Detalhe da pesquisa
1.
Synthesis, In Silico and Kinetics Evaluation of N-(ß-d-glucopyranosyl)-2-arylimidazole-4(5)-carboxamides and N-(ß-d-glucopyranosyl)-4(5)-arylimidazole-2-carboxamides as Glycogen Phosphorylase Inhibitors.
Int J Mol Sci
; 25(9)2024 Apr 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-38731811
2.
Design and Synthesis of 3-(ß-d-Glucopyranosyl)-4-amino/4-guanidino Pyrazole Derivatives and Analysis of Their Glycogen Phosphorylase Inhibitory Potential.
Molecules
; 28(7)2023 Mar 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-37049768
3.
2-Acetamido-2-deoxy-d-glucono-1,5-lactone Sulfonylhydrazones: Synthesis and Evaluation as Inhibitors of Human OGA and HexB Enzymes.
Int J Mol Sci
; 23(3)2022 Jan 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-35162960
4.
Aromatic Stacking Facilitated Self-Assembly of Ultrashort Ionic Complementary Peptide Sequence: ß-Sheet Nanofibers with Remarkable Gelation and Interfacial Properties.
Biomacromolecules
; 21(7): 2670-2680, 2020 07 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-32401499
5.
Synthetic flavonoid derivatives targeting the glycogen phosphorylase inhibitor site: QM/MM-PBSA motivated synthesis of substituted 5,7-dihydroxyflavones, crystallography, in vitro kinetics and ex-vivo cellular experiments reveal novel potent inhibitors.
Bioorg Chem
; 102: 104003, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32771768
6.
Potential Dissociative Glucocorticoid Receptor Activity for Protopanaxadiol and Protopanaxatriol.
Int J Mol Sci
; 20(1)2018 Dec 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-30591629
7.
Structure based inhibitor design targeting glycogen phosphorylase B. Virtual screening, synthesis, biochemical and biological assessment of novel N-acyl-ß-d-glucopyranosylamines.
Bioorg Med Chem
; 22(17): 4810-25, 2014 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25092521
8.
Discovery of Potent Multikinase Type-II Inhibitors Targeting CDK5 in the DFG-out Inactive State with Promising Potential against Glioblastoma.
J Med Chem
; 2024 Apr 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-38686637
9.
Synthesis, enzyme kinetics and computational evaluation of N-(ß-D-glucopyranosyl) oxadiazolecarboxamides as glycogen phosphorylase inhibitors.
Bioorg Med Chem
; 21(18): 5738-47, 2013 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23938052
10.
In Silico-Motivated Discovery of Novel Potent Glycogen Synthase-3 Inhibitors: 1-(Alkyl/arylamino)-3H-naphtho[1,2,3-de]quinoline-2,7-dione Identified as a Scaffold for Kinase Inhibitor Development.
Pharmaceuticals (Basel)
; 16(5)2023 Apr 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-37242443
11.
Multidisciplinary docking, kinetics and X-ray crystallography studies of baicalein acting as a glycogen phosphorylase inhibitor and determination of its' potential against glioblastoma in cellular models.
Chem Biol Interact
; 382: 110568, 2023 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37277066
12.
hCINAP is an atypical mammalian nuclear adenylate kinase with an ATPase motif: structural and functional studies.
Proteins
; 80(1): 206-20, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-22038794
13.
Kinetics, in silico docking, molecular dynamics, and MM-GBSA binding studies on prototype indirubins, KT5720, and staurosporine as phosphorylase kinase ATP-binding site inhibitors: the role of water molecules examined.
Proteins
; 79(3): 703-19, 2011 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-21287607
14.
Evaluation of acrylamide-based molecularly imprinted polymer thin-sheets for specific protein capture-a myoglobin model.
Biomed Phys Eng Express
; 7(4)2021 06 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-34107465
15.
Structure-Based Design of Potent Selective Nanomolar Type-II Inhibitors of Glycogen Synthase Kinase-3ß.
J Med Chem
; 64(3): 1497-1509, 2021 02 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33499592
16.
Nanomolar inhibition of human OGA by 2-acetamido-2-deoxy-d-glucono-1,5-lactone semicarbazone derivatives.
Eur J Med Chem
; 223: 113649, 2021 Nov 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34186233
17.
1-(3-Deoxy-3-fluoro-beta-d-glucopyranosyl) pyrimidine derivatives as inhibitors of glycogen phosphorylase b: Kinetic, crystallographic and modelling studies.
Bioorg Med Chem
; 18(10): 3413-25, 2010 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20430629
18.
Glucose-based spiro-isoxazolines: a new family of potent glycogen phosphorylase inhibitors.
Bioorg Med Chem
; 17(20): 7368-80, 2009 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19781947
19.
Toward Rational Design of Selective Molecularly Imprinted Polymers (MIPs) for Proteins: Computational and Experimental Studies of Acrylamide Based Polymers for Myoglobin.
J Phys Chem B
; 123(26): 5432-5443, 2019 07 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31150581
20.
Identification of C-ß-d-Glucopyranosyl Azole-Type Inhibitors of Glycogen Phosphorylase That Reduce Glycogenolysis in Hepatocytes: In Silico Design, Synthesis, in Vitro Kinetics, and ex Vivo Studies.
ACS Chem Biol
; 14(7): 1460-1470, 2019 07 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-31243960