Detalhe da pesquisa
1.
NRF2 activates growth factor genes and downstream AKT signaling to induce mouse and human hepatomegaly.
J Hepatol
; 72(6): 1182-1195, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32105670
2.
Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers.
Nature
; 501(7466): 232-6, 2013 Sep 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-23934108
3.
Role of the E3 ubiquitin ligase RNF157 as a novel downstream effector linking PI3K and MAPK signaling pathways to the cell cycle.
J Biol Chem
; 292(35): 14311-14324, 2017 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28655764
4.
Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition.
Nat Chem Biol
; 12(10): 779-86, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27479743
5.
Glutamine metabolism via glutaminase 1 in autosomal-dominant polycystic kidney disease.
Nephrol Dial Transplant
; 33(8): 1343-1353, 2018 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29420817
6.
Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors.
Proc Natl Acad Sci U S A
; 112(32): E4410-7, 2015 Aug 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-26216984
7.
Regulatory T Cell Modulation by CBP/EP300 Bromodomain Inhibition.
J Biol Chem
; 291(25): 13014-27, 2016 Jun 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-27056325
8.
Hominoid-specific enzyme GLUD2 promotes growth of IDH1R132H glioma.
Proc Natl Acad Sci U S A
; 111(39): 14217-22, 2014 Sep 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-25225364
9.
Quantitative phosphoproteomic analysis of the PI3K-regulated signaling network.
Proteomics
; 16(14): 1992-7, 2016 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27282143
10.
Phosphoproteome analysis of the MAPK pathway reveals previously undetected feedback mechanisms.
Proteomics
; 16(14): 1998-2004, 2016 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27273156
11.
RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth.
Nature
; 464(7287): 431-5, 2010 Mar 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-20130576
12.
Glutamine metabolism via glutaminase 1 in autosomal-dominant polycystic kidney disease.
Nephrol Dial Transplant
; 35(10): 1824, 2020 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31329939
13.
The biology of cancer: metabolic reprogramming fuels cell growth and proliferation.
Cell Metab
; 7(1): 11-20, 2008 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-18177721
14.
ATP citrate lyase inhibition can suppress tumor cell growth.
Cancer Cell
; 8(4): 311-21, 2005 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-16226706
15.
PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation.
Proc Natl Acad Sci U S A
; 105(42): 16314-9, 2008 Oct 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-18852460
16.
NRF2 Activation Promotes Aggressive Lung Cancer and Associates with Poor Clinical Outcomes.
Clin Cancer Res
; 27(3): 877-888, 2021 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33077574
17.
Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis.
J Cell Biol
; 162(1): 59-69, 2003 Jul 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-12847083
18.
Aminoisoxazoles as Potent Inhibitors of Tryptophan 2,3-Dioxygenase 2 (TDO2).
ACS Med Chem Lett
; 9(5): 417-421, 2018 May 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29795752
19.
Pan-Cancer Metabolic Signature Predicts Co-Dependency on Glutaminase and De Novo Glutathione Synthesis Linked to a High-Mesenchymal Cell State.
Cell Metab
; 28(3): 383-399.e9, 2018 09 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30043751
20.
The Hippo pathway effector TAZ induces TEAD-dependent liver inflammation and tumors.
Sci Signal
; 11(547)2018 09 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30206136