 antagonists.
Bioorg Med Chem Lett
; 19(8): 2190-4, 2009 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19289283
8.
Design and Identification of a Novel, Functionally Subtype Selective GABAA Positive Allosteric Modulator (PF-06372865).
J Med Chem
; 62(12): 5773-5796, 2019 06 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-30964988
9.
Total synthesis of cis-sylvaticin.
Org Lett
; 10(12): 2489-92, 2008 Jun 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-18489103
10.
Quantitative Chemical Proteomic Profiling of Ubiquitin Specific Proteases in Intact Cancer Cells.
ACS Chem Biol
; 11(12): 3268-3272, 2016 12 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-27779380
11.
The Discovery of a Potent, Selective, and Peripherally Restricted Pan-Trk Inhibitor (PF-06273340) for the Treatment of Pain.
J Med Chem
; 59(22): 10084-10099, 2016 11 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-27766865
12.
Novel Amino-pyrazole Ureas with Potent In Vitro and In Vivo Antileishmanial Activity.
J Med Chem
; 58(24): 9615-24, 2015 Dec 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-26571076
13.
Discovery and Optimization of Selective Nav1.8 Modulator Series That Demonstrate Efficacy in Preclinical Models of Pain.
ACS Med Chem Lett
; 6(6): 650-4, 2015 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-26101568
14.
Stereocontrolled Total Synthesis of (+)-Altohyrtin A/Spongistatin 1.
Angew Chem Int Ed Engl
; 40(21): 4055-4060, 2001 Nov 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29712249
15.
Rapid discovery of a novel series of Abl kinase inhibitors by application of an integrated microfluidic synthesis and screening platform.
J Med Chem
; 56(7): 3033-47, 2013 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-23441572
16.
Stereocontrolled Total Synthesis of (+)-Altohyrtin A/Spongistatin 1 Financial support was provided by the EPSRC (GR/L41646), Cambridge Commonwealth Trust (Scholarship to M.J.C.), EC (Marie Curie Postdoctoral Fellowship to J.L.A.), DFG (Postdoctoral Fellowship to T.T.), NSERC-Canada (Postdoctoral Fellowship to R.M.O.), Churchill College (Research Fellowship to D.J.W.), Kingapos;s College and Sims Fund, Cambridge (Scholarship to D.Y.K.C.). We also thank Merck and AstraZeneca Pharmaceuticals for generous support, and Dr. Anne Butlin (AZ) and Dr. Nick Bampos (Cambridge) for valuable assistance.
Angew Chem Int Ed Engl
; 40(21): 4055-4060, 2001 Nov 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-12404491
17.
3-Substituted gem-cyclohexane sulfone based gamma-secretase inhibitors for Alzheimer's disease: conformational analysis and biological activity.
Bioorg Med Chem Lett
; 16(14): 3839-42, 2006 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16682202
18.
The stereocontrolled total synthesis of altohyrtin A/spongistatin 1: the CD-spiroacetal segment.
Org Biomol Chem
; 3(13): 2410-9, 2005 Jul 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-15976858
19.
Synthesis and conformational dynamics of tricyclic pyridones containing a fused seven-membered ring.
J Org Chem
; 67(26): 9354-60, 2002 Dec 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-12492338
20.
Tricyclic pyridones as functionally selective human GABAA alpha 2/3 receptor-ion channel ligands.
Bioorg Med Chem Lett
; 14(7): 1679-82, 2004 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-15026049