Detalhe da pesquisa
1.
Pharmacologic Characterization of LTGO-33, a Selective Small Molecule Inhibitor of the Voltage-Gated Sodium Channel NaV1.8 with a Unique Mechanism of Action.
Mol Pharmacol
; 105(3): 233-249, 2024 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38195157
2.
Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain.
Nature
; 534(7608): 494-9, 2016 06 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-27281198
3.
TMEM16A controls EGF-induced calcium signaling implicated in pancreatic cancer prognosis.
Proc Natl Acad Sci U S A
; 116(26): 13026-13035, 2019 06 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-31182586
4.
Using voltage-sensor toxins and their molecular targets to investigate NaV 1.8 gating.
J Physiol
; 596(10): 1863-1872, 2018 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29193176
5.
Crystallographic insights into sodium-channel modulation by the ß4 subunit.
Proc Natl Acad Sci U S A
; 110(51): E5016-24, 2013 Dec 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-24297919
6.
Microhemorrhage is an early event in the pulmonary fibrotic disease of PECAM-1 deficient FVB/n mice.
Exp Mol Pathol
; 97(1): 128-36, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24972347
7.
Animal toxins influence voltage-gated sodium channel function.
Handb Exp Pharmacol
; 221: 203-29, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24737238
8.
Mutational analysis of ProTx-I and the novel venom peptide Pe1b provide insight into residues responsible for selective inhibition of the analgesic drug target NaV1.7.
Biochem Pharmacol
; 181: 114080, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32511987
9.
Non-invasive diagnosis of early pulmonary disease in PECAM-deficient mice using infrared pulse oximetry.
Exp Mol Pathol
; 87(2): 152-8, 2009 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-19646434
10.
The Sixth Transmembrane Segment Is a Major Gating Component of the TMEM16A Calcium-Activated Chloride Channel.
Neuron
; 97(5): 1063-1077.e4, 2018 03 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29478917
11.
NaV1.1 inhibition can reduce visceral hypersensitivity.
JCI Insight
; 3(11)2018 06 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29875317
12.
Differential effect of Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1) on leukocyte infiltration during contact hypersensitivity responses.
PeerJ
; 5: e3555, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28713655
13.
The tarantula toxin ß/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity.
Sci Rep
; 7(1): 974, 2017 04 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-28428547
14.
Binary architecture of the Nav1.2-ß2 signaling complex.
Elife
; 52016 Feb 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-26894959
15.
Molecular basis of the remarkable species selectivity of an insecticidal sodium channel toxin from the African spider Augacephalus ezendami.
Sci Rep
; 6: 29538, 2016 07 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27383378
16.
Isolation of two insecticidal toxins from venom of the Australian theraphosid spider Coremiocnemis tropix.
Toxicon
; 123: 62-70, 2016 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27793656
17.
Nav1.1 modulation by a novel triazole compound attenuates epileptic seizures in rodents.
ACS Chem Biol
; 9(5): 1204-12, 2014 May 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-24635129
18.
Fluorescence spectroscopy of Rhodamine 6G: concentration and solvent effects.
Spectrochim Acta A Mol Biomol Spectrosc
; 121: 147-51, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24239710
19.
A distinct sodium channel voltage-sensor locus determines insect selectivity of the spider toxin Dc1a.
Nat Commun
; 5: 4350, 2014 Jul 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-25014760
20.
Animal toxins can alter the function of Nav1.8 and Nav1.9.
Toxins (Basel)
; 4(8): 620-32, 2012 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-23012651