Detalhe da pesquisa
1.
Base excision repair of the N-(2-deoxy-d-erythro-pentofuranosyl)-urea lesion by the hNEIL1 glycosylase.
Nucleic Acids Res
; 51(8): 3754-3769, 2023 05 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37014002
2.
Cryo neutron crystallography demonstrates influence of RNA 2'-OH orientation on conformation, sugar pucker and water structure.
Nucleic Acids Res
; 50(13): 7721-7738, 2022 07 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-35819202
3.
Shorter Is Better: The α-(l)-Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAs.
J Am Chem Soc
; 145(36): 19691-19706, 2023 09 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-37638886
4.
Water structure around a left-handed Z-DNA fragment analyzed by cryo neutron crystallography.
Nucleic Acids Res
; 49(8): 4782-4792, 2021 05 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33872377
5.
Overcoming GNA/RNA base-pairing limitations using isonucleotides improves the pharmacodynamic activity of ESC+ GalNAc-siRNAs.
Nucleic Acids Res
; 49(19): 10851-10867, 2021 11 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34648028
6.
Computational redesign of a fluorogen activating protein with Rosetta.
PLoS Comput Biol
; 17(11): e1009555, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34748541
7.
Synthesis and characterization of chiral 6-azaspiro[2.5]octanes as potent and selective antagonists of the M4 muscarinic acetylcholine receptor.
Bioorg Med Chem Lett
; 56: 128479, 2022 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34838649
8.
Incorporating a Thiophosphate Modification into a Common RNA Tetraloop Motif Causes an Unanticipated Stability Boost.
Biochemistry
; 59(49): 4627-4637, 2020 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33275419
9.
Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity.
Nucleic Acids Res
; 46(16): 8090-8104, 2018 09 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-30107495
10.
Roles of Residues Arg-61 and Gln-38 of Human DNA Polymerase η in Bypass of Deoxyguanosine and 7,8-Dihydro-8-oxo-2'-deoxyguanosine.
J Biol Chem
; 290(26): 15921-33, 2015 Jun 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-25947374
11.
Discovery, characterization and biological evaluation of a novel (R)-4,4-difluoropiperidine scaffold as dopamine receptor 4 (D4R) antagonists.
Bioorg Med Chem Lett
; 26(23): 5757-5764, 2016 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28327307
12.
Total synthesis of stemaphylline N-oxide and related C9a-epimeric analogues.
Chemistry
; 19(36): 11847-52, 2013 Sep 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-23956045
13.
Synthesis and Biophysical Properties of Phosphorodiamidate Piperidino Oligomers.
Org Lett
; 25(6): 901-906, 2023 02 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-36734846
14.
RNAs Containing Carbocyclic Ribonucleotides.
Org Lett
; 24(2): 525-530, 2022 01 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-34958225
15.
Structure and function of YghU, a nu-class glutathione transferase related to YfcG from Escherichia coli.
Biochemistry
; 50(7): 1274-81, 2011 Feb 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-21222452
16.
Molecular basis for cyclooxygenase inhibition by the non-steroidal anti-inflammatory drug naproxen.
J Biol Chem
; 285(45): 34950-9, 2010 Nov 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-20810665
17.
Crystal structures of Trypanosoma brucei sterol 14alpha-demethylase and implications for selective treatment of human infections.
J Biol Chem
; 285(3): 1773-80, 2010 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19923211
18.
Analysis of the structure and function of YfcG from Escherichia coli reveals an efficient and unique disulfide bond reductase.
Biochemistry
; 48(28): 6559-61, 2009 Jul 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-19537707
19.
Cryo-neutron crystallographic data collection and preliminary refinement of left-handed Z-DNA d(CGCGCG).
Acta Crystallogr F Struct Biol Commun
; 74(Pt 10): 603-609, 2018 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30279310
20.
A Novel M1 PAM VU0486846 Exerts Efficacy in Cognition Models without Displaying Agonist Activity or Cholinergic Toxicity.
ACS Chem Neurosci
; 9(9): 2274-2285, 2018 09 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-29701957