RESUMO
BACKGROUND: Clinical and pathologic criteria to distinguish drug-induced subacute lupus erythematosus (DI-SCLE) from idiopathic (I-SCLE) are controversial. OBJECTIVE: The aim of the survey was a retrospective analysis of a consistent number of iatrogenous and idiopathic SCLE cases, by means of clinical and histopathologic investigation. METHODS: Eleven European university dermatology units collected all diagnosed cases from January 2000 to December 2016. Board-certified dermatopathologists reviewed the histopathologic specimens. Statistical analysis included Student t test, exact test of goodness-of-fit, Fisher's exact test, and the Cochran-Mantel-Haenszel test for repeated measures. RESULTS: Out of 232 patients, 67 (29%) belonged to the DI-SCLE group. Patients with DI-SCLE were significantly older and reported more systemic symptoms than those with I-SCLE. No statistical differences were found for presentation pattern or serology, while histopathology showed a significant association of mucin deposition (P = .000083), direct immunofluorescence positivity for granular immunoglobulin M, and C3 deposits on the basement membrane zone (P = .0041) for I-SCLE and of leukocytoclastic vasculitis (P = .0018) for DI-SCLE. LIMITATIONS: This is a retrospective study. CONCLUSION: An integrated clinical and immunopathologic evaluation is useful to differentiate I-SCLE from DI-SCLE. Older age at onset and more frequent systemic symptoms characterize DI-SCLE. Mucin deposition and immunofluorescence findings are found in I-SCLE, and leukocytoclastic vasculitis is found in DI-SCLE.
Assuntos
Toxidermias/metabolismo , Toxidermias/patologia , Lúpus Eritematoso Cutâneo/metabolismo , Lúpus Eritematoso Cutâneo/patologia , Adulto , Fatores Etários , Anticorpos Antinucleares/sangue , Membrana Basal/metabolismo , Complemento C3/metabolismo , Toxidermias/etiologia , Europa (Continente) , Feminino , Humanos , Imunoglobulina M/metabolismo , Lúpus Eritematoso Cutâneo/etiologia , Masculino , Pessoa de Meia-Idade , Mucinas/metabolismo , Estudos Retrospectivos , Vasculite Leucocitoclástica Cutânea/etiologiaAssuntos
Alopecia/diagnóstico por imagem , Cabelo/diagnóstico por imagem , Isquemia/diagnóstico por imagem , Pressão/efeitos adversos , Couro Cabeludo/irrigação sanguínea , Adolescente , Adulto , Idoso , Alopecia/etiologia , Criança , Pré-Escolar , Dermoscopia , Feminino , Humanos , Lactente , Recém-Nascido , Isquemia/etiologia , Pessoa de Meia-Idade , Couro Cabeludo/diagnóstico por imagem , Adulto JovemAssuntos
Histiocitose de Células de Langerhans/patologia , Dermatopatias/patologia , Dermatite Seborreica/etiologia , Diabetes Insípido/complicações , Histiocitose de Células de Langerhans/complicações , Histiocitose de Células de Langerhans/diagnóstico , Humanos , Hipopituitarismo/complicações , Masculino , Pessoa de Meia-Idade , Dermatopatias/complicações , Dermatopatias/diagnósticoRESUMO
A 69-year-old woman with invasive ductal breast cancer (BC) presented multiple asymptomatic alopecic areas of the scalp. Trichoscopy revealed peripheral black dots (BDs) and an atypical vascular pattern. Histopathology confirmed the diagnosis of BC metastases. Cutaneous and scalp metastases are a possible sign of advanced and widespread BC, and the diagnosis may be challenging. The trichoscopy of scalp metastases has never been described. BDs and an atypical vascular pattern in our case were a diagnostic clue.