Detalhe da pesquisa
1.
The Axl kinase domain in complex with a macrocyclic inhibitor offers first structural insights into an active TAM receptor kinase.
J Biol Chem
; 292(38): 15705-15716, 2017 09 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-28724631
2.
Structure-Based Drug Design and Synthesis of PI3Kα-Selective Inhibitor (PF-06843195).
J Med Chem
; 64(1): 644-661, 2021 01 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-33356246
3.
Lessons from (S)-6-(1-(6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)ethyl)quinoline (PF-04254644), an inhibitor of receptor tyrosine kinase c-Met with high protein kinase selectivity but broad phosphodiesterase family inhibition leading to myocardial degeneration in rats.
J Med Chem
; 56(17): 6651-65, 2013 Sep 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-23944843
4.
Homodimerization of the PAS-B domains of hypoxia-inducible factors.
J Phys Chem B
; 116(23): 6960-5, 2012 Jun 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-22424208
5.
Discovery of a novel class of exquisitely selective mesenchymal-epithelial transition factor (c-MET) protein kinase inhibitors and identification of the clinical candidate 2-(4-(1-(quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethanol (PF-04217903) for the treatment of cancer.
J Med Chem
; 55(18): 8091-109, 2012 Sep 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-22924734
6.
Structure based drug design of crizotinib (PF-02341066), a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK).
J Med Chem
; 54(18): 6342-63, 2011 Sep 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-21812414
7.
Structure of the catalytic domain of human protein kinase C beta II complexed with a bisindolylmaleimide inhibitor.
Biochemistry
; 45(47): 13970-81, 2006 Nov 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-17115692
8.
Ligands of the Mn2+ bound to porcine mitochondrial NADP-dependent isocitrate dehydrogenase, as assessed by mutagenesis.
Biochemistry
; 43(10): 2821-8, 2004 Mar 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-15005617
9.
Crystal structure of porcine mitochondrial NADP+-dependent isocitrate dehydrogenase complexed with Mn2+ and isocitrate. Insights into the enzyme mechanism.
J Biol Chem
; 277(45): 43454-62, 2002 Nov 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-12207025