[Relationship between episodic memory and resting-state brain functional connectivity network in patients with Alzheimer's disease and mild cognition impairment].

OBJECTIVE: To explore the relationship between the scores of episodic memory (EM) encoding and retrieving and the resting-state changes of brain functional connectivity (FC) network of Alzheimer's disease (AD) and mild cognition impairment (MCI) patients. METHODS: All subjects were recruited from special care clinic and ward and health physical examination center, Qingdao Huanxiu Community and Affiliated Hospital, Medical College of Qingdao university from January 2009 to July 2012.They were divided into AD group (n = 16), MCI group (n = 24) and normal control (NC) group (n = 24). The resting-state fMRI scans were performed with GE3.0T to acquire the blood oxygenation level dependent signals for EM encoding and retrieving. The two-sample t test was conducted between the groups and linear correlation analysis performed between EM and FC. RESULTS: Compared to the NC group, the AD and MCI groups exhibited decreased FC to posterior cingulated cortex (PCC) mainly in bilateral lateral temporal lobe, medial prefrontal cortex and right insula.Increased regions existed in posterior cerebellar lobe. Compared with the MCI group, the AD group showed decreased FC to PCC in medial prefrontal cortex, bilateral insulas, right inferior temporal gyrus and right fusiform gyrus.And increased regions lied in posterior cerebellar lobe, right occipital lobe and left superior parietal lobule. Compared with the NC group, the MCI group exhibited decreased FC to PCC in left lingualis gyrus, left frontal lobe, right middle temporal gyrus and corpus callosum.And increased regions lied in posterior cerebellar lobe.EM encoding scores (%) (AD group 34 ± 20, MCI group 47 ± 17, NC group 69 ± 15) were significantly different among three groups (P < 0.05).And retrieving scores (%) (AD group 31 ± 18, MCI group 57 ± 22, NC group 81 ± 16) were significantly different among three groups (P < 0.05). Altered functional connectivity regions of left triangle orbital-inferior frontal gyrus (r = 0.642 98), left cuneus (r = 0.642 98) and left caudate nucleus (r = 0.642 68) showed positive correlations with the EM encoding scores in AD group (all P < 0.005). Other groups were not statistically significant. CONCLUSION: The resting-state FC networks of AD and MCI groups show significant differences. The MCI and AD patients have progressively decreased scores of episodic memory encoding and retrieving.And the declines of episodic memory encoding and partial regions of resting-state FC network are positively correlated in the AD group.

[Observation of the cognition and the velocities of blood in the brain in cerebral arteriosclerosis and infarct patients].

OBJECTIVE: To observe the change of the cognition and the supply of blood in brain in healthy people and patients with arteriosclerosis (AS) and cerebral infarct. METHOD: 1) control group: healthy people, 30 cases. 2) AS group: 22 cases with cerebral arteriosclerosis. Cerebrovascular infarct patients were divided into two groups. 3) 2W group: 21 cases, the patients' course of disease was shorter than two weeks. 4) 6M group: 20 cases, the patients' course of disease was from six months to four years. All cases were checked with cognitive P300 and transcranial doppler ultrasound (TCD) and mini-mental status examination (MMSE). RESULT: The result revealed that the P300 incubation period in 2W group, 6M group and the AS group was remarkable extend than the control group (P<0.01), meanwhile the period of the 6M group was longer than the AS group (P<0.05); the amplitude of the wave of the 2W group and 6M group were shorter than the control group (P<0.05; 0.05). The velocities of bilateral MCA and right ACA were remarkable improved in AS group (P<0.05; 0.01), and the velocities of left MCA both in 2W and 6M group, the right ACA and BA in 6M group were remarkably decreased than the control group (P<0.05; 0.01). The grades of MMSE in all patients were lower than the control group and the grades in 6M group was lower than the AS group. CONCLUSION: There are some changes in the P300 and abnormality of brain blood supply in the cerebral infarct patients and AS patients. The longer the course, the more serious of the cognition with the patients.