Detalhe da pesquisa
1.
Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism.
Proc Natl Acad Sci U S A
; 121(9): e2313192121, 2024 Feb 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-38386706
2.
A Conserved Local Structural Motif Controls the Kinetics of PTP1B Catalysis.
J Chem Inf Model
; 63(13): 4115-4124, 2023 07 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37378552
3.
Discovery and Validation of the Binding Poses of Allosteric Fragment Hits to Protein Tyrosine Phosphatase 1b: From Molecular Dynamics Simulations to X-ray Crystallography.
J Chem Inf Model
; 63(9): 2644-2650, 2023 05 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37086179
4.
Resolving conformational changes that mediate a two-step catalytic mechanism in a model enzyme.
bioRxiv
; 2023 Jun 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-37398233
5.
Identification of GDC-1971 (RLY-1971), a SHP2 Inhibitor Designed for the Treatment of Solid Tumors.
J Med Chem
; 66(19): 13384-13399, 2023 Oct 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37774359
6.
A unifying Bayesian framework for merging X-ray diffraction data.
Nat Commun
; 13(1): 7764, 2022 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36522310
7.
Native SAD phasing at room temperature.
Acta Crystallogr D Struct Biol
; 78(Pt 8): 986-996, 2022 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35916223
8.
reciprocalspaceship: a Python library for crystallographic data analysis.
J Appl Crystallogr
; 54(Pt 5): 1521-1529, 2021 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34671231
9.
De Novo Proteins with Life-Sustaining Functions Are Structurally Dynamic.
J Mol Biol
; 428(2 Pt A): 399-411, 2016 Jan 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-26707197