Detalhe da pesquisa
1.
Evaluation of cytosine base editing and adenine base editing as a potential treatment for alpha-1 antitrypsin deficiency.
Mol Ther
; 30(4): 1396-1406, 2022 04 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35121111
2.
Adenine base editing reduces misfolded protein accumulation and toxicity in alpha-1 antitrypsin deficient patient iPSC-hepatocytes.
Mol Ther
; 29(11): 3219-3229, 2021 11 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34217893
3.
Left ventricular diastolic dysfunction in nonhuman primate model of dysmetabolism and diabetes.
BMC Cardiovasc Disord
; 15: 141, 2015 Oct 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-26518730
4.
Cytosine base editing inhibits hepatitis B virus replication and reduces HBsAg expression in vitro and in vivo.
Mol Ther Nucleic Acids
; 35(1): 102112, 2024 Mar 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38292874
5.
Gene Editing Technologies to Target HBV cccDNA.
Viruses
; 14(12)2022 11 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36560658
6.
Functionalized lipid-like nanoparticles for in vivo mRNA delivery and base editing.
Sci Adv
; 6(34)2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32937374
7.
Biocompatible, Purified VEGF-A mRNA Improves Cardiac Function after Intracardiac Injection 1 Week Post-myocardial Infarction in Swine.
Mol Ther Methods Clin Dev
; 9: 330-346, 2018 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30038937
8.
Halofenate is a selective peroxisome proliferator-activated receptor gamma modulator with antidiabetic activity.
Diabetes
; 55(9): 2523-33, 2006 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-16936200
9.
Peroxisome proliferator-activated receptors as attractive antiobesity targets.
Drug News Perspect
; 17(10): 661-9, 2004 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-15696231
10.
Quantification of ß-cell insulin secretory function using a graded glucose infusion with C-peptide deconvolution in dysmetabolic, and diabetic cynomolgus monkeys.
Diabetol Metab Syndr
; 5(1): 40, 2013 Jul 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-23886319
11.
Comparative plasma lipidome between human and cynomolgus monkey: are plasma polar lipids good biomarkers for diabetic monkeys?
PLoS One
; 6(5): e19731, 2011 May 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-21573191
12.
MBX-102/JNJ39659100, a novel non-TZD selective partial PPAR-γ agonist lowers triglyceride independently of PPAR-α activation.
PPAR Res
; 2009: 706852, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-19404482
13.
MBX-102/JNJ39659100, a novel peroxisome proliferator-activated receptor-ligand with weak transactivation activity retains antidiabetic properties in the absence of weight gain and edema.
Mol Endocrinol
; 23(7): 975-88, 2009 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-19389808
14.
Cross-Species Differential Plasma Protein Binding of MBX-102/JNJ39659100: A Novel PPAR-gamma Agonist.
PPAR Res
; 2008: 465715, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-18815616
15.
Selective Modulators of PPAR-gamma Activity: Molecular Aspects Related to Obesity and Side-Effects.
PPAR Res
; 2007: 32696, 2007.
Artigo
em Inglês
| MEDLINE | ID: mdl-17389769
16.
Isocaloric maternal low-protein diet alters IGF-I, IGFBPs, and hepatocyte proliferation in the fetal rat.
Am J Physiol Endocrinol Metab
; 285(5): E991-E1000, 2003 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-12902319
17.
Effects of inhibiting transcription and protein synthesis on basal and insulin-stimulated leptin gene expression and leptin secretion in cultured rat adipocytes.
Biochem Biophys Res Commun
; 307(4): 907-14, 2003 Aug 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-12878197
18.
Diet-induced obesity and hepatic gene expression alterations in C57BL/6J and ICAM-1-deficient mice.
Am J Physiol Endocrinol Metab
; 282(3): E703-13, 2002 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-11832376
19.
Overexpression of repressive cAMP response element modulators in high glucose and fatty acid-treated rat islets. A common mechanism for glucose toxicity and lipotoxicity?
J Biol Chem
; 278(51): 51316-23, 2003 Dec 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-14534319
20.
Peroxisome Proliferator-Activated Receptor delta: A Target with a Broad Therapeutic Potential for Drug Discovery.
PPAR Res
; 2008: 736362, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-19360114