Detalhe da pesquisa
1.
Discovery of pyrazolo[3,4-d]pyrimidines as novel mitogen-activated protein kinase kinase 3 (MKK3) inhibitors.
Bioorg Med Chem
; 98: 117561, 2024 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38157838
2.
Discovery of novel benzothiophene derivatives as potent and narrow spectrum inhibitors of DYRK1A and DYRK1B.
Bioorg Med Chem Lett
; 68: 128764, 2022 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35504513
3.
1,2,6-Thiadiazinones as Novel Narrow Spectrum Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CaMKK2) Inhibitors.
Molecules
; 23(5)2018 May 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-29783765
4.
Orphan Nuclear Receptor NR4A1 Binds a Novel Protein Interaction Site on Anti-apoptotic B Cell Lymphoma Gene 2 Family Proteins.
J Biol Chem
; 291(27): 14072-14084, 2016 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27129202
5.
Imidazo[1,2-b]pyridazines as inhibitors of DYRK kinases.
Eur J Med Chem
; 269: 116292, 2024 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-38479168
6.
Discovery and Characterization of Selective and Ligand-Efficient DYRK Inhibitors.
J Med Chem
; 64(15): 11709-11728, 2021 08 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34342227
7.
Binding and structural analyses of potent inhibitors of the human Ca2+/calmodulin dependent protein kinase kinase 2 (CAMKK2) identified from a collection of commercially-available kinase inhibitors.
Sci Rep
; 9(1): 16452, 2019 11 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31712618
8.
SGC-GAK-1: A Chemical Probe for Cyclin G Associated Kinase (GAK).
J Med Chem
; 62(5): 2830-2836, 2019 03 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30768268
9.
WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop.
Cell Rep
; 26(1): 79-93.e8, 2019 01 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30605688
10.
Validation of the protein kinase PfCLK3 as a multistage cross-species malarial drug target.
Science
; 365(6456)2019 08 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-31467193
11.
A TR3/Nur77 peptide-based high-throughput fluorescence polarization screen for small molecule Bcl-B inhibitors.
J Biomol Screen
; 13(7): 665-73, 2008 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-18626112
12.
Structural Analysis of Inhibitor Binding to CAMKK1 Identifies Features Necessary for Design of Specific Inhibitors.
Sci Rep
; 8(1): 14800, 2018 10 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30287839
13.
Identification and Optimization of 4-Anilinoquinolines as Inhibitors of Cyclinâ G Associated Kinase.
ChemMedChem
; 13(1): 48-66, 2018 01 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29072804
14.
Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations.
Sci Rep
; 7(1): 7501, 2017 08 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28790404
15.
TR-FRET-based high-throughput screening assay for identification of UBC13 inhibitors.
J Biomol Screen
; 17(2): 163-76, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22034497
16.
Structure of the thiazole biosynthetic enzyme THI1 from Arabidopsis thaliana.
J Biol Chem
; 281(41): 30957-66, 2006 Oct 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-16912043