Detalhe da pesquisa
1.
Inducing Ito,f and phase 1 repolarization of the cardiac action potential with a Kv4.3/KChIP2.1 bicistronic transgene.
J Mol Cell Cardiol
; 164: 29-41, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34823101
2.
Genetic variants in TRPM7 associated with unexplained stillbirth modify ion channel function.
Hum Mol Genet
; 29(11): 1797-1807, 2020 07 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-31423533
3.
Identification through action potential clamp of proarrhythmic consequences of the short QT syndrome T618I hERG 'hotspot' mutation.
Biochem Biophys Res Commun
; 596: 49-55, 2022 03 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35114584
4.
Inhibition of the hERG potassium channel by phenanthrene: a polycyclic aromatic hydrocarbon pollutant.
Cell Mol Life Sci
; 78(23): 7899-7914, 2021 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-34727194
5.
Serine mutation of a conserved threonine in the hERG K+ channel S6-pore region leads to loss-of-function through trafficking impairment.
Biochem Biophys Res Commun
; 526(4): 1085-1091, 2020 06 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32321643
6.
CRISPR/Cas9 editing in human pluripotent stem cell-cardiomyocytes highlights arrhythmias, hypocontractility, and energy depletion as potential therapeutic targets for hypertrophic cardiomyopathy.
Eur Heart J
; 39(43): 3879-3892, 2018 11 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-29741611
7.
Molecular mechanisms of congenital hyperinsulinism due to autosomal dominant mutations in ABCC8.
Hum Mol Genet
; 24(18): 5142-53, 2015 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26092864
8.
The impact of recent advances in genetics in understanding disease mechanisms underlying the long QT syndromes.
Biol Chem
; 397(7): 679-93, 2016 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26910742
9.
Cellular mechanisms underlying the increased disease severity seen for patients with long QT syndrome caused by compound mutations in KCNQ1.
Biochem J
; 462(1): 133-42, 2014 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24912595
10.
In situ monolayer patch clamp of acutely stimulated human iPSC-derived cardiomyocytes promotes consistent electrophysiological responses to SK channel inhibition.
Sci Rep
; 14(1): 3185, 2024 02 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-38326449
11.
A basic residue in the proximal C-terminus is necessary for efficient activation of the M-channel subunit Kv7.2 by PI(4,5)P2.
Pflugers Arch
; 465(7): 945-53, 2013 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-23291709
12.
Readthrough of long-QT syndrome type 1 nonsense mutations rescues function but alters the biophysical properties of the channel.
Biochem J
; 443(3): 635-42, 2012 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22309168
13.
New synthetic cannabinoids and the potential for cardiac arrhythmia risk.
J Mol Cell Cardiol Plus
; 6: 100049, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-38143960
14.
Evaluating pro-arrhythmogenic effects of the T634S-hERG mutation: insights from a simulation study.
Interface Focus
; 13(6): 20230035, 2023 Dec 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-38106919
15.
Retinoic acid signaling modulation guides in vitro specification of human heart field-specific progenitor pools.
Nat Commun
; 14(1): 1722, 2023 04 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-37012244
16.
Characterization of a binding site for anionic phospholipids on KCNQ1.
J Biol Chem
; 286(3): 2088-100, 2011 Jan 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-21084310
17.
Evolutionary coupling analysis guides identification of mistrafficking-sensitive variants in cardiac K+ channels: Validation with hERG.
Front Pharmacol
; 13: 1010119, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36339618
18.
Direct observation of individual KCNQ1 potassium channels reveals their distinctive diffusive behavior.
J Biol Chem
; 285(6): 3664-3675, 2010 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-19940153
19.
Mechanisms of disease pathogenesis in long QT syndrome type 5.
Am J Physiol Cell Physiol
; 298(2): C263-73, 2010 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-19907016
20.
COVID-19 Management and Arrhythmia: Risks and Challenges for Clinicians Treating Patients Affected by SARS-CoV-2.
Front Cardiovasc Med
; 7: 85, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32432127